dissolution

Views:
 
Category: Entertainment
     
 

Presentation Description

No description available.

Comments

Presentation Transcript

PowerPoint Presentation:

1 JOURNAL CLUB PRESENTATION Presented by…. saiesh phaldesa

In- Vitro Evaluation of Commercial Brands and Government Hospital supplied Tablets of Paracetamol :

2 Authors Name : Dr. P. G. Yeole, P.Puranik, A.P.Sherje, and M.Y. Momin. Journal Name : Indian Journal of Pharmaceutical Education. Volume : 39(1) Jan-Mar. 2005 Page No. : 54-56. In- Vitro Evaluation of Commercial Brands and Government Hospital supplied Tablets of Paracetamol

ABSTRACT :

3 ABSTRACT Popular marketed brand of paracetamol tablet A,B and C and paracetamol obtained from two different Government hospitals and evaluated comparatively for six vitro parameters both official and non official viz. weight variation, friability, hardness, drug content, disintegration and dissolution. The result of study revealed that quality of hospital supplied paracetamol tablet is comparable to that of the popular marketed brand of paracetamol; irrespective of the general psychology of population that the quality of Government hospital supplied medicine is poor.

Introduction:

4 Introduction Paracetamol is a non-steroidal analgesic & antipyretic agent. The efficacy of pharmaceutical product depends on its formulation property & manufacturing method. It is general psychology that the quality of medicine supplied by Govt. hospital is poor as compared to marketed brand, so it was intended to carry out survey with people of different status. 30% 70%

Dissolution study:- :

5 Dissolution study:- Material: A,B,C three commercial brand & D & E hospital supply. Experimental condition: Medium – Phosphate buffer (P H = 7.8) Apparatus – Model DA3 paddle type Temp.: 37 ± 0.5 0 C Dissolution test:- 900ml Phosphate buffer (P H = 7.8) as a dissolution medium, paddle speed of 50 rpm for 30 min. Sample of 1ml were taken at each 10 min. interval, filtered & diluted suitably; It was replaced by same amt. of fresh medium each time. Absorbance of resulting solution was measured at about 249 nm against Phosphate buffer as a blank. The amt. of dissolved drug was calculated using standard calibration curve.

Rate of Dissolution (in-vitro) of different Paracetamol tablets :

6 Rate of Dissolution (in-vitro) of different Paracetamol tablets Sr. No Medium Time in Min. Cumulative % drug release A B C D E 1. Buffer (P H 7.8) 10 min. 75.00% 79.20% 70.20% 63.19% 65.38% 2. Buffer (P H 7.8) 20 min. 79.26% 85.98% 81.20% 75.03% 80.11% 3. Buffer (P H 7.8) 30 min. 96.87% 98.26% 100.06% 97.72% 99.04%

PowerPoint Presentation:

7 Comparative release profile for tablets A,B, C, D,&E , where A, B & C are marketed brands of Paracetamol tablet . D& E are Paracetamol tablets obtained from two different government hospitals .

PowerPoint Presentation:

8 Disintegration Study Experimental condition: Medium: Water, speed 30 cycles per min. Temp.: 37 ± 0.5 0 C. Apparatus model: D-2L (USP). Disintegration time for Paracetamol tablet :- Average disintegration time (min : sec) Brand A Brand B Brand C Brand D Brand E 10:35 1:30 7:40 3:10 6:15

PowerPoint Presentation:

9 Assay Method 20 tablets were Weighted individually & powdered, powder material equiv. to 0.15 gm of Paracetamol was taken with 50ml of 0.1M NaOH & diluted with 100ml of water in 250ml of volumetric flask & volume was made with water, mixed, filtered & 10ml of this solution was diluted to 100ml with water, to 10ml of resulting solution 10ml of 0.1M NaOH was added & diluted to 50ml with water & mixed. Absorbency of resulting solution was measured at 257nm spectrophotometrically.

PowerPoint Presentation:

10 Hardness, Friability & Weight variation: Friability: % Friability = Weight variation: within ± 5.0% limit as per I.P. % Friability, Hardness & Assay of Paracetamol :- I – F x 100 I Brands % Friability Hardness (Kg/cm 2 ) Assay A 0.56% 5.3 97.14% W/W B 0.98 % 4.6 99.01% W/W C 1.02 % 3.6 100.60% W/W D 0.81 % 3.5 96.53% W/W E 0.91 % 4.2 98.38% W/W

Result & Discussion :

11 Result & Discussion All the product complied with std. for friability, hardness, weight variation, disintegration, dissolution & assay except brand C which did not comply with test for friability. The dissolution pattern was found to be varying for each product, but within the prescribed limit. From the results obtained it is cleared that, the overall quality of govt. hospital supplied tablet is comparable with popular marketed brand.

Conclusion:

12 Conclusion This study shows that even most of the professionals think that the quality of Government hospital supplied medicine is poor. But this experimental study will help to change the view of people towards the Government supplied drug.

REFERENCES…:

13 REFERENCES… Government of India, Ministry of Health & Family welfare, The Indian Pharmacopoeia, New Delhi: Controller of Publication, Volume I, 1996, 556. Government of India, Ministry of Health & Family welfare, The Indian Pharmacopoeia, New Delhi: Controller of Publication, Volume II, 1996, A80 - A84. The United State of Pharmacopoeia 24 & National Formulary 19, Asian edition, United State Pharmacopoeial Convention, Rockville, MD, 2000,2148 – 2149. The Pharmaceutical codex, Principle & Practice of Pharmaceutics, 12 th edition, London: Pharmaceutical press, 1994, 987 – 992. Wilson Gisvold’s Textbook of Organic Chemistry, 10 th edition, Lippincott Williams & Wilkins, 1998, 721 – 722. Lachman, L & Lieberman H.A., Theory & Practice of Industrial Pharmacy, 3 rd edition, Mumbai: Varghese publication, 297 – 301. Satoskar, R.S. & Bhandarkar, S.D., Pharmacology & Pharmacotherapeutics, 17 th edition, Mumbai: Popular prakashan, 164 – 165.

PowerPoint Presentation:

14 THANK YOU!

authorStream Live Help