logging in or signing up aerosols narendar.k Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 736 Category: Education License: Some Rights Reserved Like it (0) Dislike it (0) Added: November 05, 2010 This Presentation is Public Favorites: 3 Presentation Description No description available. Comments Posting comment... By: ephraiem (8 month(s) ago) sir plz can u send this pwr point to my mail id ephraiem.g@gmail.com Saving..... Post Reply Close Saving..... Edit Comment Close By: ephraiem (8 month(s) ago) sir plz can u send this pwr point to my mail id ephraiem.g@gmail.com Saving..... Post Reply Close Saving..... Edit Comment Close By: aboareda (15 month(s) ago) Dear Sir please send me this PPT ,as we now about to open new aerosol line, so i need your help redahamed4790@yahoo.com Saving..... Post Reply Close Saving..... Edit Comment Close By: faris.r (16 month(s) ago) why :@ Saving..... Post Reply Close Saving..... Edit Comment Close By: sundarmpharm (17 month(s) ago) sir plz can u send this pwr point to my mail id sundar.ceutics@rediffmail.com Saving..... Post Reply Close Saving..... Edit Comment Close Premium member Presentation Transcript Slide 1: Amit M Gupta 1 PHARMACEUTICAL AEROSOLs Narendar K Narendar reddyVishnu institute of pharmaceutical education & research Vishnupur,Narsapur, Medak (dt), AP Slide 2: Definition Packaging of therapeutic active ingredients in a pressurized system. Aerosols are depends on the power of compressed or liquefied gas to expel the contents from containers. Narendar Slide 3: Amit M Gupta 3 Advantages A dose can be removed with out contamination of materials. The medication can be delivered directly to the affected area in a desired form, such as spray, steam, quick breaking foam or stable foam. Irritation produced by the mechanical application of topical medication is reduced or eliminated. Ease of convenience of application. Application of medication in thin layer Narendar Slide 4: Amit M Gupta 4 Components of aerosols Propellant Container Valve and actuator Product concentrate container Narendar Slide 5: Amit M Gupta 5 Propellant #It is responsible for developing the power pressure with in the container and also expel the product when the valve is opened and in the atomization or foam production of the product. # For oral and inhalation eg. Fluorinated hydrocarbons Dichlorodifluromethane (propellent 12) Dichlorotetrafluromethane (propellent 114) # Topical preparation Propane Butane Isobutane # Compound gases Nitrogen Carbon di oxide Nitrous oxide Narendar Slide 6: Amit M Gupta 6 Containers They must be stand at pressure as high as 140 to 180 psig (pounds per sq. inch gauge) at 1300 F. A. Metals 1. Tinplated steel (a) Side-seam (three pieces) (b) Two-piece or drawn (c) Tin free steel 2. Aluminium (a) Two-piece (b) One-piece (extruded or drawn) 3. Stainless steel B. Glass 1. Uncoated glass 2. Plastic coated glass Narendar Slide 7: Amit M Gupta 7 Physiochemical properties of propellants Vapor pressure Boiling points Liquid density Narendar Slide 8: Amit M Gupta 8 Valves To delivered the drug in desired form. To give proper amount of medication. Not differ from valve to valve of medication in pharmaceutical preparation. Types - Continuous spray valve - High speed production technique. - Metering valves Dispersing of potent medication at proper dispersion/ spray approximately 50 to 150 mg ±10 % of liquid materials at one time use of same valve. Narendar Slide 9: Amit M Gupta 9 Valve components Ferrul or mount cap Valve body or housing Stem Gasket Spring Dip tube Gasket spring Narendar Slide 10: Amit M Gupta 10 Actuator To ensure that aerosol product is delivered in the proper and desired form. Different types of actuators Spray actuators Foam actuators Solid steam actuators Special actuators Narendar Slide 11: Amit M Gupta 11 Metered dose inhaler To increased interest in modifying metered dose inhalers (MDIs) to minimize the number of administration error and to improve the drug delivery of aerosols particles into the drug delivery system of the nasal passageways and respiratory tract. Narendar Slide 12: Amit M Gupta 12 Formulation of pharmaceutical aerosols