logging in or signing up NANO SUSPENSIONS robin_vinnu Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 1230 Category: Education License: All Rights Reserved Like it (0) Dislike it (0) Added: October 31, 2010 This Presentation is Public Favorites: 1 Presentation Description No description available. Comments Posting comment... By: radhebhumiputra (7 month(s) ago) n Saving..... Post Reply Close Saving..... Edit Comment Close By: saichattu (11 month(s) ago) Hai sir gud mrng. I need this articel can u send me the presentation to my email. saichattu@live.com Saving..... Post Reply Close Saving..... Edit Comment Close By: psmani (11 month(s) ago) hello sir i need this article ......do the needful this my mail id manikandanmpharm@gmail.com Saving..... Post Reply Close Saving..... Edit Comment Close By: hnchavda (13 month(s) ago) good ppt.can i download the same or can you send me the same at my email address mentioned below? hemantchavda1988@gmail.com Saving..... Post Reply Close Saving..... Edit Comment Close By: virhoom (14 month(s) ago) good Saving..... Post Reply Close Saving..... Edit Comment Close loading.... See all Premium member Presentation Transcript Slide 1: NANO SUSPENSIONS Slide 2: Introduction Solubility is an important property for drug formulation and their effectiveness. One of the main problem of new molecular entities as drug formulations is poor solubility. Nano Suspension technology can be used to improve the stability as well as the bioavailability of poorly soluble drugs. Slide 3: WHAT ARE NANO SUPENSIONS? Nano Suspensions are the biphasic colloidal dispersions of nanosized drug particles stabilized by surfactants. Size of the drug particles is less than 1mm.Average particle size ranges from 200-600nm Slide 5: Preparation of Nano Suspensions: Slide 6: Media Milling: Nano particles are produced using high shear media mills or pearl mills. Size obtained is <200nm Motor Slide 7: Advantages: Narrow sized particles are obtained. Flexibility in handling of drug is seen.i.e from 1 to 400mg/ml. Dis advantages: Residues may occur due to corrosion. Slide 8: High Pressure Homogenisers: The size reduction is brought by cavitation,high shear forces and the collision of the particles against each other. Macrosuspension is passed through a homogenization gap which leads to a high shearing velocity. Slide 9: Advantages: Allows aseptic production of nanosuspensions for parenteral administration. Dis advantages: Prerequisite of micronized drug paticle. Slide 10: Emulsions as Templates Can be prepared by dilution of emulsion with water. Also by evaporation of organic phase under reduced pressure to give nanosuspensions. Advantage of this method is specialized equipment is not used. Slide 11: Characteristics of Nanosuspensions Size and distribution Particle charge Crystalline status Dissolution velocity Saturation solubility Slide 12: Based on in-vitro Behaviour: Properties to be included are…. Adhesion properties(in case of mucoadhesive particles) Surface hydrophilicity. Interactions with body proteins. Slide 13: In-vivo studies: Surface Hydrophilicity / Hydrophobicity properties are considered. Slide 14: Action of nano particles: The nano particles binds with the opsonis (immunoglobulins) and forms the opsonised nano particles. Recognition by cytoplasmic membrane receptors. Entry into pseudopod extensions on membrane. Slide 15: Release of phagosome into cytoplasm. Formation of phagolysosome by binding with lysosomes. Release of the nano drug particle into extracellular region. Slide 16: USES OF NANOSUSPENSIONS Anti Cancer Anti Infective Anti-Emetic Anti -Asthmatic agent Immuno- suppressants and Lipid Lowering Substances Slide 17: CONCLUSION: This technology is gaining significance as the number of molecules with solubility and bioavailability problems are increasing day by day. Thus, Nanosuspension technology can paly a vital role indrug discovery programs as well as increasing the bioavailability of poorly soluble drugs You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
NANO SUSPENSIONS robin_vinnu Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 1230 Category: Education License: All Rights Reserved Like it (0) Dislike it (0) Added: October 31, 2010 This Presentation is Public Favorites: 1 Presentation Description No description available. Comments Posting comment... By: radhebhumiputra (7 month(s) ago) n Saving..... Post Reply Close Saving..... Edit Comment Close By: saichattu (11 month(s) ago) Hai sir gud mrng. I need this articel can u send me the presentation to my email. saichattu@live.com Saving..... Post Reply Close Saving..... Edit Comment Close By: psmani (11 month(s) ago) hello sir i need this article ......do the needful this my mail id manikandanmpharm@gmail.com Saving..... Post Reply Close Saving..... Edit Comment Close By: hnchavda (13 month(s) ago) good ppt.can i download the same or can you send me the same at my email address mentioned below? hemantchavda1988@gmail.com Saving..... Post Reply Close Saving..... Edit Comment Close By: virhoom (14 month(s) ago) good Saving..... Post Reply Close Saving..... Edit Comment Close loading.... See all Premium member Presentation Transcript Slide 1: NANO SUSPENSIONS Slide 2: Introduction Solubility is an important property for drug formulation and their effectiveness. One of the main problem of new molecular entities as drug formulations is poor solubility. Nano Suspension technology can be used to improve the stability as well as the bioavailability of poorly soluble drugs. Slide 3: WHAT ARE NANO SUPENSIONS? Nano Suspensions are the biphasic colloidal dispersions of nanosized drug particles stabilized by surfactants. Size of the drug particles is less than 1mm.Average particle size ranges from 200-600nm Slide 5: Preparation of Nano Suspensions: Slide 6: Media Milling: Nano particles are produced using high shear media mills or pearl mills. Size obtained is <200nm Motor Slide 7: Advantages: Narrow sized particles are obtained. Flexibility in handling of drug is seen.i.e from 1 to 400mg/ml. Dis advantages: Residues may occur due to corrosion. Slide 8: High Pressure Homogenisers: The size reduction is brought by cavitation,high shear forces and the collision of the particles against each other. Macrosuspension is passed through a homogenization gap which leads to a high shearing velocity. Slide 9: Advantages: Allows aseptic production of nanosuspensions for parenteral administration. Dis advantages: Prerequisite of micronized drug paticle. Slide 10: Emulsions as Templates Can be prepared by dilution of emulsion with water. Also by evaporation of organic phase under reduced pressure to give nanosuspensions. Advantage of this method is specialized equipment is not used. Slide 11: Characteristics of Nanosuspensions Size and distribution Particle charge Crystalline status Dissolution velocity Saturation solubility Slide 12: Based on in-vitro Behaviour: Properties to be included are…. Adhesion properties(in case of mucoadhesive particles) Surface hydrophilicity. Interactions with body proteins. Slide 13: In-vivo studies: Surface Hydrophilicity / Hydrophobicity properties are considered. Slide 14: Action of nano particles: The nano particles binds with the opsonis (immunoglobulins) and forms the opsonised nano particles. Recognition by cytoplasmic membrane receptors. Entry into pseudopod extensions on membrane. Slide 15: Release of phagosome into cytoplasm. Formation of phagolysosome by binding with lysosomes. Release of the nano drug particle into extracellular region. Slide 16: USES OF NANOSUSPENSIONS Anti Cancer Anti Infective Anti-Emetic Anti -Asthmatic agent Immuno- suppressants and Lipid Lowering Substances Slide 17: CONCLUSION: This technology is gaining significance as the number of molecules with solubility and bioavailability problems are increasing day by day. Thus, Nanosuspension technology can paly a vital role indrug discovery programs as well as increasing the bioavailability of poorly soluble drugs