RECENT TRENDS IN PHARMACEUTICAL PACKAGING: RECENT TRENDS IN PHARMACEUTICAL PACKAGING By Prashant Patel Department of pharmaceutical technology Indukaka Ipcowala college of pharmacy Why Packaging development is needed?: Why Packaging development is needed? In India, pharma packaging today occupies a significant portion of the overall drugs market. Earlier , the requirements of pharma packaging focused exclusively on preserving the quality of enclosed medication . Now , they are extended to cover such criteria: prevention of product tampering and counterfeiting assurance of product dispensing accuracy promotion of patient compliance with product dosage schedules. PowerPoint Presentation: Reckitt Benkiser launched the easily portable 'Handy Tube' version of its popular Strepsils line of sore throat lozenges. The new packaging is not only convenient to carry, but at the same time provides adequate humidity protection to the product during its shelf life. stability and shelf life to the drug PowerPoint Presentation: Moov - pain reliever by Paras Pharmaceuticals now bought over by. Reckitt Benckiser. It was earlier available in tubes; but it is now also available as an aerosol spray which is convenient, easy to apply and ideal for people on the move. convenience and compliance of drug use. PowerPoint Presentation: “ The packaging contains coding by which consumers can connect via smart phone to product content in addition to what they can already see on a drug's label, printed packaging and inserts. The manufacturing and packaging contractor sees the technology as a way to give clients' products a leg up on crowded retail shelves” - Catalent Pharma Brand identity Major influences are:: Major influences are: Product trends influencing pack trends Changes and trends in packaging materials Changes in packaging processes Current market scenario: Current market scenario Global pharma packaging industry studies show that by 2011 pharma packaging industry was expected to grow by 5.9 percent per annum and was predicted to reach $34 billion mark within 2011 . While as per a McKinsey report , Indian pharma packaging is expected to reach $50 billion by 2015 . Nano technology, The global market for nano-enabled packaging for blisters was $941 million in 2008 and is expected to grow to $2.10 billion by 2014 . Different trends: Different trends Sustainability Cost effective Robots in primary packaging - ESS Technology and FUNAC system Radio-frequency identification(RFID) Electronic-Enabled Packaging Unit-dose packaging for greater dosage control Packaging against counterfeiting Child-resistant packaging Eco-friendly pharma packaging The Talking Packaging : “Self Talk” Dispensing Caps Sustainability: Sustainability Cost effective: Cost effective Chennai - based company Jumbo Bags who after intensive R&D developed bags with corrugated linings weights capacity- 500 kgs to 2000 kgs . it could be folded when not in use which was not possible while using drums. Price- drum costs Rs 120 to Rs 150. for 30 drums , the total cost would be Rs 3600 . The bag manufactured by Jumbo Bags would cost only Rs 2500 . Robots (and robot-like devices) also increase flexibility of packaging equipment, decrease time consumption , increase output and reduce labor cost . Robots in primary packaging - ESS Technology and FUNAC system: Robots in primary packaging - ESS Technology and FUNAC system Radio-frequency identification(RFID): Radio-frequency identification(RFID) RFID tagging to simplify shipping , receiving , inventory location , and control has been mandated by the Department of Defense , several other retailers , and various hospitals . carry and collect the data needed to track and trace product through the supply chain prevent counterfeiting and diversion coupled with sensors to monitor conditions during shipping and storage and provide alerts if parameters are exceeded . to monitor patient compliance. Tagged blisters record when doses are taken (" Med- ic " electrical compliance monitor , Information Mediary Corp., Ottawa, ON, Canada, www.informationmediary.com ) PowerPoint Presentation: Dual-function tags - RFID with temperature sensing , having cost less than traditional devices for temperature monitoring e.g. integrates a sensor , microchip , battery , and antenna on a paper-thin label. 