ACC&D Workshop

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Our Mission: To expedite the successful introduction of methods to non-surgically sterilize dogs and cats and to support the distribution and promotion of these products to humanely control cat and dog populations worldwide.

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3 minute spay Pediatric s/n 15K per year TNR

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What we’re working toward: Safe and effective (animals, humans, environment) Permanent (poss. long-term?) One treatment (most likely an injection) Documented effects on health and behavior Affordable

Brief History : 

Brief History Research began in earnest in the 1970’s Research stimulated by development of “the pill” Various approaches studied, but did not progress or moved forward slowly

What’s Out There? : 

What’s Out There? Contraception Azagly-Nafarelin/Gonazon® Deselorin/Suprelorin® Canine Gonadotropin Releasing Factor Immunotherapeutic Sterilization VCD/ChemSpay™ Zinc Gluconate/Neutersol®/Esterilsol™

Suprelorin® and Gonazon® : 

Suprelorin® and Gonazon® Delivered by implant (micro-chip size) Approved in Australia, New Zealand, EU for 1 yr contraception in male dogs and female dogs respectively (female version not introduced). Technology contracepts female dogs and male/female cats as well (3 yr duration in queens) 3 year duration in cats ?

Canine Gonadotropin Releasing Factor Immunotherapeutic : 

Canine Gonadotropin Releasing Factor Immunotherapeutic First immunocontraceptive vaccine conditionally approved in U.S. Pfizer For treatment of benign prostatic hyperplasia (BPH) in male dogs Will cause contraception (~6 mos), though not labeled for this use

ChemSpay™ : 

ChemSpay™ Very early stage work with chemical sterilant for females. Works in mice; hope to formulate for cats and dogs.

Gonacon™USDA/APHIS Center for Veterinary Medicine : 

Gonacon™USDA/APHIS Center for Veterinary Medicine Injectable contraceptive under regulatory review for use in cervids (deer family) Study shows over 3 year effect in (some) cats Study underway in dogs. Refining formulation to improve safety

Neutersol®/Esterilsol™ : 

Neutersol®/Esterilsol™ Intra-testicular injection First permanent non-surgical sterilant to receive regulatory approval FDA-approved for male dogs 3-10 months old. Not current plans for U.S. availability Used effectively off-label in 10,000 adult dogs in Mexico study. Introduced in MX in ‘08 with plans for expansion

What’s the Hold-Up? : 

What’s the Hold-Up? Economics Drug development costly and risky Demand from low-income sector of less interest to pharmaceutical companies Culture Lack of consumer knowledge Resistance to change in veterinary community Science Under-funded researchers, working in isolation Lack of funding for basic repro research

What we’re doing : 

What we’re doing

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Partnership with Found Animals $25M Prize and $50M in Grants

What we’re doing : 

What we’re doing Economics Drug development costly and risky Demand from low-income sector of less interest to pharmaceutical companies Culture Lack of consumer knowledge Resistance to change in veterinary community Science Under-funded researchers, working in isolation Lack of funding for basic repro research

Understanding Veterinary Perspectives : 

Understanding Veterinary Perspectives Surveyed: 200 private practice vets (late 2007) 240 Shelter vets(2008) For new products to be successful, will need to develop more support from vets.

Vet Study Key Findings : 

Vet Study Key Findings 94/96% Vets agree unplanned litters contribute to unwanted pets 6 in 10 shelter vets – agree a need for non surgical sterilants 6 in 10 private practice vets – the opposite. Concept: 3 year cat (m/f)  contraceptive – one treatment/suppresses hormones 52% of vets would recommend Only 30% of shelter vets would recommend

Reaching out to Veterinarians : 

Reaching out to Veterinarians Vets as Directors and Advisors Support from AVMA, Association of Shelter Vets, Cornell Vet School, others Reaching out to vets through publications, conferences

What we’re doing : 

What we’re doing Economics Drug development costly and risky Demand from low-income sector of less interest to pharmaceutical companies Culture Lack of consumer knowledge Resistance to change in veterinary community Science Under-funded researchers, working in isolation Lack of funding for basic repro research

Networking Experts : 

Networking Experts ACC&D Scientific Advisors identify, assess, and advise on existing and novel approaches to contraception

What we’re doing : 

What we’re doing Economics Drug development costly and risky Demand from low-income sector of less interest to pharmaceutical companies Culture Lack of consumer knowledge Resistance to change in veterinary community Science Under-funded researchers, working in isolation Lack of funding for basic repro research

Engaging Stakeholders : 

Engaging Stakeholders On our Board Andrew Rowan, Ph.D., HSUS Steve Zawistowski, Ph.D., ASPCA Bill Torgerson, DVM, American Humane Betsy Saul, Petfinder.com David Gies, Animal Assistance Foundation Linda Rhodes, DVM, Ph.D, AlcheraBio Bob Weedon, DVM, MPH Joyce Briggs, President ACC&D

What we’re doing : 

What we’re doing Economics Drug development costly and risky Demand from low-income sector of less interest to pharmaceutical companies Culture Lack of consumer knowledge Resistance to change in veterinary community Science Under-funded researchers, working in isolation Lack of funding for basic repro research

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Organizational Partners Program

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Pre-written articles, blurbs, descriptions Access to Directors, Advisors and Staff for interviews

Incentives (a.k.a. PRIZES!) : 

Incentives (a.k.a. PRIZES!) Submit your Letter and logo by Dec. 12 for a chance to win $250 voucher toward registration at 2009 animal welfare or veterinary conference $250 Gift Card to Petco or PetSmart $100 Gift Card to Petco or PetSmart

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Private Practice Subsidized $106 Million/yr. @ $50 Reduce to $25 tosave $53 million/Yr. $10M: Where will it help the most?

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“ We must become the change we want to see in the world.” -Mohandas Gandhi