TABLET MANUFACTURING AND IT�S DIFFERENT ASPECTS

Download
Share  Add to  Flag Embed
Views:
 
Category: Science & Tech..
     
 
License:   All Rights Reserved

Presentation Description

No description available.

Comments

 

By: rajupandhare (5 month(s) ago)

sir i need this ppt. for my work,can u please send me a copy on rajupandhare911@yahoo.com

 

By: syahumaira (5 month(s) ago)

very nice presentation .. how to download it?

 

By: bapujipharmacy (7 month(s) ago)

Very nice presentation.. Please can u snd this ppt..? email:sanju.m007@gmail.com

 

By: hiru87 (7 month(s) ago)

would u plz send this ppt in to my mail at mdgoffar@gmail.com

 

By: dkavitha1 (8 month(s) ago)

I want to download it. please give me the link r mail to me. my id damakavitha@gmail.com

See all

Presentation Transcript

TABLET MANUFACTURING AND IT’S DIFFERENT ASPECTS. :

TABLET MANUFACTURING AND IT’S DIFFERENT ASPECTS. Force distribution and measurement of forces. Process of compression. Strength of tablet and factors affecting. Influencing factors in flow of powder . PRESENTED BY :- NIRANJAN UPADHYAY. M.Pharma. (1 st yr.). PHARMACEUTICS. NIMS UNIVERSITY.

TABLETS:-:

TABLETS:- A Tablet is a pharmaceutical dosage form. It comprises a mixture of active substances and excipients , usually in powder form, pressed or compacted from a powder into a solid dosage. Advantages of tablets :- Production aspect Large scale production at lowest cost Easiest and cheapest to package and ship High stability

Slide 3:

User aspect (doctor, pharmacist, patient) Easy to handling. Lightest and most compact. Coating can mark unpleasant tastes & improve patient acceptability. Disadvantages of tablets Some drugs may be unsuitable for administration by the oral route. Example – insulin.

Slide 4:

Bitter taste drugs, drugs with an objectionable odor, tablets may require coating , and drug which are sensitive to oxygen or moisture may require encapsulation. For drugs that need to have rapid onset, the oral route may not be suitable. For example salbutamol . Drugs with poor wetting, slow dissolution may be difficult to formulate and manufacture as a tablet. Example - sodium valproate

THE PROCESS OF COMPRESSION :- :

THE PROCESS OF COMPRESSION :- Compression is the process of applying pressure to a material. The events that occur in the process of compression: 1) Transitional repacking. 2) Deformation at point of contact. 3) Fragmentation or deformation. 4) Bonding. 5) Deformation of the solid body. 6) Decompression . 7) Ejection.

Slide 7:

Working of automatic tablet punching machine.

Tablet punching machines:-:

Tablet punching machines :- Automatic . Single punch. Old machine

Factors affecting the powder flow rate:-:

Factors affecting the powder flow rate :-

:

1)Material properties Bulk density. Cohesion. Powder internal friction. Powder wall friction. Powder permeability. 2)Feed system Active feeding. Hopper design.(mass flow vs funnel flow) Constrictions.(outlet size, valves, etc.) Agitation conditions.(speed, direction, etc)

1)Bulk density.:

1) Bulk density . The bulk density of a powder blend is predicted during simple volumetric mixing rules. Example calculation :- – blender • 2000L volume • Maximum fill level is 70% of total volume – 70% of 2000L= 1400L

2) Cohesion.:

2) Cohesion . The intermolecular attraction between like-molecules. Glidants are used to promote powder flow by reducing interparticle friction and cohesion . Examples of glidants include magnesium stearate . talc

Powder permeability:

Powder permeability

2)Feed system :

2)Feed system 1) active feeding. Hopper angle θ = 55° • Powder friction μ = 0.84, δ = 25° • Wall friction μ w = 0.84, φ w = 40°

2)Hopper design.(mass flow vs funnel flow):

Ensure mass flow (and avoid funnel flow) – Reduce the friction between hopper and powder (“wall friction”) – Use an appropriate hopper design Wall angles Shape (wedge or conical) Outlet dimensions (large enough to prevent bridging & rat-holes) 2)Hopper design.(mass flow vs funnel flow)

A simple empirical model for maximum powder flow rate:

A simple empirical model for maximum powder flow rate

Another model for powder flow rate:

Another model for powder flow rate

How do I manage all these parameters?:

How do I manage all these parameters? By using material property tests. – to detect unusual or extreme properties – to ensure lot-to-lot consistency. By understanding the factors specific to your equipment. – Every tablet press filler is different. – Conduct a careful design of the commercial scale equipment.

Slide 20:

By identifying the most important factors for your system. – By systematically studying each factor in order to controlling the other factors. Material considerations. • What are the bulk properties of the blend?

Slide 21:

Look out for: Is it easily fluidized? Is it very cohesive? Is it very compressible? Low bulk density? Impermeable to air? Highly frictional with equipment? Unusual particle size? Otherwise difficult to handle?

Equipment considerations:

Equipment considerations Are there any restrictions to rapid powder flow? Half open butterfly valves. Are any of the active feeding components rate limiting? Narrow openings Slow paddle feeders

Slide 23:

Do I have mass flow, or not? Rat holes and/or funnel flow patterns can restrict or disrupt powder flow rates. Can air easily vent from the system? If not, this may reduce or disrupt the powder flow

REFERENCES:- :

REFERENCES :- Leon Lachman , Herbert A.Lieberman , “ The Theory and practice of Industrial Pharmacy” Third edition. Page no:-293-331. Leon Lachman , Herbert A.Lieberman , “ Solid Dosage Form: Tablets, volume 1 st page no:-201-235. http://072010.pdfttp://www.natoli.com/mm/files/TT. http://www.pharmainfo.net/tablet-ruling-dosage-form-years/operations-involved-tablet-manufacturing.

Slide 25:

http://www.jenike.com/TechPapers/solve-solids-flow-probs.pdf.

Slide 26:

Thank you. ?