rosvu ppt

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Rosuvastatin 6/30/2011 ROSUVASTATIN (Hypolipidaemic Drug) Presented By - Rajdeep L. Vaishnav M.pharm – 1st sem.( p.cology )

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Rosuvastatin 6/30/2011 Contents Introduction Mechanism of action Pharmacological action Adverse effect Contra-indication Dose Current clinical research trials (Jupiter study)

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Rosuvastatin Introduction : Hypolipidaemic drugs are which lowers lipid level This are the drug have potency to prevent c.v. disease by retarding acceleration of atherosclerosis in individual. Statins are categorized into HMG-CoA reductase inhibitors. Eg: Atorvastatin, Rosuvastatin, Pravastatin, Simvastatin. 6/30/2011

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Rosuvastatin Rosuvastatin- Latest & potent(10mg.ros≈20mg.ator.) LDL-CH.(20-50%) Reduction in severe hypercholesterolemia Raise the level of TG & HDL-CH.by 15-20% 6/30/2011

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Rosuvastatin Mechanism of action: 2 Acetyl CoA Thiolase Acetoacetyl CoA HMG-CoA synthase β -hydroxy β -methylglutaryl CoA(HMG-CoA) Rosuvastatin ѳ HMG-CoA reductase Mevalonate Cholesterol ↑se Hepatic LDL-receptor on the cell surface ѳ = inhibition 6/30/2011

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Rosuvastatin Pharmacological Action Competitively ѳ conversion of HMG-CoA – to Mevalonate by enzyme HMG-CoA reductase ↑ se in LDL receptor expression on liver cell ↑ se receptor mediated uptake & catabolism of IDL & LDL 6/30/2011

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Rosuvastatin Pharmacokinetic Bioavailability : 35 – 40 % Metabolism : Liver Half life : 19 hrs Excretion : Urine (majorly) , faeces (minor) 6/30/2011

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Rosuvastatin Adverse effect : Rhabdomylosis Muscle pain/weakness (with fever or tiredness) Stomach / abdominal pain Yellowish eye & skin Allergic reaction such as rash , itching , swelling Dizziness Mild nausea 6/30/2011

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Rosuvastatin Contra indication Allergic to statin therapy Kidney disease Liver disease Pregnancy Lactation Alcoholism 6/30/2011

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Rosuvastatin Dose Once in a daily As directed by the Physician High dose required for Intervention 6/30/2011

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Rosuvastatin Brand name : Fortius – 5/10/20mg (NPIL) Novastat - 5/10/20mg (Lupin) Razel – 5/10/20mg (Glenmark) Rosuvas – 5/10/20mg (ranbaxy) Rosuvastat – 1000mg (Dr.Reddy’s) Rovalip - 10mg (Cadila) Rozucor – 5/10mg (Torrent) Rostar – 5/10mg (Unichem) Arvast – 5/10mg (Intas) 6/30/2011

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Rosuvastatin Jupiter Study J ustification for the U se of statins in P rimary p revention : An I ntervention T rial E valuating R osuvastatin Dr.PaulM.Ridker, (bringham & women’s hospital, havardmedischool)Designer for this trial & AstraZeneca-siemens health care diagnostics have supported. Total 17,802 patients were selected for trial 6/30/2011

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Rosuvastatin Men aged 50yr & older women aged 60 yrs with have LDL-C<130mg/dl & hs CRP ≥2mg/l Main observation : ↓ LDL-C & hs CRP level & red.in mortality. Result : trial conduct over 1.9yr , Rosuvastatin reduced LDL-C by 50%, hs CRP by 37% in patients compared to placebo group. As a Hypolipidaemic drug it also halts/reduced MI by 54%,strock by 48%,revascularization by 47%, Cardiac death BY 20%. 6/30/2011

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Rosuvastatin References Biochemistry by – U.Satyanarayana Essential of medical pharmacology by- K.D.Tripathi 5 th edition WWW.LIPIDSONLINE.COM WWW.NEMJ.COM WWW.EMEDICINEHEALH.COM WWW.ROSUVASTATININFORMATION.COM WWW.EXPRESSPHARMAONLINE.COM CIMS 6/30/2011