Neonatal Ventilation

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Basics of Neonatal Ventilation : 

Dr Sam Sen Specialist Registrar Paediatrics The Royal Oldham Hospital Basics of Neonatal Ventilation

Learning Objectives : 

Learning Objectives Learn about basic Neonatal Anatomy & Physiology in relation to ventilation Learn different modes of mechanical ventilation of neonates

History of Ventilation : 

History of Ventilation Old Testament: –Exodus 1:15-17 -Story of the Hebrew midwife Puah who….“breathed into the baby’s mouth to cause the baby to cry” •Hippocrates ~ 400 BC Described intubation of the trachea to support breathing 1600s onwards Understanding of fundamental laws of gas pressure and volume (Robert Boyle & Robert Hooke) Vital gas –oxygen and its role in respiration –Antoine Lavoisier 1789 Air-pipe intra tracheal ventilation Bellows type ventilation with pressure limiting valves

Specific indications for ventilation : 

Specific indications for ventilation Respiratory distress syndrome (RDS , SDLD) - surfactant deficiency Meconium aspiration Congenital pneumonia Persistent pulmonary hypertension of the newborn (PPHN) Bronchopulmonary dysplasia (BPD) Apnoea Congenital diaphragmatic hernia(CDH)

Stages of lung development : 

Stages of lung development

Anatomic & Physiologic Attributes : 

Anatomic & Physiologic Attributes Prematurity - tissues, organs are not ready for extrauterine life Immature chemoreceptors - prone to apnoea Small, immature lungs Surfactant deficiency -undeveloped alveoli do not function in gas exchange /vulnerability to distention and oxidation injury

Anatomic & Physiologic Attributes : 

Anatomic & Physiologic Attributes Fragile airways - subject to damage from Intubation tracheal, nasogastric, orogastric tubes Suctioning Patient sucking on tubes

Anatomic & Physiologic Attributes : 

Anatomic & Physiologic Attributes Lung compliance is low and changes rapidly - volume monitoring is critical, regardless of target Thoracic compliance is high - minimal skeletal support for lungs Patients will grow - prolonged intubation ==> changing to larger tubes

Complications of ventilation : 

Complications of ventilation Bronchopulmonary dysplasia, due to: mmature, vulnerable lungs inflammation due to ventilator-induced lung injury (VILI) oxygen toxicity oxygen free radicals

Complications of ventilation : 

Complications of ventilation Extraneous air, due to hyperdistension Pulmonary interstitial emphysema Pneumothorax Pneumomediastinum Due to increased mean airway pressure Decreased cardiac output Decreased urinary output Increased intracranial pressure Intraventricular haemorrhage (IVH) Necrotizing Enterocolitis (NEC)

Ventilation Modes : 

Ventilation Modes

Noninvasive Ventilation : 

Noninvasive Ventilation Nasal Nasal continuous positive airway pressure (NCPAP) Nasal positive pressure ventilation (NPPV Synchronized nasal positive pressure ventilation (SNPPV) Synchronized nasal intermittent mandatory ventilation (SNIMV)

Noninvasive : 

Noninvasive Advantages less bronchopulmonary dysplasia less ventilator associated pneumonia Disadvantages limited control over ventilation damage to nasal tissue

Invasive Ventilation : 

Invasive Ventilation Intermittent mandatory ventilation (IMV) Synchronized intermittent mandatory ventilation (SIMV) Assist-control ventilation Pressure support ventilation (PSV)

Invasive Ventilation : 

Invasive Ventilation Advantage greater control over ventilation Disadvantages more bronchopulmonary dysplasia more ventilator associated pneumonia more airway complications from tubes

Ventilatory Modes : 

Ventilatory Modes Mandatory modes Mandatory level of ventilator support Spontaneous respiratory effort in excess of set rate unsupported IMV / CMV SIMV Assist modes Support according to set parameters for all spontaneous respiratory effort Minimum back-up rate in event of apnoea / reduced drive PTV / Assist control Pressure support

SIMV : 

SIMV Set rate determines mandatory breath rate All mandatory breaths fully supported according to set parameters (TCPLV or Volume controlled) Breaths in excess of mandatory rate are supported by bias flow only Weaning on simple SIMV may lead to fatigue due to increased work of breathing from unsupported breaths

Controls - typical settings : 

Controls - typical settings Rate 30 - 60/min PIP 18 - 25 (for TV 5-7 mL/kg) TV 5 - 7 mL / kg BW Insp. Flow 3 - 8 L/min Insp. Time 0.25 - 0.40 sec (for I < E) PEEP 3 - 5 cm H2O (for FIO2 < .6) FIO2 for PO2 = 50- 80 mm Hg; SPO2 = 85-93% Exp. flow trigger - adjust with graphics

Pressure support ventilation : 

Pressure support ventilation Pressure limited Set PIP above baseline PEEP Assist mode (i.e. patient triggered) Demand inspiratory flow Time limit Flow cycled Improves synchronisation with spontaneous respiratory effort

Any Questions : 

Any Questions