Migraine recent advances

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Recent advances in Migraine summarized - 2012

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Slide 1: 

Recent advances in Migraine Dr. Pratheep Kottam. MBBS, MD, DM Neurology Assistant Professor in Neurology Department of Neurology MOSC Kolenchery, Kochi, Kerala, India

Topic will be discussed under following headings : 

Topic will be discussed under following headings Introduction Clinical features Classification Pathophysiology Investigations Treatment

Slide 3: 

Introduction

Slide 4: 

Definition of Migraine Primary headache Episodic disorder with headache attacks Highly disabling chronic progressive disorder IHS: Disorder characterized by intermittent attacks of headache combined with autonomic disturbances

Epidemiology of Migraine : 

Epidemiology of Migraine Sources: CDC, NHANES III, NHIS, Office for National Statistics, Literature. Migraine is more common than arthritis, asthma, or diabetes

Slide 6: 

Global Prevalence of Migraine Believed to affect up to 17% of females and 6% of males Yet under diagnosed, under- treated & poorly understood Represents a significant burden to society

Slide 7: 

Disability of migraine “WHO rates severe migraine along with quadriplegia, psychosis & dementia as one of the most disabling chronic disorders.” (Archives of Neurology, 2000) Lipton RB et al. Headache. 2001;41:638-645. Functional impairment in 92% & severe impairment in 53%

Slide 8: 

Disability of migraine… 31% patients lose at least 1 day of work & 76% lose at least 1 day of household activities every 3 months 51% report that work or school productivity is reduced by half & may decrease even more as pain intensifies

Slide 9: 

Clinical features

Slide 10: 

Diagnosis of migraine can be challenging Diagnosis by exclusion No consistent physical findings, no biological markers, relies on history alone Previous diagnostic criteria are overlapping, confusing & inconclusive Often misdiagnosed as tension-type headache

Slide 11: 

Profile of migraineurs Females affected 3 times more commonly than men Ages 22 - 55 Most productive, active years But can affect young and elderly Often has family history of migraine Increased chance of suffering attacks if even one parent has migraine

Slide 12: 

Profile of a Migraineur…

Slide 13: 

Lipton RB, et al. Headache. 2001;41:646-657. Reproduced with permission. Profile of a migraineur…

Slide 14: 

Clinical Characteristics 4 stages occurring in sequence, not all patients experience all stages: Prodrome : usually precedes headache by 24 hours Aura : typically resolves in less than 60 minutes Headache : usually unilateral & throbbing, accompanied by nausea, vomiting, photophobia and/or phonophobia, and lasts about 4 to 72 hours Postdrome : occurs after the attack & can last hours to days

Slide 15: 

Four Stages of Migraine Migraine presentation is unique — as many as four stages Prodrome Precedes by 24 hours Euphoria Irritability Sensation changes Local weakness Physical symptoms Aura Visual Sensory Motor Vomiting Abnormal sensations Resolves ~60 minutes Headache Usually unilateral Throbbing Nausea or vomiting Photophobia and phonophobia Persists ~72 hours Postdrome After attack, can last hours to days Exhaustion, or extreme happiness Neurologic, vascular resolve

Slide 16: 

The Migraine Experience

Slide 17: 

Migraine is a diagnosis by history Mostly no signs or investigational findings Exact characterization of headache – most important Drug history - look for rebound headache History – most important

ID Migraine : 

ID Migraine A validated tool useful in migraine screening. 3 screening questions to identify likely migraineurs : 1. Do you have recurrent headaches that interfere with work, family, or social functions? 2. Does your headaches last at least 4 hours? 3. Have you had new or different headaches in the past 6 months? Migraine is considered if patients reply “Yes” to the first 2 questions and “No” to 3rd question.

