radiopharmaseutical

Slide 1: 

Radiopharmaceuticals and it's diagnostic applications

Contents of our presentation : 

Contents of our presentation Introduction to radiopharmaceuticals What are radioisotopes? Applications of Radiopharmaceutical Chemistry on Disease Diagnosis radioimmunoscintigraphy of breast cancer: Other diagnostic applications of radiopharmaceuticals Radiopharmaceuticals administration What are the radiation risks associated with nuclear medicine examinations?

Radiopharmaceuticals : 

Radiopharmaceuticals The combination of the radionuclide bound to a molecule or compound is known as a radiopharmaceutical . Radionuclides, to achieve stability, decay disintegrate at a constant rate.

What are radioisotopes? : 

The isotopes of an element have the same atomic number but different mass number. The nucleus becomes stable by emitting an alpha ,beta particle or gamma rays. Radionuclides are synthetic and fall into 4 general categories: Generator-produced, Fission reactor-produced, Thermal Neutron Reactor-produced, Cyclotron-produced. What are radioisotopes?

Applications of Radiopharmaceutical Chemistry on Disease Diagnosis : 

Applications of Radiopharmaceutical Chemistry on Disease Diagnosis Nuclear medicine procedures are capable of mapping physiological function and metabolic activity so give more specific information about the organ function and dysfunction.

1-A new monoclonal antibody radiopharmaceutical for radioimmunoscintigraphy of breast cancer (cont.): : 

1-A new monoclonal antibody radiopharmaceutical for radioimmunoscintigraphy of breast cancer (cont.): There are two general methods for labeling of an antibody with 99mTc ( direct and indirect methods). general scheme for direct radio labeling procedure Reduction of Map by 2-ME and binding of 99mTc to it via MDP:

2-Other diagnostic applications of radiopharmaceuticals : 

2-Other diagnostic applications of radiopharmaceuticals Bone scanning Brain scanning Renal scintigraphy Thyroid scanning

Other diagnostic applications of radiopharmaceuticals (cont.) : 

Other diagnostic applications of radiopharmaceuticals (cont.) Perfusion lung scanning Myocardial perfusion scanning:

Properties of the ideal diagnostic radiopharmaceutical : 

Properties of the ideal diagnostic radiopharmaceutical 1. pure gamma emitter 2. Effective half-life. 3. Minimal radiation dose to patient 4. Patient Safety 5. Inexpensive, readily available radiopharmaceutical. 6.Simple preparation and quality control if manufactured

Radiopharmaceuticals administration : 

Radiopharmaceuticals administration Radiopharmaceuticals are administered in small mass amounts, generally nanomoles. Imaging agents have little or no pharmacologic effect. radiation dose must be below the threshold for any acute radiation toxicity.

What are the radiation risks associated with nuclear medicine examinations? : 

What are the radiation risks associated with nuclear medicine examinations? In cases of extravascular injection could be considered an accidental exposure Can a patient who is breastfeeding a baby continue to do so?

What are the radiation risks associated with nuclear medicine examinations? (cont.) : 

What are the radiation risks associated with nuclear medicine examinations? (cont.) Can patient protection be considered in the selection of radiopharmaceuticals?

Referances : 

Referances 1-Nuclear application in health care by Steffen Groth 2-Potamianos S, Varvarigou AD, Archimandritis SC. Radioimmunoscintigraphy and radioimmunotherapy in cancer: principles and application. Anticancer Res 2000; 20: 925-948. 3-New horizons in radiopharmaceutical by Stephen J.Mather 4-http:// www.norcalindustrial.com 5-http://www.Britannica.com 8-http://www.isotop.com 6-http://science.irank.org 7-http://www.meddean.luc.edu 9-http://www.snm.org

The Titans : 

The Titans Raghda Reyad 201 Raghda Mohamed 202 Rofaida Ahmed 203 Roqaya Qamar 204 Roqaya Mohamed 205 Rana Ahmed 206 Rana Ramadan 207 Rana Raafat 208 Rana Sadek 209 Rana Tarek 210 Sara Ismail 230

Slide 15: 

Thank you