logging in or signing up clinical pharmacokinetic preciousmolu Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 613 Category: Education License: All Rights Reserved Like it (1) Dislike it (0) Added: September 12, 2010 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... By: sadhnasandhya (7 month(s) ago) please send a copy of this presentation to sadhnasandhya@gmail.com. thank you. Saving..... Post Reply Close Saving..... Edit Comment Close By: pharmacistiraqi (11 month(s) ago) i want to download this slide thanks Saving..... Post Reply Close Saving..... Edit Comment Close By: addkbd11 (17 month(s) ago) i want to down load this slide thanks Saving..... Post Reply Close Saving..... Edit Comment Close By: addkbd11 (17 month(s) ago) please release this slide Saving..... Post Reply Close Saving..... Edit Comment Close By: addkbd11 (17 month(s) ago) please release this slide Saving..... Post Reply Close Saving..... Edit Comment Close loading.... See all Premium member Presentation Transcript Slide 1: A Seminar on Clinical Pharmacokinetics Guide :- Submitted by:- Dr. Ravi Shanbhogue Ajay Thakur INDEX : INDEX Introduction Half- life Steady state Clearance Volume of distribution Significance Clinical Pharmacokinetics : Clinical Pharmacokinetics Study of movement of drugs Affected by: Absorption Distribution Metabolism Excretion Absorption : Absorption Movement of drug from site of administation to systemic circulation Time to Peak Concentration : Time to Peak Concentration Distribution : Distribution Movement of drugs between the compartments Metabolism : Metabolism Conversion of one form of drug into another Mainly takes place in liver Types of metabolic reaction Phase I (Cytochrome P450 system) Phase II Steady state : Steady state Steady State: the amount of drug administered is equal to the amount of drug eliminated within one dosing interval resulting in a plateau or constant serum drug level Drugs with short half-life reach steady state rapidly; drugs with long half-life take days to weeks to reach steady state Half-life : Half-life t ½= time required for serum plasma concentrations to decrease by one-half (50%) 4-5 half-lives to reach steady state Clearance : Clearance Theoretical volume of the plasma from which the drug is completely removed in unit time CL=rate of elimination /C Types of clearance Renal clearance Hepatic clearance Clearance : Clearance Clrenal+ CLhepatic+ CLother =CL RENAL CLEARANCE= Rate of urinary excretion/plasma drug concentartion Volume of distribution : Volume of distribution Accommodate all the drug in the body V=dose administered i.v./plasma concentration Why Study Pharmacokinetics (pk) : Why Study Pharmacokinetics (pk) Individualize patient drug therapy Monitor medications with a narrow therapeutic index Decrease the risk of adverse effects Evaluate pk/pd as a diagnostic tool Used in study of clinical trials THANK YOU : THANK YOU You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
clinical pharmacokinetic preciousmolu Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 613 Category: Education License: All Rights Reserved Like it (1) Dislike it (0) Added: September 12, 2010 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... By: sadhnasandhya (7 month(s) ago) please send a copy of this presentation to sadhnasandhya@gmail.com. thank you. Saving..... Post Reply Close Saving..... Edit Comment Close By: pharmacistiraqi (11 month(s) ago) i want to download this slide thanks Saving..... Post Reply Close Saving..... Edit Comment Close By: addkbd11 (17 month(s) ago) i want to down load this slide thanks Saving..... Post Reply Close Saving..... Edit Comment Close By: addkbd11 (17 month(s) ago) please release this slide Saving..... Post Reply Close Saving..... Edit Comment Close By: addkbd11 (17 month(s) ago) please release this slide Saving..... Post Reply Close Saving..... Edit Comment Close loading.... See all Premium member Presentation Transcript Slide 1: A Seminar on Clinical Pharmacokinetics Guide :- Submitted by:- Dr. Ravi Shanbhogue Ajay Thakur INDEX : INDEX Introduction Half- life Steady state Clearance Volume of distribution Significance Clinical Pharmacokinetics : Clinical Pharmacokinetics Study of movement of drugs Affected by: Absorption Distribution Metabolism Excretion Absorption : Absorption Movement of drug from site of administation to systemic circulation Time to Peak Concentration : Time to Peak Concentration Distribution : Distribution Movement of drugs between the compartments Metabolism : Metabolism Conversion of one form of drug into another Mainly takes place in liver Types of metabolic reaction Phase I (Cytochrome P450 system) Phase II Steady state : Steady state Steady State: the amount of drug administered is equal to the amount of drug eliminated within one dosing interval resulting in a plateau or constant serum drug level Drugs with short half-life reach steady state rapidly; drugs with long half-life take days to weeks to reach steady state Half-life : Half-life t ½= time required for serum plasma concentrations to decrease by one-half (50%) 4-5 half-lives to reach steady state Clearance : Clearance Theoretical volume of the plasma from which the drug is completely removed in unit time CL=rate of elimination /C Types of clearance Renal clearance Hepatic clearance Clearance : Clearance Clrenal+ CLhepatic+ CLother =CL RENAL CLEARANCE= Rate of urinary excretion/plasma drug concentartion Volume of distribution : Volume of distribution Accommodate all the drug in the body V=dose administered i.v./plasma concentration Why Study Pharmacokinetics (pk) : Why Study Pharmacokinetics (pk) Individualize patient drug therapy Monitor medications with a narrow therapeutic index Decrease the risk of adverse effects Evaluate pk/pd as a diagnostic tool Used in study of clinical trials THANK YOU : THANK YOU