logging in or signing up Peptic Ulcer Disease pattersonby Download Post to : URL : Related Presentations : Let's Connect Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 11893 Category: Education License: All Rights Reserved Like it (5) Dislike it (0) Added: October 12, 2008 This Presentation is Public Favorites: 3 Presentation Description No description available. Comments Posting comment... By: rmyylijing (7 month(s) ago) great Saving..... Post Reply Close Saving..... Edit Comment Close By: alsaree335 (34 month(s) ago) thanks, I want to download the presentation,please My e-mail:firstname.lastname@example.org Saving..... Post Reply Close Saving..... Edit Comment Close By: ellie0010 (39 month(s) ago) thanks for this info! its just like a morning sickness treatment.. http://www.morningsicknessfix.com/morning-sickness-treatment/ Saving..... Post Reply Close Saving..... Edit Comment Close By: isabel84 (41 month(s) ago) good one Saving..... Post Reply Close Saving..... Edit Comment Close By: kumarnkp (41 month(s) ago) sir i want to download this presentation please allow me Saving..... Post Reply Close Saving..... Edit Comment Close loading.... See all Premium member Presentation Transcript Peptic Ulcer Disease: Peptic Ulcer Disease Brooke Y. Patterson, PharmD, BCPS NU 7080: Advanced Pharmacology Research College of NursingEpidemiology: Approximately 10% of Americans develop PUD in their lifetime Ulcer-related physician visits have doubled since 1960 Aging population Increased use of NSAIDs EpidemiologyPathophysiology: Duodenal ulcer H. pylori infection (95%) NSAIDS Gastric ulcer NSAIDS H. pylori PathophysiologyClinical Presentation: Duodenal Ulcer Epigastric pain Possibly worse at night Occurs 1-3 hours postprandial Other symptoms: heartburn, belching, bloated feeling, nausea Gastric ulcer Epigastric pain Made worse by eating Clinical PresentationDiagnosis-H. pylori: Breath Tests and Stool antigen tests Urea breath test 95-100% specificity In-office test (breath) Urea Blood Test Less specific Serologic tests Not reliable—persisting antibodies Endoscopy Culture of organism to determine antibiotic therapy Diagnosis-H. pyloriGoals of Therapy: Eliminate causative agent Eliminate H. pylori Discontinue NSAID use Heal gastric erosions Prevent gastric erosions Goals of TherapyTreatment of H. Pylori: ACG guidelines recommend PPI plus at least 2 antibiotics Duration of therapy is 7-14 days 14 days preferred Follow-up testing for eradication High-risk patients Urea breath tests or stool antigen tests At least 4 weeks post-therapy Treatment of H. PyloriTreatment of NSAID-Induced Ulcers: Risk factor modification Discontinue NSAID PPIs Drug of choice Treatment of NSAID-Induced UlcersTreatment of NSAID-Induced Ulcers: Risk factor modification Discontinue NSAID PPIs Drug of choice Treatment of NSAID-Induced UlcersSlide10: Drink no longer water, but use a little wine for thy stomach's sake. -Timothy 1:23 You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.