logging in or signing up alzheimer disease neet463 Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 13417 Category: Education License: All Rights Reserved Like it (6) Dislike it (0) Added: January 23, 2010 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... By: nimisha1172 (28 month(s) ago) informative ppt... please send me it on firstname.lastname@example.org Saving..... Post Reply Close Saving..... Edit Comment Close By: zainab94 (37 month(s) ago) It is useful presentation, the pictures make it very nice. Saving..... Post Reply Close Saving..... Edit Comment Close Premium member Presentation Transcript Alzheimer's DISEASE : Alzheimer's DISEASE INTRODUCTION : INTRODUCTION Neurodegenerative disorder most common cause of dementia in elderly Clinically, apparent as insidious impairment of higher intellectual function, with alteration in mood and behaviour ● Later, progressive disorientation, memory loss and aphasia, indicate severe cortical dysfunction ● Later, patient becomes disabled, mute and immobile : ● Later, progressive disorientation, memory loss and aphasia, indicate severe cortical dysfunction ● Later, patient becomes disabled, mute and immobile Morphology : Morphology ● Variable degree of cortical atrophy, widening of the cerebral sulci in frontal, parietal, temporal lobe● Microscopic abnormalities: a) Neuritic plaques b) Neurofibrillary tangles c) Amyloid angiopathy Neuritic plaques : Neuritic plaques Neuritic plaques are focal, spherical collections of dilated, tortuous neuritic processes (dystrophic neurites) around a central amyloid core Range in size from 20-200 m in diameter Microglial cells and astrocytes present peripherally Found in hippocampus and amygdala Slide 7: Dystrophic neurites contains abnormal synaptic vesicles and mitochondria Amyloid core contain several abnormal proteins, predominantly, Aβ (derived from APP) Other components: components of complement cascade, proinflammatory cytokines, apolipoproteins Slide 8: Neurofibrillary tangles are bundles of filaments in the cytoplasm of neurons that displace or encircle the nucleus Commonly found in cortical neurons, amygdala, hippocampus, forebrain Composed of paired helical filaments along with some straight filaments Slide 9: ● Major component of paired helical filaments is abnormally hyperphosphorylated form of protein, tau, (tau is an axonal microtubule-associated protein that enhances microtubule assembly) ● Cerebral amyloid angiopathy (CAA) : deposition of Aβ40 Slide 10: Granulovascular degeneration: formation of small, clear intraneuronal cytoplasmic vacuoles In hippocampus, olfactory bulb Slide 11: Normal brain AD Brain Pathogenesis : Pathogenesis Symptoms : Symptoms -- Initial Forgetfulness; other memory disturbances Language deficits Loss of learned motor skills Loss of mathematical skills -- Finally Patient become mute; unable to walk You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.