Slide 19: 

Physical examination Examination may reveal Tender scalp, nasal & paranasal sinuses, & teeth Examination is mainly to rule out other causes of headache Systemic diseases (hypertension, infection) Local tenderness & fever (periostitis 20 to mastoiditis or sinusitis) Ptosis (cluster , brain tumors or aneurysms) Papilledema (increased ICT, expanding ICSOL) Fever, stiff neck (meningitis or encephalitis)

Slide 20: 

Classification

Slide 21: 

IHS classification system: Primary headache Diagnosis of  migraine based on IHS (International Headache Society) classification Primary headache is headache not caused by another disorder Migraine and tension-type account for 75%-90% of primary headache

IHS Classification of Migraine: : 

IHS Classification of Migraine: Probable Migraine without aura Migraine without aura Probable Migraine with aura Migraine with aura Migraine headache + typical aura Typical aura + Non migraine headache Typical aura without headache FHM Sporadic hemiplegic Migraine Basilar Migraine

IHS Classification of Migraine… : 

IHS Classification of Migraine… Childhood periodic syndromes Cyclical vomiting Abdominal migraine BPPV of childhood Retinal Migraine Complicated migraine C/c migraine, Status migranosus Persistent aura Infarction, Seizures Unclassifiable migraine like disorders Cephalalgia 2004;24, S(1)

Slide 25: 

IHS criteria: Migraine without aura >5 attacks fulfilling B to D & not due to another cause. Duration - 4 to 72 hours Headache has at least two of the following features: Unilateral Pulsating Moderate or severe pain intensity Aggravation by routine physical activity like walking During headache at least one of the following: Nausea and/or vomiting Photophobia and phonophobia

Slide 26: 

At least 2 attacks fulfilling at least 3 of the following One / more aura indicating focal brain dysfunction At least 1 aura develop gradually over > 4 minutes OR 2 or more symptoms occur in succession Aura < 60 minutes; if more than 1 aura, duration is proportionally increased Headache follow aura with free interval of less than 60 min (it may begin simultaneously with aura) IHS criteria: Migraine with aura

Usual migraine auras: : 

Usual migraine auras: Homonymous visual disturbance Unilateral paresthesias and/or numbness Unilateral weakness Aphasia or unclassifiable speech difficulty

Fortification spectra of visual auras have been compared to fortified, walled city of Palmanova, Italy : 

Fortification spectra of visual auras have been compared to fortified, walled city of Palmanova, Italy

Artist’s representation of his visual aura. Fortification spectrum associated partial visual loss. : 

Artist’s representation of his visual aura. Fortification spectrum associated partial visual loss.

Progressive central scotoma with a jagged edge : 

Progressive central scotoma with a jagged edge

Motorist’s right hemianopia, scotoma surrounded by a crescentic area of brighter lights. : 

Motorist’s right hemianopia, scotoma surrounded by a crescentic area of brighter lights.

Basilar Migraine : 

Basilar Migraine Children & adolescents Severe occipital headache Features of Basilar occlusion Consciousness impaired - RF Last 10 to 30 min May leave neurologic defects Bickerstaff’s migraine – dramatic form in females With age replaced by migraine without aura

Retinal migraine : 

Retinal migraine Retinal & Anterior optic nerve ischemia Mono ocular visual disturbance followed by headache Photopsia – flashes of light Areas of visual loss, altitudinal defects, transient U/L blindness

Ophthalmoplegic migraine : 

Ophthalmoplegic migraine Child with U/L orbital or retro orbital pain Headache + Extra ocular muscle palsy III nerve > IV nerve / VI nerve IL ptosis progressing to complete III nerve palsy EOM palsy last more than headache MRI – thickening & contrast enhancement of III nerve as it leaves Midbrain May leave permanent neurologic defects

Hemiplegic migraine : 

Hemiplegic migraine Typical migraine with aura + motor weakness during aura Consider only if past h/o migraine with aura is present Typically 30 to 60 minutes - can be hours, days or weeks Recovery usually complete Sporadic or familial Sporadic – side can alternate

Familial hemiplegic migraine : 

Familial hemiplegic migraine Usually same side in each attack AD Chromosome 19 (CACNL4 gene) and 1 Volt gated P/Q Ca Channelopathy +/- Cerebellar signs Acetazolamide to Dec frequency – unproven ? IV Verapamil

