9-Ion Exchange.ppt1

Views:
 
Category: Education
     
 

Presentation Description

No description available.

Comments

Presentation Transcript

PowerPoint Presentation:

PREPARED BY : Nitin Baban Bhandurge Pharmaceutics Dept. GUIDED BY : Prof. Shilpa P. Chaudhari ION EXCHANGE RESIN

PowerPoint Presentation:

Introduction Classification Properties Applications Recent advances Future growth References Conclusion CONTENTS

PowerPoint Presentation:

ION EXCHANGE Ion exchange is an adsorption phenomenon where the mechanism of adsorption is electrostatic. Electrostatic forces hold ions to charged functional groups on the surface of the ion exchange resin. The adsorbed ions replace ions that are on the resin surface on a 1:1 charge basis.

PowerPoint Presentation:

ION EXCHANGE RESIN

PowerPoint Presentation:

HOW RESINS EXCHANGE THEIR ION

PowerPoint Presentation:

ION EXCHANGERS (TYPES) Natural: Proteins, Soils, Lignin, Coal, Metal oxides , Aluminosilicates ( zeolites ) (NaOAl 2 O 3 . 4SiO 2 ). Synthetic zeolite gels and most common -polymeric resins ( macroreticular , large pores).

CLASSIFICATION OF ION EXCHANGE RESIN:

CLASSIFICATION OF ION EXCHANGE RESIN

PowerPoint Presentation:

These resins are generally manufactured by polymerizing neutral organic molecules such as sytrene (to form polystrene ) and then cross-linked with divinyl benzene (DVB). Functional groups are then added according to the intended use. Polymeric resins are made in 3-D networks by cross-linking hydrocarbon chains. The resulting resin is insoluble, inert and relatively rigid. Ionic functional groups are attached to this framework. PREPARATION OF ION EXCHANGE RESIN

PowerPoint Presentation:

POLYMERIZATION

PowerPoint Presentation:

Sl. Resin type Chemical constitution Usual form 1. Strongly acidic cation exchanger Sulfonic acid groups attached to a system and divinyl benzene copolymer R-SO3-H+ 2. Weakly acidic cation exchanger Carboxylic acid groups attached to an acrylic and divinyl benzene copolymers R-COO-Na+ 3. Strongly basic anion exchanger Quaternary ammonium groups attached to a styrene and divinylbenzene copolymer [φ-CH2N-(CH3)3+]Cl- 4. Weakly basic anion exchanger Polyalkylamine groups attached to a styrene and divinyl benzene copolymer [φ-NH-(R)] Cl - CHEMICAL CONSTITUENTS FOR IER

PROPERTIES OF ION EXCHANGE FOR RESIN:

PROPERTIES OF ION EXCHANGE FOR RESIN 1) Particle size 2) Porosity 3) Cross linking agents 4) Exchange capacity 5) Acid base strength 6) PH 7) Selectivity of resin for counter ion 8) Mixing time 9) Strength & Stiffness 10) Gelation & stiffness 11) Adhesive properties

PowerPoint Presentation:

12) Fatigue Resistance 13) Osmosis 14) Micro-Cracking 15) Release Agents 16) Internal Mould Release Agent (IMR) 17) External Mould Release Agent 18) Water Ingress PROPERTIES OF ION EXCHANGE FOR RESIN

PowerPoint Presentation:

Exchange Capacity of Weak Acid Cation and Weak Base Anion Resins as a Function of solution pH

APPLICATIONS OF ION EXCHANGE RESINS :

APPLICATIONS OF ION EXCHANGE RESINS Taste masking: Disintegrant./ Superdisintegrant. Improved Dissolution & Powder processing aid. Drug Stabilization. Complexation with ion exchange resins. Sustained Release.

PowerPoint Presentation:

DRUG DELIVERY APPLICATIONS a) Oral modified release formulations. b) Parentaral drug delivery. c) Ophthalmic drug delivery. d) Nasal drug delivery. e) Iontophoretically assisted transdermal drug . delivery system. f) Site specific drug delivery system.