Contains two essential components Product concentrate Propellant Product concentrate Product concentrate contains ingredients or mixture of active ingredients and other such as solvents, antioxidants and surfactants. Propellant May be single or blend of various propellants Blends of propellant used in a p’ceutical formulation to achieve desired solubility characteristics or various surfactants are mixed to give the proper HLB value for emulsion system. To give the desired vapor pressure, solubility & particle size. Narendar Slide 13: Amit M Gupta 13 Parameters consideration Physical, chemical and p’ceutical properties of active ingredients. Site of application Narendar Slide 14: Amit M Gupta 14 Types of system Solution system Water based system Suspension or Dispersion systems Foam systems 1. Aqueous stable foams 2. Nonaqueous stable foams 3. Quick-breaking foams 4. Thermal foams Intranasal aerosols Narendar Slide 15: Amit M Gupta 15 Manufacturing of Pharmaceutical Aerosols Apparatus Pressure filling apparatus Cold filling apparatus Compressed gas filling apparatus Narendar Slide 16: Amit M Gupta 16 Quality control for pharmaceutical aerosols Propellants Valves, actuator and dip tubes Testing procedure Valve acceptance Containers Weight checking Leak testing Spray testing Narendar Slide 17: Amit M Gupta 17 Evaluation parameters of pharmaceutical aerosols A. Flammability and combustibility Flash point Flame extension, including flashback B. Physiochemical characteristics 1. Vapor pressure Density Moisture content Identification of propellant(s) Concentrate-propellant ratio C. Performance 1. Aerosol valve discharge rate Spray pattern Dosage with metered valves Net contents Foam stability Particle size determination Leakage D. Biologic characteristics E. Therapeutic activity Narendar Slide 18: Amit M Gupta 18 Flame Projection ** This test indicates the effect of an aerosol formulation on the extension of an open flame. ** Product is sprayed for 4 sec. into flame. ** Depending on the nature of formulation, the fame is extended, and exact length was measured with ruler. Narendar Slide 19: Amit M Gupta 19 Flash point Determined by using standard Tag Open Cap Apparatus. Step involves are Aerosol product is chilled to temperature of - 25 0 F and transferred to the test apparatus. Temperature of test liquid increased slowly, and the temperature at which the vapors ignite is taken a flash point. Calculated for flammable component, which in case of topical hydrocarbons. Narendar Slide 20: Amit M Gupta 20 Vapor pressure Determined by pressure gauge Variation in pressure indicates the presence of air in headspace. A can punctuating device is available for accurately measuring vapor pressure. Narendar Slide 21: Amit M Gupta 21 Density Determined by hydrometer or a pycnometer. Step involves are A pressure tube is fitted with metal fingers and hoke valve, which allow for the introduction of liquids under pressure. The hydrometer is placed in to the glass pressure tube. Sufficient sample is introduced through the valve to cause the hydrometer to rise half way up the length of the tube. The density can be read directly. Narendar Slide 22: Amit M Gupta 22 Moisture content Method used — Karl Fischer method G. C has also been used Identification of propellants G.C, I.R spectrophotometry Aerosol valve discharge rate Determined by taking an aerosol known weight and discharging the contents for given time using standard apparatus. By reweighing the container after time limit has expired, the change in weight per time dispensed is discharge rate, Expressed as gram per seconds. Narendar Slide 23: Amit M Gupta 23 Dosage with metered valves Amt. of medication actually received by the patient. Reproducibility has been determined by assay technique, Another method is that, involves accurate weighing of filled container fallowed by dispersing of several doses, container can reweighed, and difference in weight divided by No. of dose, gives the average dosage. Reproducibility of dosage each time the valve is dispersed Narendar Slide 24: Amit M Gupta 24 Net contents Weight method Filled full container, and dispensing the