Childhood migraine : 

Childhood migraine IHS classification allows diagnosis of childhood migraine for headaches with fewer features. Attacks are shorter than in adults Throbbing quality or unilaterality, photophobia and phonophobia, are less common. Childhood periodic syndromes - cyclical vomiting, abdominal migraine, and benign paroxysmal vertigo of childhood

Slide 38: 

Pathophysiology

Pathophysiology : 

Pathophysiology Theories of migraine pathophysiology have traditionally fallen into two categories: 1. Vasogenic 2. Neurogenic

Classic vascular theory : 

Classic vascular theory Aura caused by intracranial vasoconstriction Headache results from subsequent rebound vasodilatation Theory emerged because: superficial temporal artery pulsations increased in amplitude with increased throbbing quality of pain Ergotamine, a vasoconstrictor, relieved pulsations of the superficial temporal artery and the pain

Slide 41: 

Vascular theory…

Slide 42: 

Physical stress Emotional shockPsychic stress AllergyHormonal imbalance etc. Cerebral hypoxia: the core of “migraine vicious circle” BiochemicalchangesHaematologicalchangesVascularchanges Reactivevasodilatationinducesmigraineattack O2supply O2demand Localizedbrain cellhypoxia Cerebralvasocon-striction andneuronalhyperactivity

Slide 43: 

During cerebral hypoxia calcium overload has been demonstrated clinically and experimentally in: Red blood cells - increased blood viscosity. Contractile elements of vascular endothelium, smooth muscle in vascular walls – vasoconstriction Brain cells - neuronal damage. In migraine there is synergism of all these factors and a vicious cycle is established Cerebral hypoxia

Slide 44: 

Cerebral Hypoxia Reactive Vasodilatation of Cerebral Vessels Migraine Attack

Neurogenic theory of migraine : 

Neurogenic theory of migraine Migraine is due to 10 neuronal dysfunction & vascular changes are only 20. Aura is characterized by a wave of oligemia that passes across the cerebral cortex at a rate of 2 mm to 6 mm per minute - cortical spreading depression Actually spreading activation followed by spreading depression – respect anatomical boundaries, not arterial boundaries Oligemia is a response to depressed neuronal function

Trigeminal-vascular complex : 

Trigeminal-vascular complex Neurogenic inflammation triggered by Trigeminal sensory system Triggered by spreading activation / depression Mediated by Substance P & Calcitonin gene related peptide (CGRP) Trigeminal nucleus caudalis (TNC) & ophthalmic branch of V n important Evidence of platelet aggregation & Serotonin release in migraine attack Role of Serotonin indirectly seen by drug action

Slide 47: 

Neurovascular Theory A stimulus triggers neural events in brainstem This results in dilation of blood vessels & release of inflammatory neuropeptides This stimulate nerves around these blood vessels This nerve involvement sends an impulse through the trigeminal nerve into trigeminal nucleus caudalis. From there it is relayed to the thalamus, where pain is processed From Thalamus to cortex, then to outer layer of brain, where the nerve signals actually become clinical pain

Other concepts : 

Other concepts Dec brain energy metabolism - mitochondrial abnormality Systemic & brain Mg deficiency Gain of NMDA receptor function Brainstem/Hypothalamic generator – MB stimulation near dorsal raphe induces migraine Central sensitization – abnormality in central pain processing Empty neuron hypothesis – genetically mediated inability to maintain normal levels of NT in post ganglionic sympathetic terminals

Summary : 

Summary Migraineurs have a susceptibility to spontaneous depolarization & neuronal hyper excitability Spreading activation Followed by prolonged hypo metabolism due to mitochondrial defect & Mg deficiency Spreading depression Secondary vascular changes contributing to throbbing & pain

Slide 50: 

Investigations

Are investigations needed ? : 

Are investigations needed ? Always rule out dangerous differential diagnoses when - history is not typical - uncommon migraine variants are being considered - when response to treatment is inadequate - when a new type of headache emerges in a patient with migraine

