drug-drug interaction

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By: muralichalla (44 month(s) ago)

Dear Dr. Ravi garu, Can you send me the PPT on Seminar on drug interactions Kindly send me to drmurali@gitam.edu Thank you, Yours faithfully Murali

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i want to download this ppt please.

By: drahmedshams2011 (44 month(s) ago)

Thanks for your great effort

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thanks a lot

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Presentation Transcript

Seminar On Drug Interactions : 

Seminar On Drug Interactions Submitted by: Vasudha Abbhi Submitted to: Dr. Ravi Shanbhogue

CONTENTS : 

CONTENTS Introduction Objective Definition Mechanisms: Pharmacokinetics drug interactions Pharmacodynamic drug interactions Significance

INTRODUCTION : 

INTRODUCTION Alteration of pharmacological effect FACTORS RESPONSIBLE: Polypharmacy Multiple physicians Concurrent use of drugs Drug abuse

OBJECTIVE : 

OBJECTIVE Safe Drug Therapy

Drug interactions : 

Drug interactions Modification of effect. Commonly involved drugs: Warfarin, phenytoin Digoxin, oral contraceptives etc. Sites and mechanisms: Invitro interactions Invivo interactions: Pharmacokinetic pharmacodynamic

Pharmacokinetic interactions : 

Pharmacokinetic interactions Altered ADME Interaction during absorption Interaction during distribution Interaction during metabolism Interaction during excretion

Absorption : 

Absorption In the gut: Tetracycline + calcium salts GIT motility- anticholinergics pH- antacids Gut flora- antimicrobials

Distribution : 

Distribution

Metabolism : 

Metabolism Enzyme inducer Phenytoin Enzyme inhibitor chloramphenicol

Excretion : 

Excretion

Pharmacodynamic interactions : 

Pharmacodynamic interactions

Significance : 

Significance Measurable precautions

Refrences : 

Refrences Essentials of pharmacology- V.N. Sharma Pg no. 40-43 Textbook of medical pharmacology- Padmaja Udaykumar Pg no. 51-53 Goodman and Gilmans Pg no. 1739-1740

THANK : 

THANK YOU