13.56 MHz ( " TempSens " smart label, KSW- Microtec , Dresden, Germany . This type of smart sensor label–equipped blister package is being used by the National Institutes of Health (Bethesda, MD), for a multiyear study of chronic obstructive pulmonary disease that will involve nearly half a million individual doses of medication. Electronic-Enabled Packaging : Electronic-Enabled Packaging In February 2011, Finnish packaging company Stora Enso unveiled the newest iteration of its adherence control packaging , Pharma DDSi Wireless. This technology is based on conductive ink on a carton board-based blister inlay, which is connected to a cellular module embedded in the package. The removal of pills is tracked and the information can be sent to an electronic database automatically via GSM or GPRS cellular networks. Stora Enso's new Pharma DDSi Wireless packaging leverages cellular networks to track patient adherence data, allowing reminders to be sent by text. PowerPoint Presentation: Catalent's Delpouch Starter Kit packaging system, designed for topical treatments . Delpouch measures the right amount of topical cream or ointment to simplify the application process . Catalent's Media Enhanced Packaging technology , which allows patients to scan a digitally embedded watermark in the packaging with their smartphones to access extra product information, videos or even real-time safety updates . PowerPoint Presentation: Cypak's advanced medication monitoring and report card systems , can record the time and date that a pill was taken based on when it is removed from its blister pack Packaging can now connect with computers using sensor technology . allowing patients to log their feedback on side-effects and treatment efficacy and upload it. Unit-dose packaging for greater dosage control: Unit-dose packaging for greater dosage control Aim:-"With more of a focus on outpatient care and the self-regulation of medicine, there's greater onus on patients to take the right medications in the right amount " A January 2012 study by US-based market research firm Freedonia suggests “unit-dose formats, including vials, ampoules, prefillable syringes and premixed IV solutions, are some of the biggest growth drivers of the aseptic packaging market .” In fact, prefillable syringes are predicted to represent the fastest growing aseptic packaging type, with demand expected to grow 11% each year to $1.1bn . PowerPoint Presentation: Bosch Packaging Technology recently acquired the machinery business of Eisai, a Japan -based leader in filling single doses . Packaging against counterfeiting: Packaging against counterfeiting AS per FDA - counterfeit drugs account for 10% of all medication in the US EU believes between 1% and 3% of medicines latest developments are fluorescent labels , packaging with laser surface authentication , which can be identified through a unique code , and near field communication (NFC) tags . In India for instance, drug companies have been sending their medicines to overseas markets including an obligatory sport barcode on their outermost packaging , started in October 2011 . Child-resistant packaging: Child-resistant packaging Keeping drugs secure from young children while ensuring user-friendliness to seniors is one of the main objectives of pharmaceutical packaging companies . Child-resistant (CR) packaging was introduced in the late 1960s and early 1970s , and is most commonly known as a safety cap on bottles that has to be pushed down before being opened . More advanced CR packaging, such as special blister packs and cardboard packaging , has only been released onto the market in the last decade, and looks set to continue its growth in the future as its popularity increases . PowerPoint Presentation: Packaging company Amcor Flexibles followed suit a few years later and introduced a CR blister pack, the Guardlid , which is compliant to CR / senior friendly (SF) regulations in Europe and the US. PowerPoint Presentation: UK packaging producer Burgopak's sliding CR blister pack can only be opened by applying pressure at two separate points on the packaging. The blister pack and information leaflets are integrated with the outer box, which ensures the product is never separated from its packaging . Burgopak Healthcare & Technology - won the award for the ‘Most Innovative Child Resistant Packaging Design’ at the Pharmapack Paris exhibition on 16th February 2012 . PowerPoint Presentation: In 2006, Stora Enso and Bosch Packaging launched Pharma small hands resistant (SHR) , a re-closable and tear-resistant carton ideal for highly toxic drugs , which TestPak , lnc . started using and producing the same year. Eco-friendly pharma packaging: Eco-friendly pharma packaging Environmental considerations must not lead to any compromise on a package's safety or accessibility . New