Does this patient with headache need imaging? : 

Does this patient with headache need imaging? 11 studies (n=3,725), were included. Prevalence of abnormality on imaging ranged from 1.2% in c/c headache to 43% in thunderclap headache. Cochrane – structured abstract - 2006

Clinical features predictive of intracranial abnormality : 

Clinical features predictive of intracranial abnormality Headache with aura Headache aggravated by exertion or valsalva Headache with vomiting Cluster-type headache Undefined i.e. not cluster, migraine or tension type Abnormal neurologic examination Cochrane 2006

Clinical features that were not useful in predicting intracranial abnormality : 

Clinical features that were not useful in predicting intracranial abnormality Headache with focal symptoms Worsening of headache Male sex Quick on-set headache New on-set headache Headache with nausea Increased headache severity Migraine-type headache Cochrane 2006

Clinical features with negative predictor value : 

Clinical features with negative predictor value Headache not aggravated by valsalva Absence of vomiting Headache of defined type. BUT – No clinical feature was useful for completely ruling out serious intracranial abnormality. Cochrane 2006

PET in migraine - activation of rostral brainstem structures : 

PET in migraine - activation of rostral brainstem structures

PET in cluster – activation of posterior hypothalamic grey matter : 

PET in cluster – activation of posterior hypothalamic grey matter

PET in experimentally headache – no typical findings : 

PET in experimentally headache – no typical findings

Slide 59: 

Treatment

Advertisement from a US magazine (Harper’s), 1863. : 

Advertisement from a US magazine (Harper’s), 1863.

Headache gone after Wolcott’s treatment : 

Headache gone after Wolcott’s treatment

Slide 62: 

Treatment Acute or abortive therapy Long-term preventive or prophylactic treatment Trigger factor modification Non pharmacologic measures Pharmacologic measures Recent advances

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Acute Therapy DEFINITION: medications taken after migraine attack begins to reduce duration & severity of attack. Often targets blood vessels.

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IHS guidelines for acute therapy Educate & encourage migraineurs to participate in management After NSAIDs, use triptans, DHE (Dihydroergotamine) or ergotamine in patients with severe migraine or in poor NSAID responders Use non-oral route in patients with nausea & vomiting Consider a self-administered rescue medication Guard against medication-overuse headache

Slide 68: 

Acute Therapy: Pros and Cons POSITIVES: Rapid onset of action Relatively inexpensive Ideal for occasional migraine NEGATIVES: Doesn’t address frequency of attacks or impact on quality of life If not taken at onset, less effective Acute therapies not always effective Undesirable side effects Frequent use can cause rebound headache

Acute Therapy : 

Acute Therapy Start Rx at the earliest Exception – sc Sumatriptan act best after onset of headache Oral drugs less effective once attack begin – vomiting, Dec GI motility & absorption Sleep in a dark, quiet room with ice pack over head NSAIDS+ Caffeine + Metoclopromide 10 mg

Triptans : 

Triptans Selective 5HT agonists Benefit headache & associated symptoms Triptans ineffective in migraine with aura till aura is over & headache begins After one Triptan, another Triptan or ergot is CI for 24 hours SE – Flushing, neck / chest pressure

Mechanism of action of Triptans : 

Mechanism of action of Triptans Stimulation of the 5-HT1B/D receptors. 5-HT1B receptor stimulation cause cranial vaso-constriction Selective for cerebral blood vessels since peripheral vasoconstriction is mediated by 5-HT2 receptors. 5-HT1D receptors on 1st & 2nd order trigeminal neurons decrease release of neuropeptides mediating vaso-dilation & activity of pain-signalling neurons

Triptans contraindications : 

Triptans contraindications CAD HTN PVD Hemiplegic or Basilar migraine Avoid in those on Ergots, SSRI & TCA Pregnancy, Lactation Should not use more than 2 days a week to decrease possible rebound headaches.