contents Foam stability Visual evaluation Time for a given mass to penetrate the foam Times for given rod that is inserted into the foam to fall The use of rotational viscometers Narendar Slide 25: Amit M Gupta 25 Particle size determination Cascade impactor Light scatter decay method Cascade impactor Operates on the projected through a series of nozzle and glass slides at high viscosity, the large particles become impacted first on the lower velocity stages, and the smaller particals pass on and are collected at high velocity stages. These practical ranging from 0.1 to 30 micron and retaining on RTI. Modification made to improve efficacy Cascade impctor Narendar Slide 26: Amit M Gupta 26 Porush, Thiel and Young used light scattering method to determine particle size. As aerosols settle in turbulent condition , the change in light intensity of Tyndall beam is measured Sciarra and Cutie developed method based on practical size distribution. Narendar You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
aerosols narendar.k Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 736 Category: Education License: Some Rights Reserved Like it (0) Dislike it (0) Added: November 05, 2010 This Presentation is Public Favorites: 3 Presentation Description No description available. Comments Posting comment... By: ephraiem (8 month(s) ago) sir plz can u send this pwr point to my mail id ephraiem.g@gmail.com Saving..... Post Reply Close Saving..... Edit Comment Close By: ephraiem (8 month(s) ago) sir plz can u send this pwr point to my mail id ephraiem.g@gmail.com Saving..... Post Reply Close Saving..... Edit Comment Close By: aboareda (15 month(s) ago) Dear Sir please send me this PPT ,as we now about to open new aerosol line, so i need your help redahamed4790@yahoo.com Saving..... Post Reply Close Saving..... Edit Comment Close By: faris.r (16 month(s) ago) why :@ Saving..... Post Reply Close Saving..... Edit Comment Close By: sundarmpharm (17 month(s) ago) sir plz can u send this pwr point to my mail id sundar.ceutics@rediffmail.com Saving..... Post Reply Close Saving..... Edit Comment Close Premium member Presentation Transcript Slide 1: Amit M Gupta 1 PHARMACEUTICAL AEROSOLs Narendar K Narendar reddyVishnu institute of pharmaceutical education & research Vishnupur,Narsapur, Medak (dt), AP Slide 2: Definition Packaging of therapeutic active ingredients in a pressurized system. Aerosols are depends on the power of compressed or liquefied gas to expel the contents from containers. Narendar Slide 3: Amit M Gupta 3 Advantages A dose can be removed with out contamination of materials. The medication can be delivered directly to the affected area in a desired form, such as spray, steam, quick breaking foam or stable foam. Irritation produced by the mechanical application of topical medication is reduced or eliminated. Ease of convenience of application. Application of medication in thin layer Narendar Slide 4: Amit M Gupta 4 Components of aerosols Propellant Container Valve and actuator Product concentrate container Narendar Slide 5: Amit M Gupta 5 Propellant #It is responsible for developing the power pressure with in the container and also expel the product when the valve is opened and in the atomization or foam production of the product. # For oral and inhalation eg. Fluorinated hydrocarbons Dichlorodifluromethane (propellent 12) Dichlorotetrafluromethane (propellent 114) # Topical preparation Propane Butane Isobutane # Compound gases Nitrogen Carbon di oxide Nitrous oxide Narendar Slide 6: Amit M Gupta 6 Containers They must be stand at pressure as high as 140 to 180 psig (pounds per sq. inch gauge) at 1300 F. A. Metals 1. Tinplated steel (a) Side-seam (three pieces) (b) Two-piece or drawn (c) Tin free steel 2. Aluminium (a) Two-piece (b) One-piece (extruded or drawn) 3. Stainless steel B. Glass 1. Uncoated glass 2. Plastic coated glass Narendar Slide 7: Amit M Gupta 7 Physiochemical properties of propellants Vapor pressure Boiling points Liquid density Narendar Slide 8: Amit M Gupta 8 Valves To delivered the drug in desired form. To give proper amount of medication. Not differ from valve to valve of