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UP TO 50% MORTALITY RATE IN UNTREATED PATIENTS LISTED AS A POTENT BIOWEAPON BY THE CENTER FOR DISEASE CONTROL MAJOR SYMPTONS AFTER 3-5 DAYS OF EXPOSURE FATAL SYMPTOMS AFTER 2 WEEKS Figure 1. a http://pathmicro.med.sc.edu/ghaffar/zoonoses.htm .
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PROBLEM Current methods of diagnosis take up to two weeks for accurate results, and present several safety hazards to laboratory personnel.
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TUL4 http://www.niaid.nih.gov/SiteCollectionImages/labs_scientific/labs/aboutlabs/licp/Fig1_Celli_Francisella_image.jpg
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GOAL TO DEVELOP A DIAGNOSTIC TEST TO DETECT TUL4 IN URINE
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NANOPARTICLES SMALL PROTEINS LARGE PROTEINS DYE
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METHODS HRP
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RESULTS MW L P S MW 16.2 kDa 26 kDa 31 kDa 78 kDa 107 kDa 229 kDa 16.2 kDa 26 kDa 31 kDa 78 kDa 107 kDa 229 kDa 19 kDa protein MW L S P 16.2 kDa 26 kDa 31 kDa 78 kDa 107 kDa 229 kDa 46 kDa Tul4
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APPLICATION URINE CONTAINER FILTER NANOPARTICLE STRIP CHARGE GRADIENT ELECTRO-ELUTION CHAMBER COLOR STRIP TEST STRIP
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CONCLUSION BYPASS SAFETY HAZARDS SHORTEN DIAGNOSTIC TIME FROM 2 WEEKS TO 2 HOURS PRESENT AN IDEA FOR A CLINICAL APPLICATION THAT SHORTENS THE TIME TO 20 MINUTES