1) LIFE CYCLE 2) PATHOGENESIS 3) CLINICAL FEATURES:
1) LIFE CYCLE 2) PATHOGENESIS 3) CLINICAL FEATURES
LIFE CYCLE:
LIFE CYCLE
CONTD……..:
CONTD……..
PATHOGENESIS:
PATHOGENESIS
CLINICAL FEATURE:
CLINICAL FEATURE A) Febrile illness:- show three successive stages:- Cold stages: last for 15-60 minutes characterised by intense cold and uncontrollable shivering. Hot stage: last for 2-6 hour characterised by high grade fever, severe headache, nausea,vomiting and abdominal discomfort. Sweating stage: last for 2-3hours,charactersized by perfuse sweating.
Contd…:
Contd … The fever recurring at interval of 24 hrs quotidian periodicity, also have been observed in infections with P. vivax and P. malarie . This is due to the maturation of two generation of tertian parasite on two successive days (tertiana duplex) or three generation of quartan parasite maturing on three successive days (quartana triplex). When two generation of quartan parasite mature on successive days. The fever occur on two successive days followed by a day of pyrexia (quartana duplex).
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B) Anemia: After few paraoxysm,anemia of a microcytic or a normocytic hypochronic type develops as a result of breaking down of RBC during segmentation of parasite. C) Splenomegaly : In primary cases, the enlargement is so slight as to escape detected by palpitation. After some paroxysm and usually by a 2 nd week, it is definitely enlarged and palpable.
Complication of P. falciparum::
Complication of P. falciparum : A) Cerebral malaria B) Algid malaria C) Septicemic malaria D) Black water fever
A. Cerebral malaria:
A. Cerebral malaria Dilation and congestion of capillaries. Perivascular hemorrhage having crying appearances. The RBC of hemorrhage are not parasitised . Scattered area of softening. Later soften area are invaded by glial cells called malaria granuloma . Characterised by hyperpyrexia, convulsion, coma and paralysis.