logging in or signing up Filariasis rka10 Download Post to : URL : Related Presentations : Let's Connect Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 1970 Category: Entertainment License: All Rights Reserved Like it (1) Dislike it (0) Added: July 06, 2011 This Presentation is Public Favorites: 2 Presentation Description No description available. Comments Posting comment... By: paulelias1 (30 month(s) ago) I would like to read the presentation. Saving..... Post Reply Close Saving..... Edit Comment Close By: paulelias1 (30 month(s) ago) I would like to read the presentation. Saving..... Post Reply Close Saving..... Edit Comment Close Premium member Presentation Transcript Filariasis: FilariasisIntroduction: Introduction Tissue dwelling Nematodes Wuchereria Bancrofti Brugia Malayi Onchocerca Volvulus Loa LoaVector: Vector Culex fatigans Anopheles / Aedes Mansonides – B. Malayi infection Adult worm – Lymphatic vessels Microfilariae – Blood, Pulmonary capillaries W. BancroftiPathogenesis: Pathogenesis Living adult worm Inflammatory response caused by death of the worm Microfilariae Secondary InfectionPathogenesis: Pathogenesis Inflammatory damage to lymphatics is caused by adult worms and NOT Microfilariae Toxins / inflammatory damage Lymphatic dysfunction Chronic manifestations (Elephantiasis / Hydrocele / secondary infection Microfilaria – TPEClinical Features: Clinical Features Most common presentations Asymptomatic Microfilaremia / Subclinical Acute Filarial Lymphangitis (ADL) Hydrocele Chronic Lymphatic Disease Tropical Pulmonary EosinophiliaAsymptomatic / Subclinical: Asymptomatic / Subclinical Endemic areas Microscopic hematuria and / or proteinuria Dilated and tortous lymphatics – imaging Large number of circulating MFAcute Filarial Lymphangitis: Acute Filarial Lymphangitis High fever Lymphatic inflammation (Pain / redness / tenderness / retrograde) Local oedema Enlarged, painful, tender regional lymphnodes Upper and lower extremitiesAcute Filarial Lymphangitis: Acute Filarial Lymphangitis Genital Lymphatic – W. Bancrofti Funiculitis Epididymitis Scrotal pain and tenderness More acute and intense in newly exposed individuals than in natives of endemic areas Acute attacks are short lived and not accompanied by feverChronic Lymphatic Disease: Chronic Lymphatic Disease Elephantiasis Chyluria Intermittent Most prominent in the morning Chylous ascites, Chylous Pleural effusion Scrotal oedemaInvestigation: Investigation Definite diagnosis – parasite detection Microfilariae Blood (Nocturnal) Hydrocele Adult worms Lymphatic vessels / Nodes “Filaria dance sign”Investigation: Investigation Eosinophilia Serum IgE – elevated Antifilarial antibodies Radionuclide lymphoscintigraphic imaging of limbs Lymphatic abnormalities Not for diagnosis of filarial infection Assessment of lymphoedema of all causesTreatment: Treatment DEC 6 mg/Kg daily in 3 divided doses after food x 12 days Macro & Micro filaricidal properties Single dose may be equally efficacious For acute lymphangitis Antipyretics / Analgesics Antibiotics – if secondary bacterial infections presentTreatment: Treatment Chronic Lymphatic Disease Hygeine Prevention of secondary infections Physiotherapy Prophylactic antibiotic to prevent secondary infection Hydrocele Surgically treatedSide Effects: Side Effects DEC Host response to dying MF Directly proportional to MF load 24 to 36 hours of 1 st dose Fever, chills, headache, nausea, vomiting, arthralgia Antihistamines / corticosteroidsPrevention: Prevention Avoid mosquito bite Mosquito control programmes Mass annual distribution of Albendazole + DEC Salt fortified with DECTropical Pulmonary Eosinophilia: Tropical Pulmonary EosinophiliaClinical Features: Males : Females = 4 : 1 3 rd decade of life Residence in filaria endemic region Paroxysmal cough and wheezing – usually nocturnal Low grade fever Weight loss Lymphadenopathy Clinical FeaturesInvestigations: Investigations Eosinophilia Circulating microfilaria – NOT found Chest X- Ray Normal Bronchovascular markings Diffuse miliary lesionsInvestigations: Investigations PFT:- Restrictive abnormality in most Serum IgE level – Elevated Antifilarial antibodiesPathogenesis: Pathogenesis Rapid clearance of MF from the blood stream by lungs Allergic and inflammatory reactionsPathogenesis: Pathogenesis Not properly treated / untreated Interstitial fibrosis Chronic ILDTreatment: Treatment DEC 6 mg/Kg / day in divided doses x 14 days Symptoms usually resolve within 3 to 7 days Relapse (which occurs rarely)– retreatment You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.