7 Triptans : 

7 Triptans Sumatriptan Rizatriptan Naraitriptan Zolmitriptan Eletriptan Almotriptan – fast acting Frovatriptan – slow acting & lowest efficacy

Sumatriptan : 

Sumatriptan 6 mg sc 25 to 100 mg orally 20 mg nasal spray

Oral Sumatriptan for a/c migraine : 

Oral Sumatriptan for a/c migraine 25 trials - 16,200 participants Placebo comparisons -16 trials - showed that sumatriptan in doses of 100 mg (14 trials), 50 mg (5 trials), and 25 mg (3 trials) provided significantly better pain relief at 2 hours. Adverse events were more common with sumatriptan 100 mg than with placebo Cochrane Review - 2011

Oral sumatriptan - Authors’ conclusions : 

Oral sumatriptan - Authors’ conclusions Oral sumatriptan is an effective drug for treatment of a single acute attack of migraine. It is well tolerated, though minor adverse events were not uncommon in included trials. Other triptans - similar in efficacy & adverse events. Among non-triptan drugs, ergotamine + caffeine was significantly less effective than sumatriptan, and other drugs have been insufficiently studied Cochrane Review - 2011

Rizatriptan : 

Rizatriptan Fast acting 10 mg PO 10 mg dissolvable wafer Rizact

Naraitriptan : 

Naraitriptan Slow acting & lowest efficacy Better tolerability Study – Useful in Menstrual migraine 1 or 2.5 mg PO Naraitrex

Zolmitriptan : 

Zolmitriptan 2.5 mg PO Dispersible tablets also – 2.5 mg 5 mg nasal spray

Caffeine : 

Caffeine Aids absorption Induce vasoconstriction Dec firing of serotonergic brainstem neurons Not to be taken > 2 times / week – Increase headache frequency Caffeine addiction/withdrawal headache may occur

Ergots : 

Ergots Vasoconstrictor 5HT agonist – similar to triptans But more adverse effects due to binding at non-5HT1 receptors, dopaminergic & adrenergic receptors. Dose – 2 mg immediately – can repeat after 1 hour Rectal or Parenteral better than oral Combine with NSAIDS + Caffeine Slower action than Triptans but lesser recurrence

Ergots… : 

Ergots… Inc nausea – combine with antiemetics Maximum 6 mg / week – otherwise withdrawal headache Caution – HTN, PVD, Prolonged aura or aura with major CNS deficits CI – Pregnancy, CAD, Concurrent use of phenyl propranolamine

Steroids - dexamethasone addition to standard therapy for a/c migraine : 

Steroids - dexamethasone addition to standard therapy for a/c migraine 7 RCTs (n=742) Dexamethasone vs. placebo (both + standard therapy): Dexa group was less likely to experience recurrent headache within 24 to 72 hours. Authors' conclusions - moderately effective at preventing headache recurrence when used in addition to standard treatment of a/c migraine. Side effects are mild and transient Cochrane - 2008

Intranasal Lidocaine : 

Intranasal Lidocaine Absorption of oral drugs inadequate in acute migraine Intranasal Lidocaine provided rapid and effective relief of pain in ~ 55% of patients Most of the effect occurred within 5 minutes, & nausea and photophobia were similarly relieved. BUT - 42% had relapse - comparable with sumatriptan The onset of relapse with Lidocaine, however, was within 1 hour.

Normobaric & hyperbaric oxygen for migraine : 

Normobaric & hyperbaric oxygen for migraine 9 small trials involving 201 participants Trials suggest that HBOT is effective in relieving migraine headaches compared to sham therapy. No evidence that HBOT could prevent migraine episodes, reduce nausea & vomiting or reduce use of rescue medication. No serious adverse effects of HBOT or NBOT were reported. Cochrane review 2009

NBOT & HBOT - Authors’ conclusions : 

NBOT & HBOT - Authors’ conclusions There was some evidence that HBOT was effective in a/c migraine in an unselected group Given the cost and poor availability of HBOT, more research should be done on patients unresponsive to standard therapy. NBOT is cheap, safe and easy to apply, so will probably continue to be used despite limited evidence. Cochrane review 2009

