logging in or signing up Receptors, Agonists, Antagonists neilcredo Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 4008 Category: Education License: All Rights Reserved Like it (5) Dislike it (0) Added: September 12, 2008 This Presentation is Public Favorites: 3 Presentation Description Neil Credo, Victor Quiniano, Fall 2008 Comments Posting comment... By: alaher1970 (16 month(s) ago) its great and usefull presintation & i need it if alloud me to download it Saving..... Post Reply Close Saving..... Post Reply Close Saving..... Edit Comment Close By: vetvet2008 (17 month(s) ago) its great and usefull presintation & i need it if alloud me to download it Saving..... Post Reply Close Saving..... Edit Comment Close By: jamal112 (18 month(s) ago) its great and usefull presintation & i need it if alloud me to download it Saving..... Post Reply Close Saving..... Edit Comment Close By: kbsc (19 month(s) ago) hey this is a very good presentation of drug receptors. Saving..... Post Reply Close Saving..... Edit Comment Close By: Shaffigupta (20 month(s) ago) heyy!!!!! thanks 4 uploading sch an informative and interesting presentation...... please send it to my email... shaffigupta39@gmail.com Saving..... Post Reply Close Saving..... Edit Comment Close loading.... See all Premium member Presentation Transcript Receptors, Agonists and Antagonists : Receptors, Agonists and Antagonists Presented by: OUCN Fall 2008 TEAM QC Neil Credo Victor Quiniano RECEPTORS : RECEPTORS Definition Receptors are special “Chemicals” in the body that most drugs interact with to produce effects. Receptors : Receptors A receptor is a functional macromolecule in a cell to which a drug binds to produce its effect. The term is generally reserved for what is arguably the most important group of macromolecules through which drugs act: the body’s own receptors for hormones, neurotransmitters, and other regulatory molecules. Formula for Receptors : Formula for Receptors D = Drug R = Receptor D + R ≒ D-R Complex ⇒ RESPONSE Binding of a drug to its receptor is usually REVERSIBLE. Receptors : Receptors A receptor is analogous to a light switch in that it has two configurations: “ON” and “OFF” A receptor must be “ON” to influence cellular function Four Primary Receptor Families : Four Primary Receptor Families Cell membrane-embedded enzymes Ligand-gated ion channels G protein-coupled receptor systems Transcription Factors Agonists : Agonists Definition Agonists are molecules that activate receptors. Agonists : Agonists An agonist is a drug that has both affinity and high intrinsic activity. AFFINITY allows the agonist to bind to receptors. INTRINSIC ACTIVITY allows the bound agonist to “activate” or “turn on “ receptor function. AgonistAffinity and Intrinsic Activity : AgonistAffinity and Intrinsic Activity Agonists : Agonists Many therapeutic agents produce their effects by functioning as agonists. Dobutamine for example, is a drug that mimics the action of NE (norepinephrine) at the receptors on the heart, thereby causing heart rate and force of contraction to increase. Agonists : Agonists Antagonist : Antagonist Definition An antagonist is a drug with affinity for a receptor but with no intrinsic activity. Affinity allows the antagonist to bind to receptors, but lack of intrinsic activity prevents the bound antagonist from causing receptor activation. Antagonist : Antagonist Although antagonists do not cause receptor activation, they most certainly do produce pharmacologic effects. They prevent the activation of receptors by agonists. Antagonist : Antagonist Antagonists can produce beneficial effects by blocking the action of drugs – employed most commonly in the treatment of overdose. Response to an antagonist is determined by how much agonist is present. If there is no agonist present, administration of an antagonist will have no observable effect. Antagonist : Antagonist Receptors, Agonists and Antagonists : Receptors, Agonists and Antagonists Theories of Drug-Receptor Interaction Simple Occupancy Theory Intensity of the response to a drug is proportional to the number of receptors occupied by that drug. A maximal response will occur when all available receptors have been occupied. The Modified Occupancy Theory The ability to bind to the receptor The ability to influence receptor function once binding has taken place. References : References Lehne, R. (2007). Pharmacology for Nursing Care (6th Ed.). St. Louis, Saunders Elsevier. http://images.search.yahoo.com/images/view?back=http You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
