Introduction:
Introduction PLGA is a copolymer of the PLA & PGA . PLA – poly lactic acid PGA- poly glycolic acid. PLGA have been extensively investigated because of their biocompatibility and biodegradability.
Cont….:
Cont…. Nanoparticles act as potential carries for several classes of drugs such as anticancer agents, antihypertensive agents, immunomodulators, and hormones; and macromolecules such as nucleic acids, proteins, peptides, and antibodies.
Applications of PLGA :
Applications of PLGA Gene Delivery Chemotherapeutic Delivery
PLGA controlled Delivery of Doxorubicin for treatment of cancer:
PLGA controlled Delivery of Doxorubicin for treatment of cancer The novel drug delivery system here utilized consists of biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles. These nanoparticles are used as vehicles for the targeted and controlled delivery of doxorubicin, a commonly used and potent chemotherapeutic agent. PLGA nanoparticles provide protection to the therapeutic agent from degradation by physiological conditions, and release the drug in a controlled manner so that its concentration is maintained within therapeutic levels for longer periods of time.
Cont…:
Cont… In addition, these nanoparticles are small enough to circulate through capillaries, cross the highly-permeable vasculature supplying blood to the tumor, and enter tumor cells through endocytosis or receptor-mediated transport.
Mode of action :
Mode of action The targeted nanoparticles finds the specific cellular target The nanoparticles binds to the surface of the cell If the target is internalized the nanoparticles is carried to the intracellular environment If the target is not internalized the delivery system has been engineered to release the nanoparticles at the surface of the cell allowing for endocytosis to occur .
Slide 8:
THANK UUUU By:- Pramod Rathor