Other drugs in acute therapy : 

Other drugs in acute therapy Narcotics – nasal Butorphanol Isometheptene

Acute treatment of migraine. Breaking the paradigm of monotherapy : 

Acute treatment of migraine. Breaking the paradigm of monotherapy Evidences support use combination of drugs acting on different mechanisms in acute migraine Whom to use - patients not achieving pain-free status in 2 hours or not getting sustained pain relief for 24 hours in 5 previous migraine attacks What to use - combination of NSAID plus a Triptan or a gastro kinetic drug such as 20 mg Metoclopromide or 30 mg domperidone BMC Neurology

Slide 89: 

Preventive Therapy Patients qualify for preventive treatment if: Recurring migraine significantly interferes with daily routine Frequent attacks (2 or more migraines per month with disability totaling 3 or more days) Acute medications are used more than 2 times per week Acute medications are contraindicated, not tolerated, or ineffective

Preventive Therapy: Is it needed ? : 

Preventive Therapy: Is it needed ? Migraine is a chronic and progressive disease Delay in initiating appropriate treatment may hasten the development of central sensitization within and between attacks. This can lead to progression from episodic migraine to chronic migraine in 5% patients. JAOA • Supplement 2 • Vol 105 • No 4 • April 2005 - Advances in Migraine Treatment - George R. Nissan et. al

Preventive Therapy - components : 

Preventive Therapy - components Trigger factor modification Non pharmacologic measures Pharmacologic measures

Slide 92: 

Migraine Triggers Migraine triggers present in up to 85% of patients Average number of triggers is 3/patient Weather changes, smoke, bright lights, certain smells) Emotions (stress, anxiety, crying) Change in sleep pattern Diet - cheese, redwine, chocolate, nitrates Skipping meals Estrogen (menstrual cycle)

Trigger factor modification : 

Trigger factor modification Identify and then avoid trigger factors such as Stop smoking Decrease alcohol Avoid irregular sleep pattern Avoid prolonged fasts Avoid irregular sleep Anti glare measures Avoid strong perfumes Acute changes in stress levels Avoid certain foods (chocolates, cheese)

Avoid drugs causing headaches : 

Avoid drugs causing headaches Reserpine Nifedipine Nitrates Theophylline Estrogens, OCP Ovulation inducers Indomethacin Steroid withdrawal

Slide 95: 

Behavioral Modification

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Classes of Agents Used for Preventive Therapy Calcium channel blockers Flunarizine Verapamil Beta-blockers Propranolol and Timolol Metoprolol Tricyclic antidepressants (TCA) Amitriptyline Nortriptyline AEDs (also called "Neurostabilizers") Divalproex sodium/Valproate semisodium Topiramate Serotonin Antagonists Pizotifen Methysergide Serotonergic agents Time-released dihydroergotamine

Calcium channel antagonists : 

Calcium channel antagonists Flunarizine Indicated in classical & common migraine. Dose :10 mg/d. In patients weighing <40 kg & elderly : 5 mg/d. SE – somnolence, fatigue, and weight gain Adverse reactions are usually transient.

Flunarizine -Mechanism of Action : 

Flunarizine -Mechanism of Action Ca++ entry blocker : Via Ca channels in cell membrane No effect on voltage operated Ca channels in heart. Protects RBCs against Ca overload Protects vascular smooth muscle from Ca overload Prevents vascular constriction Protects brain cells against Ca overload & subsequent brain cell damage.

