logging in or signing up Narrated Uterine meds (Ch. 63) nelsjaym Download Post to : URL : Related Presentations : Let's Connect Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 189 Category: Education License: All Rights Reserved Like it (0) Dislike it (0) Added: December 02, 2011 This Presentation is Public Favorites: 0 Presentation Description Pharmacology Comments Posting comment... Premium member Presentation Transcript Chapter 63: Chapter 63 Drugs That Affect Uterine FunctionDrugs That Affect Uterine Function: Drugs That Affect Uterine Function Three main categories Uterine relaxants (tocolytics) Suppression of preterm labor Uterine stimulants (oxytocics) Induction/augmentation of labor Control of postpartum bleeding Induction of abortion Drugs used to promote cervical ripeningPreterm Birth: Preterm Birth Before 37 weeks gestation Leading cause of infant morbidity and neonatal mortality U.S. – 12.5% of all live births Premature births account for 75% of all neonatal mortality 50% of congenital neurologic deficits Most common neonatal respiratory distress syndromeUterine Relaxants (Tocolytics): Uterine Relaxants (Tocolytics) Used to delay delivery Average delay – only 48 hours If used with glucocorticoids, the glucocorticoids can accelerate lung development Also used to buy time to treat infection See Box 63-1Uterine Relaxants (Tocolytics): Uterine Relaxants (Tocolytics) Beta 2 -selective adrenergic agonists Terbutaline ( Brethine ) Beta 2 -selective adrenergic agonist Not approved by FDA for this useUterine Stimulants (Oxytocics): Uterine Stimulants (Oxytocics) Three groups of uterine stimulants Oxytocin Ergot alkaloids ProstaglandinsUterine Stimulants (Oxytocics): Uterine Stimulants (Oxytocics) Oxytocin (Pitocin) Peptide hormone produced by the posterior pituitary Increases the force, frequency, and duration of uterine contractions Uterus becomes progressively more responsive to oxytocin throughout pregnancy Facilitates labor, but unclear if it can initiate laborUterine Stimulants (Oxytocics): Uterine Stimulants (Oxytocics) Oxytocin (Pitocin) (cont ’ d) Physiologic and pharmacologic effects Uterine stimulation Milk ejection Water retention Precautions and contraindications Uterine rupture may occur Women with active genital herpes Adverse effect – water retention/intoxicationUterine Stimulants (Oxytocics): Uterine Stimulants (Oxytocics) Carboprost tromethamine (Hemabate) Preferred agent for controlling postpartum hemorrhage Causes intense uterine contractions Adverse effects GI reactions Vomiting and diarrhea Fever Vasoconstriction Constriction of the bronchiDrugs Used to Promote Cervical Ripening: Drugs Used to Promote Cervical Ripening Dinoprostone (Prepidil, Cervidil) Dinoprostone gel Dinoprostone vaginal inserts (Cervidil) Misoprostol (Cytotec) Not approved for this use You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.