Receptors, Agonists, Antagonists neilcredo Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 4008 Category: Education License: All Rights Reserved Like it (5) Dislike it (0) Added: September 12, 2008 This Presentation is Public Favorites: 3 Presentation Description Neil Credo, Victor Quiniano, Fall 2008 Comments Posting comment... By: alaher1970 (16 month(s) ago) its great and usefull presintation & i need it if alloud me to download it Saving..... Post Reply Close Saving..... Post Reply Close Saving..... Edit Comment Close By: vetvet2008 (17 month(s) ago) its great and usefull presintation & i need it if alloud me to download it Saving..... Post Reply Close Saving..... Edit Comment Close By: jamal112 (18 month(s) ago) its great and usefull presintation & i need it if alloud me to download it Saving..... Post Reply Close Saving..... Edit Comment Close By: kbsc (19 month(s) ago) hey this is a very good presentation of drug receptors. Saving..... Post Reply Close Saving..... Edit Comment Close By: Shaffigupta (20 month(s) ago) heyy!!!!! thanks 4 uploading sch an informative and interesting presentation...... please send it to my email... shaffigupta39@gmail.com Saving..... Post Reply Close Saving..... Edit Comment Close loading.... See all Premium member Presentation Transcript Receptors, Agonists and Antagonists : Receptors, Agonists and Antagonists Presented by: OUCN Fall 2008 TEAM QC Neil Credo Victor Quiniano RECEPTORS : RECEPTORS Definition Receptors are special “Chemicals” in the body that most drugs interact with to produce effects. Receptors : Receptors A receptor is a functional macromolecule in a cell to which a drug binds to produce its effect. The term is generally reserved for what is arguably the most important group of macromolecules through which drugs act: the body’s own receptors for hormones, neurotransmitters, and other regulatory molecules. Formula for Receptors : Formula for Receptors D = Drug R = Receptor D + R ≒ D-R Complex ⇒ RESPONSE Binding of a drug to its receptor is usually REVERSIBLE. Receptors : Receptors A receptor is analogous to a light switch in that it has two configurations: “ON” and “OFF” A receptor must be “ON” to influence cellular function Four Primary Receptor Families : Four Primary Receptor Families Cell membrane-embedded enzymes Ligand-gated ion channels G protein-coupled receptor systems Transcription Factors Agonists : Agonists Definition Agonists are molecules that activate receptors. Agonists : Agonists An agonist is a drug that has both affinity and high intrinsic activity. AFFINITY allows the agonist to bind to receptors. INTRINSIC ACTIVITY allows the bound agonist to “activate” or “turn on “ receptor function. AgonistAffinity and Intrinsic Activity : AgonistAffinity and Intrinsic Activity Agonists : Agonists Many therapeutic agents produce their effects by functioning as agonists. Dobutamine for example, is a drug that mimics the action of NE (norepinephrine) at the receptors on the heart, thereby causing heart rate and force of contraction to increase. Agonists : Agonists Antagonist : Antagonist Definition An antagonist is a drug with affinity for a receptor but with no intrinsic activity. Affinity allows the antagonist to bind to receptors, but lack of intrinsic activity prevents the bound antagonist from causing receptor activation. Antagonist : Antagonist Although antagonists do not cause receptor activation, they most certainly do produce pharmacologic effects. They prevent the activation of receptors by agonists. Antagonist : Antagonist Antagonists can produce beneficial effects by blocking the action of drugs – employed most commonly in the treatment of overdose. Response to an antagonist is determined by how much agonist is present. If there is no agonist present, administration of an antagonist will have no observable effect. Antagonist : Antagonist Receptors, Agonists and Antagonists : Receptors, Agonists and Antagonists Theories of Drug-Receptor Interaction Simple Occupancy Theory Intensity of the response to a drug is proportional to the number of receptors occupied by that drug. A maximal response will occur when all available receptors have been occupied. The Modified Occupancy Theory The ability to bind to the receptor The ability to influence receptor function once binding has taken place. References : References Lehne, R. (2007). Pharmacology for Nursing Care (6th Ed.). St. Louis, Saunders Elsevier. http://images.search.yahoo.com/images/view?back=http