Slide 99: 

Within first four weeks migraine frequency reduces Decrease in migraine frequency develops gradually over the first three months of therapy. Patients continue to experience relief for several months after 6-9 months of treatment. Flunarizine has better safety profile than Propranolol Flunarizine - role in migraine prophylaxis

Beta blockers : 

Beta blockers Propranolol – 80 to 240 mg / day - LA better Timolol, Nadolol, Atenolol, Metoprolol

Propranolol for migraine prophylaxis Cochrane Review - 2009 : 

Propranolol for migraine prophylaxis Cochrane Review - 2009 58 trials (n= 5072) met inclusion criteria. Most studies were of poor quality 26 placebo-controlled trials showed clear short-term effects of Propranolol over placebo. 47 comparisons with calcium antagonists, other beta-blockers, and a variety of other drugs did not yield any clear-cut differences. Cochrane Review - 2009

Propranolol - Author’s conclusions : 

Propranolol - Author’s conclusions Although many trials have shortcomings, there is clear evidence that Propranolol is more effective than placebo in short-term treatment of migraine. Evidence on long-term effects is lacking. Propranolol seems to be as effective and safe as other drugs used for migraine prophylaxis. Cochrane Review - 2009

Tricyclic antidepressants : 

Tricyclic antidepressants Independent of antidepressant action Amitryptiline – 10 to 150 mg HS Imipramine Desimipramine Nortryptyline Anticholinergic side effects

Anticonvulsants for migraine prophylaxis : 

Anticonvulsants for migraine prophylaxis Divalproex sodium – 500 to 1750 mg/day Sodium Valproate Topiramate – 70 to 200 mg / day Gabapentin – 600 to 2400 mg / day

Topiramate : 

Topiramate FDA approval in 2004 Trials – reduce attacks by 50% & well tolerated. Start at 25 mg, increase by 25 mg/ week to 100-200 mg SE – usually transient and mild Paresthesias Weight loss Acute glaucoma - rare Renal colic may exacerbate Category C drug in pregnancy Can decrease OCP efficacy

Anticonvulsants for migraine prophylaxis (Cochrane Review 2009) : 

Anticonvulsants for migraine prophylaxis (Cochrane Review 2009) 23 papers met inclusion criteria - 2927 patients 10 trials (n = 902) shows that AEDs reduce migraine frequency by 1.3 attacks/ 28 days 13 trials (n = 1773) show that AEDs more than doubles the number of patients for whom migraine frequency is reduced by 50% or more Cochrane Review 2009

AEDs - authors’ conclusions : 

AEDs - authors’ conclusions AEDs appear to be effective & well tolerated. Variation among individual agents, but insufficient data. Robust trials are available only for Na valproate, Divalproex sodium and topiramate Acetazolamide, Clonazepam, Lamotrigine, Vigabatrin were not superior to placebo. Gabapentin needs further evaluation. Cochrane Review 2009

Serotonergic agents : 

Serotonergic agents Methysergide Block peripheral 5 HT actions All types of vascular headache Only for intractable – max 6 months Cyproheptadine Peripheral Serotonin antagonist More effective in children

Slide 109: 

Maintain headache diaries – can document effect or lack of it Formal disability scales can be used MIDAS (Migraine Disability Assessment Scale) can quantify the disability

MIDAS (Migraine Disability Assessment Scale) : 

MIDAS (Migraine Disability Assessment Scale) About headaches in last 3 months. 1 How many days did you miss work due to headaches? 2 How many days productivity at work was reduced due to headaches? (Do not include days counted in 1) 3 How many days you did not do household work due to headaches? 4 How many days was your productivity in household work reduced by half or more due to headaches? (Do not include days counted in 3) 5 On how many days in the last 3 months did you miss family, social or leisure activities due to headaches? TOTAL days -

Grading system for MIDAS Questionnaire: : 

Grading system for MIDAS Questionnaire: Grade Definition Score I - Little or no disability 0–5 II - Mild disability 6–10 III - Moderate disability 11–20 IV - Severe disability 21+ A On how many days in the last 3 months did you have a headache? (If a headache lasted more than 1 day, count each day) B On a scale of 0–10, on average how painful were these headaches? (Where 0 = no pain at all, and 10 = pain as bad as it can be)

Recent Advances : 

Recent Advances

CGRP antagonists : 

CGRP antagonists Calcitonin gene-related peptide - CGRP Important pathophysiological role in migraine Potent vasodilator released from trigeminal -vascular system during migraine Levels raised during & immediately after migraine attack No direct vasoconstrictor activity – so safe in CAD N Engl J Med 2004;350:1104-10.

