logging in or signing up toxico-pathological effects of intramuscular administration of gentami razadrpk Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 90 Category: Education License: All Rights Reserved Like it (0) Dislike it (0) Added: July 30, 2010 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript Toxico-Pathological Effects of Intramuscular Administration of Gentamicin in Day-Old Broiler ChicksByMuhammad Kashif Saleemidepts. Veterinary PathologyUniversity of Agriculture FaisalabadPAKISTAN : Toxico-Pathological Effects of Intramuscular Administration of Gentamicin in Day-Old Broiler ChicksByMuhammad Kashif Saleemidepts. Veterinary PathologyUniversity of Agriculture FaisalabadPAKISTAN Slide 2: INTRODUCTION Gentamicin, an aminoglycoside Antibacterial activity against different isolates from clinical infections of poultry (Giurov, 1985 and 1986, Jonas et al ., 2001) Co-administration with Mereks disease vaccine at dose level of 0.2 mg per chick also reported (Edison et al., 1978) Slide 3: Gentamicin unofficially injected into day old chicks to prevent early mortality Gentamicin also administered along with vaccines in Pakistan Unsolved cases of enlarged kidneys and livers in poultry birds suspected for toxicity with unknown causes (Qureshi, 1998) Slide 4: Long retention time in body tissues in muscles and livers of turkeys (Shem-Tov et al., 2003) Not allowed in chicken intended for food Used in pet birds and breeding flocks not intended for human consumption Slide 5: OBJECTIVES Scanty information about Gentamicin induced toxico-pathological changes associated in avian species prompted to study its induced pathological effects in chicks Slide 6: MATERIALS AND METHODS Total of 150 day old broiler chicks (Hubbard Classic) kept on rice husk litter Birds fed corn soybean meal based feed having 22 % total protein Feed and water were provided ad libitum Slide 7: Chicks divided in to 15 groups (A-O) having 10 birds in each group All these birds were administered gentamicin (Gentafar®, 10 % gentamicin as gentamicin sulfate, Farvet, Holland) Duration of experiment five weeks Slide 9: PARAMETERS STUDIED Clinical signs Water and feed intake Body weight Mortality Gross and microscopic pathology Serum chemistry (Total proteins, Albumin, Creatinine, ALT) LD 50 by probit analysis Slide 10: RESULTS Clinical signs and behavioral alterations Birds from groups A-C (0-20 mg/kg) No clinical signs Depression, off feed birds in in Group D (30 mg/kg) 2/10, Groups E &F (40 & 50 mg/kg) 4/10 Group G-J (60-90) More than half of the birds deprssed, profuse diarrhea, sitting on hocks Slide 11: Groups K-O (100-180 mg/kg) All birds intensely depressed, diarrhea and off feed, water intake increased Slide 12: Mortality Slide 13: FEED CONSUMPTION (g/bird/day) Slide 14: BODY WEIGHTS OF BROILERS (g) Serum biochemical parameters of day old broiler administered various levels of gentamicin (Mean ±SD) : Serum biochemical parameters of day old broiler administered various levels of gentamicin (Mean ±SD) PATHOLOGY : PATHOLOGY KIDNEYS groups A-E no changes groups F-H moderate swelling, congestion, hemorrhages In groups I-O severe swelling bulged out, congestion, hemorrhages Microscopically all groups had parenchymal congestion necrotic epithelial cells of convoluted tubules Slide 17: LIVERS groups A-E no changes Groups F-L moderate enlargement, congestion, friable In Groups M-O Maximum enlargement, friable, hemorrhages on surface Slide 18: Groups F-J kidneys showed moderate Liver showed of the birds of groups A, B and D did not exhibit any deviation from the normal histological pattern. Slide 19: Microscopically Group E fatty change only Groups F-H fatty change, congestion, of sinosiodal spaces, hetrophilic Aggregates of around triads. Necrotic areas in the parenchyma Slide 20: Figure 1: Pyknotic and necrotic changes in glomeruli and tubules of day old broiler chicks (H&E staining) (10X) Slide 21: Figure 2: Liver of day old broilers showing hemorrhages and congestion in hepatic triad nuclei of hepatocytes are pyknotic and necrotic changes in hepatocytes (H&E staining) (100X) You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