THERAPEUTIC APPLICATIONS. :

THERAPEUTIC APPLICATIONS. Applications in Hyperacidity In ulcer. Na &K supplement Depletion Treatment Nephrotic Treatment pancreatic and cardiac edema . Treatment of Hyperglycemic Treatment Cholestyramine Treatment of hyperkalemia

MISCELLANEOUS:

MISCELLANEOUS Adsorption and recovery of Rifamycin . Preparation of stable coating composition. Removal of metal oxides and hydroxides Process of seperating glucose and mannose withCA /NH4- exchanged ion exchange resin. AMBERCHROM tm Chromatographic Resins. It use as flavored in pharmaceutical industry. Recovery of natural products.

PowerPoint Presentation:

Far more resin is used for water purification than for any other purpose. It is therefore appropriate to discuss water treatment examples when outlining the application of the principles of ion exchange technology. Industrial ion exchange units are produced in sizes ranging from a few liters up to vessels holding several tones of resin. Service runs between regenerations usually range from 12 to 48 hours. The two major types of treatment applied to water are water softening - the replacement of 'hard’ ions such as Ca2+ and Mg2+ by Na+ - and demineralization - the complete removal of dissolved minerals . USE OF ION EXCHANGE RESINSIN WATER TREATMENT

PowerPoint Presentation:

USE OF IER IN WATER & WASTEWATER Ca, Mg (hardness removal) exchange with Na or H . Fe, Mn removal from groundwater . Recovery of valuable waste products Ag, Au, U Demineralization (exchange all cations for H all anions for OH ) Removal of NO 3 , NH 4 , PO 4 (nutrient removal ).

PowerPoint Presentation:

REGENERATION Spent or exhausted columns must be regenerated because of the cost of the resin would make one-time use prohibitive. Since ion exchange is a very reversible process regeneration can be accomplished by manipulation of solution composition.

ION EXCHANGE PROCESS EQUIPMENT AND OPERATION:

ION EXCHANGE PROCESS EQUIPMENT AND OPERATION Most industrial applications of ion exchange use fixed-bed column systems, the basic component of which is the resin column. The column design must: Contain and support the ion exchange resin Uniformly distribute the service and regeneration flow through the resin bed Provide space to fluidize the resin during backwash Include the piping, valves, and instruments needed to regulate flow of feed, regenerant . and backwash solutions

EVALUATION OF DRUG RESINATES:

EVALUATION OF DRUG RESINATES The resinate preparation are evaluation include following methods, 1. In-vitro tests 2. In vivo tests 3. Correlation of in vitro-in vivo release pattern of drug resinates 4. Evaluation of polymer drug-salt complexes. 5. Evaluation of Taste masking Effect

RECENT DEVELOPMENTS:

RECENT DEVELOPMENTS Loading of poorly water-soluble drugs Polymorphism Sustained release

ROLE OF ION EXCHANGE RESINS IN FUTURE GROWTH :

ROLE OF ION EXCHANGE RESINS IN FUTURE GROWTH Ion exchange resins play a key role in four distinct mega-trends: Making more drinking water accessible to mankind Decontaminating surface, ground or wastewater Making the industrial mining of metals like copper, nickel, gold, silver and uranium both more efficient and environmentally friendly by means of a new resin-in-pulp technology Making it possible to produce biodiesel with greater resource efficiency

REFERENCES:

REFERENCES http://en.wikepedia.org/wiki/resin. Ion Exchange Resins Application By Franscois De Dardel . mht http://www.herbdatanz.com/resin_1htm. ‘Ion Exchange Resins in Formulation : An Update”vol . 5 issue 1, 2007 By,Mrs . Ashwini R. Madgulkar

PowerPoint Presentation:

THANK YOU………..

authorStream Live Help