CGRP antagonists in trial : 

CGRP antagonists in trial BIBN4096BS effective in treating acute migraine – 2.5 mg Olcegepant – IV Telcagepant – oral 300 mg

NXN 188 : 

NXN 188 Under study for acute migraine Dual action 5HT1 stimulator Neuronal Nitric oxide synthase enzyme inhibitor

Single pulse transcranial magnetic stimulation in acute migraine - sTMS : 

Single pulse transcranial magnetic stimulation in acute migraine - sTMS A device delivers a pulse transcranial magnetic stimulation at the onset of headache or aura Idea is to disrupt cortical spreading depression by application of sTMS at the onset of aura Lipton et al reported promising results in their study

Migraine prophylaxis with oral magnesium : 

Migraine prophylaxis with oral magnesium 81 patients (18-65 years) with migraine received oral trimagnesium dicitrate 600 mg/d for 12 weeks or placebo. In weeks 9-12 attack frequency was reduced by 41.6% in magnesium group and by 15.8% in placebo group compared to baseline (p < 0.05). Adverse events - diarrhea (18.6%) & gastric irritation (4.7%) High-dose oral Mg appears to be effective in migraine prophylaxis Cephalalgia. 1996 Jun;16(4):257-63

Acupuncture for migraine prophylaxis : 

Acupuncture for migraine prophylaxis 22 trials (4419 patients) met inclusion criteria. Acupuncture vs. no prophylaxis - 6 trials After 4 months acupuncture patients had higher response rates and fewer headaches. True acupuncture vs. sham interventions – 14 trials - did not show significant superiority Acupuncture vs. proven prophylactics – 4 trials Acupuncture had slightly better outcomes & fewer adverse effects than prophylactic drugs. (Cochrane Review - Linde K et. al – 2009)

Acupuncture - Authors’ conclusions : 

Acupuncture - Authors’ conclusions There is evidence that acupuncture is better than treatment of a/c migraine only or to routine care. Available studies suggest that acupuncture is at least as effective as, or possibly more effective than, prophylactic drugs, & has fewer adverse effects. Acupuncture should be considered a treatment option for willing patients (Cochrane Review - Linde K et. al – 2009)

Biofeedback for migraine: : 

Biofeedback for migraine: 55 studies (n=2,229) were included Medium statistically significant effect on headache compared with baseline Follow-up studies (15 studies). Medium-to-large statistically significant effect on headache No significant differences BFB modalities Authors' conclusions - medium short- and long-term effect, reducing pain & psychological symptoms Cochrane meta-analysis - 2007

Cochrane Review & meta-analysis of evidence on migraine & PFO closure : 

Cochrane Review & meta-analysis of evidence on migraine & PFO closure Studies underway to look for effect of PFO closure in preventing Migraine Migraineurs were found to have PCA emboli during attacks Since both Migraine & PFO being common – cause and effect yet to be established

Botulinum toxin type A and c/c migraine : 

Botulinum toxin type A and c/c migraine Botulinum toxin type A injected symmetrically into the glabellar, frontalis, and temporalis muscles. May reduce the local release of nociceptive neuropeptides. Postulated to decrease release of CGRP Also, it is postulated that the nerves may be stimulated by the strong contraction of the corrugator supercilii and the temporalis muscles.

Botulinum toxin A for prophylaxis of episodic migraine - metaanalysis : 

Botulinum toxin A for prophylaxis of episodic migraine - metaanalysis 8 RCTs - n=1,601 No statistically significant benefit Authors' conclusions - Botulinum toxin A was not significantly different from placebo for episodic migraine prophylaxis. Cochrane 2009

Occipital nerve stimulation : 

Occipital nerve stimulation Used in patients with intractable migraine Controlled observations of occipital nerve stimulation in chronic migraine are extremely promising.

Slide 125: 

The future for migraine treatment seems bright as the understanding of the disease is improving and newer & safer treatments are in the offing.

Thank you : 

Thank you