toxico-pathological effects of intramuscular administration of gentami razadrpk Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 90 Category: Education License: All Rights Reserved Like it (0) Dislike it (0) Added: July 30, 2010 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript Toxico-Pathological Effects of Intramuscular Administration of Gentamicin in Day-Old Broiler ChicksByMuhammad Kashif Saleemidepts. Veterinary PathologyUniversity of Agriculture FaisalabadPAKISTAN : Toxico-Pathological Effects of Intramuscular Administration of Gentamicin in Day-Old Broiler ChicksByMuhammad Kashif Saleemidepts. Veterinary PathologyUniversity of Agriculture FaisalabadPAKISTAN Slide 2: INTRODUCTION Gentamicin, an aminoglycoside Antibacterial activity against different isolates from clinical infections of poultry (Giurov, 1985 and 1986, Jonas et al ., 2001) Co-administration with Mereks disease vaccine at dose level of 0.2 mg per chick also reported (Edison et al., 1978) Slide 3: Gentamicin unofficially injected into day old chicks to prevent early mortality Gentamicin also administered along with vaccines in Pakistan Unsolved cases of enlarged kidneys and livers in poultry birds suspected for toxicity with unknown causes (Qureshi, 1998) Slide 4: Long retention time in body tissues in muscles and livers of turkeys (Shem-Tov et al., 2003) Not allowed in chicken intended for food Used in pet birds and breeding flocks not intended for human consumption Slide 5: OBJECTIVES Scanty information about Gentamicin induced toxico-pathological changes associated in avian species prompted to study its induced pathological effects in chicks Slide 6: MATERIALS AND METHODS Total of 150 day old broiler chicks (Hubbard Classic) kept on rice husk litter Birds fed corn soybean meal based feed having 22 % total protein Feed and water were provided ad libitum Slide 7: Chicks divided in to 15 groups (A-O) having 10 birds in each group All these birds were administered gentamicin (Gentafar®, 10 % gentamicin as gentamicin sulfate, Farvet, Holland) Duration of experiment five weeks Slide 9: PARAMETERS STUDIED Clinical signs Water and feed intake Body weight Mortality Gross and microscopic pathology Serum chemistry (Total proteins, Albumin, Creatinine, ALT) LD 50 by probit analysis Slide 10: RESULTS Clinical signs and behavioral alterations Birds from groups A-C (0-20 mg/kg) No clinical signs Depression, off feed birds in in Group D (30 mg/kg) 2/10, Groups E &F (40 & 50 mg/kg) 4/10 Group G-J (60-90) More than half of the birds deprssed, profuse diarrhea, sitting on hocks Slide 11: Groups K-O (100-180 mg/kg) All birds intensely depressed, diarrhea and off feed, water intake increased Slide 12: Mortality Slide 13: FEED CONSUMPTION (g/bird/day) Slide 14: BODY WEIGHTS OF BROILERS (g) Serum biochemical parameters of day old broiler administered various levels of gentamicin (Mean ±SD) : Serum biochemical parameters of day old broiler administered various levels of gentamicin (Mean ±SD) PATHOLOGY : PATHOLOGY KIDNEYS groups A-E no changes groups F-H moderate swelling, congestion, hemorrhages In groups I-O severe swelling bulged out, congestion, hemorrhages Microscopically all groups had parenchymal congestion necrotic epithelial cells of convoluted tubules Slide 17: LIVERS groups A-E no changes Groups F-L moderate enlargement, congestion, friable In Groups M-O Maximum enlargement, friable, hemorrhages on surface Slide 18: Groups F-J kidneys showed moderate Liver showed of the birds of groups A, B and D did not exhibit any deviation from the normal histological pattern. Slide 19: Microscopically Group E fatty change only Groups F-H fatty change, congestion, of sinosiodal spaces, hetrophilic Aggregates of around triads. Necrotic areas in the parenchyma Slide 20: Figure 1: Pyknotic and necrotic changes in glomeruli and tubules of day old broiler chicks (H&E staining) (10X) Slide 21: Figure 2: Liver of day old broilers showing hemorrhages and congestion in hepatic triad nuclei of hepatocytes are pyknotic and necrotic changes in hepatocytes (H&E staining) (100X)