PROBLEMS IN TABLET MANUFACTURING

Views:
 
     
 

Presentation Description

No description available.

Comments

By: bapujipharmacy (34 month(s) ago)

Very nice presentation.. Please can u snd this ppt..? email:sanju.m007@gmail.com

By: yomeshpatel (35 month(s) ago)

dear this is yomesh patel from RND Alembic Research Centre. can you share this presentation with me. my mail id is yomesh.patel@alembic.co.in

By: zainG (37 month(s) ago)

hlo..sir i shall request you to send me this useful ppt on my mail id zagi_jani@yahoo.com.i shall be thankful to you............................

By: zainG (37 month(s) ago)

hlo..sir i shall request you to send me this useful ppt on my mail id zagi_jani@yahoo.com.i shall be thankful to you............................

By: sunned (37 month(s) ago)

Dear Sir, I would be grateful if you would send me this presentation by e-mail to ynnus_sh@yahoo.com

See all

Presentation Transcript

PROBLEMS CAUSES AND REMEDIES IN TABLET MANUFACTURING : 

PROBLEMS CAUSES AND REMEDIES IN TABLET MANUFACTURING NADANASABAPATHI.P., M.Pharm Jr.Research.asst APEX LABS,CHENNAI.

Problem in tablets are either related to imperfections in any one or more of the following factors: : 

Problem in tablets are either related to imperfections in any one or more of the following factors: I. Tableting Process II. Excipient III. Machine

Process related problems : : 

Process related problems : CAPPING: It is due air-entrapment in the granular material. LAMINATION: It is due air-entrapment in the granular material. CRACKING: It is due to rapid expansion of tablets when deep concave punches are used.

Excipient related problems : : 

Excipient related problems : CHIPPING: It is due to very dry granules. STICKING: It is due to excess moisture presnt in the granules. PICKING: It is due the improper dring of the granules. BINDING: It is due the excessive binder present in the granules.

Machine related problems : : 

Machine related problems : DOUBLE IMPRESSION: It is due to free rotation of the punches, which have some engraving on the punch faces.

CAPPING: : 

CAPPING: Capping happened when the upper or lower segment of the tablet separates horizontally, either partially or completely from the main body of a tablet and comes off as a cap, during ejection from the tablet press, or during subsequent handling. Reason: Capping is usually due to the air–entrapment in a compact during compression, and subsequent expansion of tablet on ejection of a tablet from a die.

CAPPING RELATED TO ‘FORMULATION’ (GRANULATION) : 

CAPPING RELATED TO ‘FORMULATION’ (GRANULATION)

CAPPING RELATED TO ‘MACHINE’ (DIES, PUNCHES AND TABLET PRESS) : 

CAPPING RELATED TO ‘MACHINE’ (DIES, PUNCHES AND TABLET PRESS)

Lamination / Laminating : 

Lamination / Laminating Definition: ‘Lamination’ is the separation of a tablet into two or more distinct horizontal layers. Reason: Air–entrapment during compression and subsequent release on ejection. The condition is exaggerated by higher speed of turret.

LAMINATION RELATED TO FORMULATION (GRANULATION) : 

LAMINATION RELATED TO FORMULATION (GRANULATION) Lamination related to MACHINE (Dies, Punches and Tablet Press)

Chipping : 

Chipping Definition: ‘Chipping’ is defined as the breaking of tablet edges, while the tablet leaves the press or during subsequent handling and coating operations. Reason: Incorrect machine settings, specially mis-set ejection take-off.

CHIPPING RELATED TO FORMULATION (GRANULATION) : 

CHIPPING RELATED TO FORMULATION (GRANULATION) CHIPPING RELATED TO MACHINE (DIES, PUNCHES AND TABLET PRESS)

Cracking : 

Cracking Definition: Small, fine cracks observed on the upper and lower central surface of tablets, or very rarely on the sidewall are referred to as ‘Cracks’. Reason: It is observed as a result of rapid expansion of tablets, especially when deep concave punches are used.

CRACKING RELATED TO FORMULATION (GRANULATION) : 

CRACKING RELATED TO FORMULATION (GRANULATION) CRACKING RELATED TO MACHINE (DIES, PUNCHES AND TABLETPRESS)

Sticking : 

Sticking Definition: ‘Sticking’ refers to the tablet material adhering to the die wall. Filming is a slow form of sticking and is largely due to excess moisture in the granulation. Reason: Improperly dried or improperly lubricated granules.

STICKING RELATED TO FORMULATION (GRANULATION) : 

STICKING RELATED TO FORMULATION (GRANULATION)

STICKING RELATED TO MACHINE (DIES, PUNCHES AND TABLET PRESS) : 

STICKING RELATED TO MACHINE (DIES, PUNCHES AND TABLET PRESS)

Picking : 

Picking Definition: ‘Picking’ is the term used when a small amount of material from a tablet is sticking to and being removed off from the tablet-surface by a punch face. The problem is more prevalent on the upper punch faces than on the lower ones. The problem worsens, if tablets are repeatedly manufactured in this station of tooling because of the more and more material getting added to the already stuck material on the punch face. Reason: Picking is of particular concern when punch tips have engraving or embossing letters, as well as the granular material is improperly dried.

PICKING RELATED TO FORMULATION (GRANULATION) : 

PICKING RELATED TO FORMULATION (GRANULATION)

PICKING RELATED TO MACHINE (DIES, PUNCHES AND TABLET PRESS) : 

PICKING RELATED TO MACHINE (DIES, PUNCHES AND TABLET PRESS)

Binding : 

Binding Definition: ‘Binding’ in the die, is the term used when the tablets adhere, seize or tear in the die. A film is formed in the die and ejection of tablet is hindered. With excessive binding, the tablet sides are cracked and it may crumble apart. Reason: Binding is usually due to excessive amount of moisture in granules, lack of lubrication and/or use of worn dies.

BINDING RELATED TO FORMULATION (GRANULATION) : 

BINDING RELATED TO FORMULATION (GRANULATION)

BINDING RELATED TO MACHINE (DIES, PUNCHES AND TABLET PRESS) : 

BINDING RELATED TO MACHINE (DIES, PUNCHES AND TABLET PRESS)

Mottling : 

Mottling Definition: ‘Mottling’ is the term used to describe an unequal distribution of colour on a tablet, with light or dark spots standing out in an otherwise uniform surface. Reason: One cause of mottling may be a coloured drug, whose colour differs from the colour of excipients used for granulation of a tablet.

Causes And Remedies Of Mottling: : 

Causes And Remedies Of Mottling:

Double impression Double impression : 

Double impression Double impression Definition: ‘Double Impression’ involves only those punches, which have a monogram or other engraving on them. Reason: At the moment of compression, the tablet receives the imprint of the punch. Now, on some machines, the lower punch freely drops and travels uncontrolled for a short distance before riding up the ejection cam to push the tablet out of the die, now during this free travel, the punch rotates and at this point, the punch may make a new impression on the bottom of the tablet, resulting in ‘Double Impression’. If the upper punch is uncontrolled, it can rotate during the short travel to the final compression stage and create a double impression.

CAUSES AND REMEDIES OF DOUBLE IMPRESSION: : 

CAUSES AND REMEDIES OF DOUBLE IMPRESSION:

Slide 28: 

THANK YOU