LUNG QUANTITATION and LUNG PERFUSION RADIOPHARMACEUTICAL PARTICLE CALCULATIONS :LUNG QUANTITATION and LUNG PERFUSION RADIOPHARMACEUTICAL PARTICLE CALCULATIONS BY: ALBERTO ARIAS


OBJECTIVES :OBJECTIVES Learn and see example of LUNG QUANTITATION Learn and see example of LUNG PERFUSION RADIOPHARMACEUTICAL PARTICLE CALCULATIONS Be able to do problems pertaining to these two subjects


LUNG QUANTITATION :LUNG QUANTITATION Lung quantitation allows the physician to determine the percentage of perfusion and air circulation occurring in each lung or portion of each lung It is most likely to be used for patients who are to undergo resection for lung cancer


FORMULA for LUNG QUANTITATION :FORMULA for LUNG QUANTITATION % activity in ROI = (counts ROI/ total counts in all ROI’s) X 100 The region of interest can be an entire lung or a lung can be divide into two or three segments


EXAMPLE :EXAMPLE Because of the normal size difference between the left and right lung, the left lung usually receives 45% of perfusion, while the right lung receives 55%. Determine if a patient with 186,011 counts from the left lung and 359,548 counts from the right lung has a normal distribution


EXAMPLE (cont.) :EXAMPLE (cont.) Left lung (186,011/545559) X 100 = 34% Right Lung (359,548/545559) X 100 = 66% Answer = The patient does not have a normal distribution


LUNG PERFUSION RADIOPHARMACEUTICAL PARTICLE CALCULATIONS :LUNG PERFUSION RADIOPHARMACEUTICAL PARTICLE CALCULATIONS In order to assure an adequate distribution of the macroaggregates or microspheres, a patient should receive an adequate number of particles


FORMULAS :FORMULAS Specific concentration = activity/volume Required volume = activity desired/ specific concentration Particle concentration = total particles in kit/ mL added to kit


FORMULAS (cont.) :FORMULAS (cont.) Particles per dose (use proportion) (particles/1mL) = (particles in patient dose/ mL of patient dose)


EXAMPLE (particles) :EXAMPLE (particles) An MAA kit produced by company XYZ contains an average of 4,000,000 particles. If the kit is reconstituted with 5.0 ml, what is particle concentration. ans. = (4,000,000 particles/5.0 ml) = 800,000 particles/ml


QUESTIONS :QUESTIONS A protocol recommends an MAA kit be reconstituted with 50 mCi Tc 99m pertechnetate in 5 mL. What will be the particle concentration if a kit contains an average of 14 million particles? Ans. = 2,800,000 particles/ml The MAA kit from Company XIX contain an average of 8,000,000 particles. If a kit is prepared with 6 ml of eluate what is the particle concentration? Ans. = 133,000 particles/ml


QUESTIONS (cont.) :QUESTIONS (cont.) 3) An MAA kit has a concentration of 800,000 particles/ml. How many particles will be administered in a .3 ml dose? ANS. = 240,000 particles 4) Calculate the percent perfusion to each lung using the following data. right lung = 319,203 counts; left lung = 515,977 counts ANS. = right lung = 38%, left lung = 62% 5) Determine the percent perfusion to each lung. right lung = 184,537 counts; left lung = 336,246 counts ANS. = right lung = 35%, left lung = 65%


REFERENCES :REFERENCES PRACTICAL MATHEMATICS IN NUCLEAR MEDICINE, Patricia Wells, MAE, CNMT, 1999