EVALUATION OF LIQUID DOSAGE FORMS

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EVALUATION OF LIQUID DOSAGE FORMS : 

EVALUATION OF LIQUID DOSAGE FORMS AJU S.SAM 1ST YR. M.PHARM NEHRU COLLEGE OF PHARMACY

Slide 2: 

Q.C OF SOLUTIONS Q.C OF SUSPENSIONS Q.C OF EMULSIONS

Q.C OF SOLUTIONS : 

Q.C OF SOLUTIONS COLOUR SPECTROPHOTOMETRY CLARITY LIGHT SCATTERING TASTE AND ODOUR FORMULATION CHEMIST / TASTE SENSITIVE INDIVIDUALS

CONT.. : 

CONT.. INTEGRITY OF SEAL

CONT.. : 

CONT.. VISCOSITY 1. OSTWALD VISCOMETER 2.CONE AND PLATE VISCOMETER

CONT.. : 

CONT.. VOLUME DRUG CONTENT

Q.C OF SUSPENSIONS : 

Q.C OF SUSPENSIONS SEDIMENTATION METHODS RHEOLOGIC METHODS ELECTROKINETIC METHODS MICROMERITIC METHODS

SEDIMENTATION METHODS : 

SEDIMENTATION METHODS SEDIMENTATION VOLUME = ULTIMATE HEIGHT OF SEDIMENT INITIAL HEIGHT OF SUSPENSION Hµ/H0 TIME

RHEOLOGICAL METHODS : 

RHEOLOGICAL METHODS BROOK FIELD VISCOMETER WITH T-SPINDLE dial reading no. of turn of spindle YV = gv (ρp - ρm ) A

ELECTROKINETIC METHODS : 

ELECTROKINETIC METHODS MEASUREMENT OF ZETA POTENTIAL BY ELECTROPHORETIC METHOD UE = 2 ε z f(κa) 3η where UE = electrophoretic mobility, z = zeta potential, ε = dielectric constant, η = viscosity f(κa) = Henry’s function.

MICROMERITIC METHODS : 

MICROMERITIC METHODS MICROSCOPIC MEASUREMENTS COULTER COUNTER APPARATUS

Q.C OF EMULSIONS : 

Q.C OF EMULSIONS STABILITY STUDIES TEMPERATURE 60-90 days at 45 or 500c 5-6 months at 370c 12-18 months at room temp.

Cont.. : 

Cont.. CENTRIFUGATION No serious deterioration at 2000 -3000 rpm at room temp. AGITATION Reciprocating shaker 60 cycles/min at room temp & at 450c for 24-48 hrs.

Cont.. : 

Cont.. PARAMETERS COMMONLY MEASURED PHASE SEPARATION – no visible sign of separation after 1 month storage at 40c - and 2 or 3 freeze-thaw cycle b/n -200c & +250c

Cont.. : 

Cont.. VISCOSITY CONE AND PLATE VISCOMETER

CONT.. : 

CONT.. PENETROMETER Ideally no change in 0.04 – 400 days viscosity elapsed time (days)

ELECTROPHORETIC PROPERTIES : 

ELECTROPHORETIC PROPERTIES O/W EMULSION – low resistance, if increased resistance oil drop aggregation is there. W/O EMULSION – do not conduct electricity

PARTICLE SIZE NUMBER ANALYSIS : 

PARTICLE SIZE NUMBER ANALYSIS MICROSCOPIC MEASUREMENT COULTER COUNTER

reference : 

reference LeonLachman,Herbert.A.Lieberman, Joseph.L.Kaing . The Theory and Practice of Industrial Pharmacy; 3rdedition,1991:457-533 www.pharmapedia.com/emulsion#Quality_control_test_for_emulsions www.pharmapedia.com/suspension#Quality_control_test_for_suspensions Martin Siewert, Jennifer Dressman, Cynthia K. Brown, and Vinod P. Shah.FIP/AAPS Guidelines to Dissolution/in Vitro Release Testing of Novel/Special Dosage Forms. January 27, 2003; Accepted: February 14, 2003

Slide 20: 

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