Doxorubicin & Danorubicin :
Doxorubicin & Danorubicin Side Effects:
Cardiomyopathy
Myelosuppression
Leukopenia (2nd week of therapy)
Thrombocytopenia
Anemia
Stomatitis
GI disturbance
alopecia
Side Effect: Cardiomyopathy :
Side Effect: Cardiomyopathy Dose related, often irreversible
Prior mediastinal radiation/tx with cyclophosphamide
?Troponin T = injury to myocardial cells
Previous anthracycline antibiotic treatment may enhance myocardial depressant effects of anesthetic drugs, even with normal resting cardiac function.
LV function impaired up to 3 years after dc doxorubicin
Acute LV failure during GA 2 months after doxorubicin treatment
CHF:
<3% with cumulative dose <400 mg/m2
18% with cumulative dose @ 700 mg/m
Cardiomyopathy :
Cardiomyopathy