Effervescent tablets

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Presentation Transcript

Effervescent tablets : 

Effervescent tablets NRV SAGAR M.pharmacy

Effervescent tablets : 

Effervescent tablets As per revised definition proposed to US FDA, Effervescent tablet is a tablet intended to be dissolved or dispersed in water before administration. Effervescent tablets are uncoated tablets that generally contain acid substances and carbonates or bicarbonates and which react rapidly in the presence of water by releasing carbon dioxide. They are intended to be dissolved or dispersed in water before use.


INTRODUCTION Active Ingredients 1.Drugs difficult to digest or disruptive to the stomach as calcium carbonate tablets 2.pH-sensitive drugs such as amino acids and antibiotics 3. Drugs requiring a large dose

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Effervescent delivery can be highly beneficial in the following treatments: • Arthritis, inflammation and pain management • Ulcers and gastrointestinal • Allergies • Osteoporosis

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Drugs and drug compositions used as effervescent products • Acetylsalicylic acid (Aspirin) • Paracetamol (Acetaminophen) • Ibuprofen • Antacid preparations • Ascorbic acid and other Vitamins • Calcium • Acetylcysteine, a mycolytic agent used as an antidote for paracetamol overdosage. • Activated charcoal preparations used in the management of theophylline poisoning

Advantages Of Effervescent Tablets : 

Advantages Of Effervescent Tablets 1.Fast onset of action 2.No need to swallow tablets 3.Good stomach and intestinal tolerance 4.More portability 5.Improved palatability 6. Superior stability 7. More consistent response 8. Incorporation of large amounts of active ingredients 9. Accurate dosing 10. Improved therapeutic effect

Preparation of Effervescent tablets : 

Preparation of Effervescent tablets RAW MATERIALS The effervescent tablet mainly consists of three components: • Active ingredient; • Acid source; • Alkaline compound, constituted by a carbonate or bicarbonate

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Acid Sources Three main acid sources are food acids (naturally occurring), acid anhydrides and acid salts. Food acids 1] Citric acid 2] Tartaric acid 3] Ascorbic acid 4] Fumaric acid 5] Malic acid 6] Adipic and succinic acids 7] Acetyl salicylic acid

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Acid Anhydrides Citric anhydride and succinic anhydride Glutamic acid Acid Salts 1] Sodium dihydrogen phospate (monosodium phospate) 2] Disodium dihydrogen pyrophospate (sodium acid pyrophospate) 3] Acid citrate salts 4] Amino acid hydrochlorides 5] Sodium acid sulphite

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Carbonate Sources 1] Sodium bicarbonate 2] Sodium carbonate 3] Potassium bicarbonate and potassium carbonate 4] Sodium sesquicarbonate 5] Sodium glycine carbonate 6] l-lysine carbonate 7] Arginine carbonate 8] Amorphous calcium carbonate 9] Calcium carbonate

Formulation Ingredients : 

Formulation Ingredients 1. Diluents : lactose, mannitol, sorbitol or mixtures thereof and spray-dried lactose 2. Binders : Polyvinyl pyrolidone, Maltilol was also found to be a suitable binder for vitamin C 3, Disintegrants : Dextrose and / or sucrose 4 .Lubricants : factors need consideration solubility and disintegration 5 .Glidants 6 .Antiadherants : polytetrafluoroethylene, polyurethane, 7 .Sweeteners : sucrose, lactose, xylitol, D-glucose, sorbitol or mannitol 8 .Flavors : orange, lemon, pineapple 9 .Colors carotenoids and chlorophyll 10. Surfactants 11 .Antifoaming Agents : dimethyl siloxane


MANUFACTURING Methods For Manufacturing Environmental Conditions Wet Granulation Method TWO-STEP GRANULATION METHOD ONE STEP GRANULATION METHOD Using water Dry Granulation Methods SLUGGING DIRECT COMPRESSION Granulation By Heating TWO-STEP PROCESS ONE- STEP PROCESS Tabletting Of Effervescent Granules


EVALUATION Evaluation parameters for effervescent tablets. •Disintegration Time/Effervescent Time •Dissolution Time •Weight Variation •Content Uniformity Other parameters considered by various scientists include • Crushing Strength/Hardness • Friability • Water content & Moisture Uptake Studies • Carbon dioxide content • pH of the solution • Organoleptic properties

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The physical and chemical properties of the effervescent tablets need special consideration during the evaluation. Physical Properties Disintegration Time/Effervescent Time Dissolution Study Hardness And Friability Tablet Weight Water Content Determination of water content Carbon dioxide Content

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Chemical Properties In-Process Quality Control • Tablet weight • Weight variation • Thickness • Crushing strength • Disintegration • Appearance of the tablet • Friability • pH of solution Stability Packaging materials Filling Packaging Problems

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