pharmaceutical packaging concepts are beginning to emerge that address environmental concerns without sacrificing packaging advances made in the last decade. PowerPoint Presentation: In August 2011, Keystone Folding Box Company and Legacy Pharmaceutical Packaging launched their Ecoslide -RX sustainable compliance packaging. The pack is made from 100% recycled material , using unbleached paperboard and a clay-coated surface designed to house blister packaging with a minimum of unsustainable film and foil . The slide package meets all the modern expectations for child-resistance and accessibility for seniors , but doesn't require heat sealing in the manufacturing process, reducing both costs and energy usage . Syreen prefilled syringe design: Syreen prefilled syringe design Environmental awareness is even starting to extend to the syringe market. Syreen syringes replace glass with cyclic olefin polymer (COP) , this material has allowed Cambridge consultant to jettison secondary packaging altogether as the COP design forms its own outer shell. The ability of packed syringes to clip into place also eliminates the need for packing materials like styrofoam and cardboard . Packaging weight reduction - 30% and volume - 50 % , compared to standard packaging. The Talking Packaging : “Self Talk”: The Talking Packaging : “Self Talk ” There are two developments in talking packaging at this moment The “ TalkPack ” from Wipak Walsrode GmbH in Germany, a system , which can be invisibly integrated into any printed image on any packaging material, but needs a special scanning pen a recent development by VTT Technical Research Centre of Finland using tags with NFC (Near Field Communication) based technology connected to NFC-enabled mobile phones to download text, audio or web page product information, which can be played back on their handset . Talk Pack-Wipac: Talk Pack - Wipac A special pen-shaped reader is used to retrieve the stored information and to replay it as audio files and render speech , music or sounds audible and thus the consumer can obtain information on the manufacturer , brand , shelf-life or other information. Talk Pack does not require any RFID or microchips . the dot code is simply printed on top of images and texts using a special varnish. This technology can be used with all printing technologies and package types . NFC tags - VTT Technical Research Centre: NFC tags - VTT Technical Research Centre NFC tags are added to any packaging so a consumer could touch the code on the packaging with their NFC-enabled mobile phone to download text, audio or web page product information , which can be played back on his handset. provided spoken dosage instructions from pharmacy staff, to aid a visually impaired or blind person . Currently, the number of mobile phones with NFC technology is limited but VTT believes that it is a growing market. Dispensing Caps : Dispensing Caps dispensing caps or functional caps - store dry or liquid supplements separately from the water - released by the consumer they form an energy or vitamin drink or sometimes a medicinal drink . everything from pharmaceuticals to nutraceuticals, from anti-aging to anti-oxidants, from vitamins to functional supplements, from male potency to stem cell stimulants, from energy to relaxation and so on can be packed and properly dosed by a dispensed cap . it is generally claimed that pills and capsules have a very short window of absorption Liquid absorption is much higher: around 80-90% . It would more preferred especially when it comes to children and the elderly . PowerPoint Presentation: One of the most basic designs in a patent filed in 2002 by inventor Stephen Carlson and assigned to The Coca-Cola Company . PowerPoint Presentation: A typical dispenser cap includes a space which holds the substance to be dispersed (vitamin, flavour , medicine in powder form, liquid or tablet), which is bounded and sealed on one side by a membrane . A membrane opening device is used, often activated by depression of a flexible diaphragm, which causes the membrane opening device to pierce the membrane, thus enabling mixing of the contents of the dispenser with those of the container to which it is attached . Recent changes and development in Inhalers (MID, pMID, DPI, nebulizers): Recent changes and development in Inhalers (MID, pMID, DPI, nebulizers) H ydrofluoroalkane (HFA) propellant replacing the chlorofluorocarbon ( CFC) due to concerns about the latter’s damaging effect on the ozone layer . The US Food and Drug Administration (FDA) has ruled that no CFC MDIs will be sold