MOLECULAR IMAGING

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By, Sandeep.K Nagalakshmi.B Deepika.C MOLECULAR IMAGING

Definition : 

Definition Molecular imaging is the technique that uses sophisticated diagnostic imaging equipment and system to visualize specific signal molecules based on their chemical and biological properties.

Invivo Histology : 

Invivo Histology Many of the diagnostic techniques involve laboratory analysis of blood,sputum etc. whereas molecular imaging serves the purpose in actual environment,the tissue.hence it is known as Invivo Histology.

Purpose? : 

Purpose? Prostate cancer is the 2nd most commonly diagnosed cancer and 4th most causative of deaths among cancers. Diagnosis of prostate cancer initially cames from PSA(prostate specific antigen) blood test,confirmation comes via biopsy. Spreading of tumours –ultra sound.

As a tool: : 

As a tool: It helps particularly to predict which tumour is aggressive or going to invade locally,more severely. Node size is not the criteria of detection.

Treatment: : 

Treatment: Localised tumours-radiotheraphy. Systemic or diffused tumours-chemotheraphy or hormonal theraphy. Amputation in case of person becoming hormone refractory.

EMERGING IMAGING AGENTS: : 

EMERGING IMAGING AGENTS: PSMA(Prostate specific molecular imaging aid) by Ponper. 18F-FDHT(18F-fluoro dihydro testosterone),a thymidine analouge-incorporated in DNA in case of PSArelapse and it’s proliferation is taken as a measure.

PET/CT with Choline: : 

PET/CT with Choline: Positron emission tomography(PET) Computed tomography(CT) 11c-choline is useful to diagnose even in case of biochemical relapse. But it’s half life is very short. Stability can be enhanced by adding 18F.

IMAGING STRATEGIES: : 

IMAGING STRATEGIES: SHORT TERM-cell location FDG(Fluoro deoxy glucose) Indium-111-oxine are the radio nuclides used to label stem cells. LONGTERM-quantitative reporeter gene imaging-herpes virus thymidine kinase enzyme.

Molecular imaging techniques: : 

Molecular imaging techniques: Optical imaging-based on reflection,absorption,fluoroscence.near IR rays are employed. SPECT(single photon emission computed tomography)-Indium111,iodine123 are employed. PET(positron emission tomography)-15O,13N are employed.

Any ………………. : 

Any ……………….