Hepatic steatosis - DPP IV

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Effect of DPP IV inhibitors on Hepatic steatosis in HepG2 cell line HepG2 cells express high levels of DPP IV activity DP-IV -/- Mice are Resistant to HFD-Induced Hepatic Lipid Accumulation. SREBP-1c is a master gene that regulates the expression of lipogenic genes, and increased expression of SREBP-1c is associated with fatty livers in murine models of diabetes. HFD-fed DP-IV -/- mice PPAR  expression was up-regulated whereas SREBP-1c expression was down-regulated in the liver.

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