in the US after 2008 . As a result of the requirement to use HFA propellants, challenges arose with respect to re-designing formulation, valves, and actuators and conducting clinical trials. The elastomeric components in existing metering valves are generally incompatible with HFA propellants, and some surfactan PowerPoint Presentation: DPI devices are categorized as single-unit dose inhalers in which each dose is loaded into the device before use ( Aerolizer ™ , Novartis ; Handihaler ™ , Boehringer Ingelheim ) multidose reservoir inhalers in which a large supply of drug is pre-loaded into the device ( Turbuhaler ™ or Flexhaler ™ , Astra Zeneca ; Twisthaler ™ , Schering-Plough ) multiunit dose inhalers in which several single doses are individually sealed and discharged each time the device is actuated ( Diskus ™ , GlaxoSmithKline ). PowerPoint Presentation: The Aerolizer uses separate single-dose capsules while the Flexhaler , Diskus , and Twisthaler all have dose indicators. In contrast, pMDIs do not have an independent means by which to monitor the number of doses remaining in the device. In March 2003 , the FDA issued guidelines that recommended manufacturers integrate a dose-counting device into new pMDIs (www.fda.gov/cder/guidance/ 5308FNL.htm). Some pMDIs have now incorporated dose counters ( Ventolin HFA , Flovent HFA , and Symbicort ) without major changes. Aeroneb® Solo nebulizer: Aeroneb ® Solo nebulizer The Aeroneb ® Solo nebulizer is designed to operate in-line with standard ventilator circuits and mechanical ventilators . Operated without changing patient ventilator parameters. R efilled without interrupting ventilation. O perated on its internal rechargeable battery for up to 45 minutes when fully charged. O perates without compressed gas , making it suitable for portable applications Aeroneb Pro: Aeroneb Pro The Aeroneb Pro is a reusable , multi-patient use nebulizer which is suitable for hospital environments where the appropriate sanitization facilities are available . Cost-Effective: Negligible residual volume in medication cup, so minimizes drug waste Multiple patient use Autoclavable at 132ºC - 135ºC (270ºF - 275ºF ) Flexible: Operates in-line with standard ventilator circuits off-vent with an aerosol mask or a mouth piece Accessorized to treat for infant thorugh to adult Aero Chamber plus Flow-Vu -Monaghan Medical Corporation; marketed by Forest Laboratories: Aero Chamber plus Flow-Vu - Monaghan Medical Corporation ; marketed by Forest Laboratories Diskus Inhaler Technique: Diskus Inhaler Technique Device innovators and manufacturers were honored as AANMA’s first innovative technology award at the 15th annual Allergy & Asthma Day Capitol Hill on Thurs., May 10, 2012 . A DISKUS® is a dry-powder inhaler that holds 60 doses . It features a built-in counter , so that you always know how many doses you have left in it. First dry powder inhaler that simplifies asthma care by combining an inhaled corticosteroid with a long-acting bronchodilator in one device .- GlaxoSmithKline References: References Chapter 17,packaging of pharmaceutical dosage forms, Gilbert S. Banker, Christopher T. Rhodes,pg . Dr . John Green, Dr. Erik Gommeren , PHARMACEUTICAL AEROSOLS – ENHANCING THE METERED DOSE INHALER, DuPont Central Research & Development . Shyam Sunder B K, Pharmaceutical packaging - A growing phenomenon, http://www.expresspharmaonline.com/20110131/packagingspecial03.shtml Dvaczek , Tracking Growth Trends, Pharmaceutical & Medical Packaging News, March 2010, Volume 18, No. 3 http :// www.pharmaceutical-technology.com http:// goarticles.com/article/Analysis-of-trends-in-recent-years-pharmaceutical-packaging-carton-cartons-paper-packaging-whit http:// bestinpackaging.com/2012/03/18/developments-in-healthcare-packaging Trends in pharmaceutical packaging, www.sigpacksystems.com References: References http://www.foodproductdesign.com/news/2011/02/top-five-packaging-trends-for-2011.aspx# http://www.freedoniagroup.com/Pharmaceutical-Packaging.html Trends in pharmaceutical packaging, SigPack Systems, www.sigpacksystems.com http://www.ngpharma.eu.com/article/Trends-in-pharmaceutical-packaging/ http://www.pharmtech.com/pharmtech/Packaging+Forum/Packaging-Trends/ArticleStandard/Article/detail/407882 http://www.contractpharma.com/issues/2012-04/view_features/packaging-trends-and-anti-counterfeiting-initiatives/ www.aerogen.com http://www.umkc.edu http://www.boschpackaging.com http://media.amcor.com http://www.ondrugdelivery.com Thank you For your kind Attention !!!!!!!!!: Thank you For your kind Attention !!!!!!!!!