medication in pharmaceutical preparation. Types - Continuous spray valve - High speed production technique. - Metering valves Dispersing of potent medication at proper dispersion/ spray approximately 50 to 150 mg ±10 % of liquid materials at one time use of same valve. Narendar Slide 9: Amit M Gupta 9 Valve components Ferrul or mount cap Valve body or housing Stem Gasket Spring Dip tube Gasket spring Narendar Slide 10: Amit M Gupta 10 Actuator To ensure that aerosol product is delivered in the proper and desired form. Different types of actuators Spray actuators Foam actuators Solid steam actuators Special actuators Narendar Slide 11: Amit M Gupta 11 Metered dose inhaler To increased interest in modifying metered dose inhalers (MDIs) to minimize the number of administration error and to improve the drug delivery of aerosols particles into the drug delivery system of the nasal passageways and respiratory tract. Narendar Slide 12: Amit M Gupta 12 Formulation of pharmaceutical aerosols Contains two essential components Product concentrate Propellant Product concentrate Product concentrate contains ingredients or mixture of active ingredients and other such as solvents, antioxidants and surfactants. Propellant May be single or blend of various propellants Blends of propellant used in a p’ceutical formulation to achieve desired solubility characteristics or various surfactants are mixed to give the proper HLB value for emulsion system. To give the desired vapor pressure, solubility & particle size. Narendar Slide 13: Amit M Gupta 13 Parameters consideration Physical, chemical and p’ceutical properties of active ingredients. Site of application Narendar Slide 14: Amit M Gupta 14 Types of system Solution system Water based system Suspension or Dispersion systems Foam systems 1. Aqueous stable foams 2. Nonaqueous stable foams 3. Quick-breaking foams 4. Thermal foams Intranasal aerosols Narendar Slide 15: Amit M Gupta 15 Manufacturing of Pharmaceutical Aerosols Apparatus Pressure filling apparatus Cold filling apparatus Compressed gas filling apparatus Narendar Slide 16: Amit M Gupta 16 Quality control for pharmaceutical aerosols Propellants Valves, actuator and dip tubes Testing procedure Valve acceptance Containers Weight checking Leak testing Spray testing Narendar Slide 17: Amit M Gupta 17 Evaluation parameters of pharmaceutical aerosols A. Flammability and combustibility Flash point Flame extension, including flashback B. Physiochemical characteristics 1. Vapor pressure Density Moisture content Identification of propellant(s) Concentrate-propellant ratio C. Performance 1. Aerosol valve discharge rate Spray pattern Dosage with metered valves Net contents Foam stability Particle size determination Leakage D. Biologic characteristics E. Therapeutic activity Narendar Slide 18: Amit M Gupta 18 Flame Projection ** This test indicates the effect of an aerosol formulation on the extension of an open flame. ** Product is sprayed for 4 sec. into flame. ** Depending on the nature of formulation, the fame is extended, and exact length was measured with ruler. Narendar Slide 19: Amit M Gupta 19 Flash point Determined by using standard Tag Open Cap Apparatus. Step involves are Aerosol product is chilled to temperature of - 25 0 F and transferred to the test apparatus. Temperature of test liquid increased slowly, and the temperature at which the vapors ignite is taken a flash point. Calculated for flammable component, which in case of topical hydrocarbons. Narendar Slide 20: Amit M Gupta 20 Vapor pressure Determined by pressure gauge Variation in pressure indicates the presence of air in headspace. A can punctuating device is available for accurately measuring vapor pressure. Narendar Slide 21: Amit M Gupta 21 Density Determined by hydrometer or a pycnometer. Step involves are A pressure tube is fitted with metal fingers and hoke valve, which allow for the introduction of liquids under pressure. The hydrometer is placed in to the glass pressure tube. Sufficient sample is introduced through the valve to cause the hydrometer to rise half way up the length of the tube. The density can be read directly. Narendar Slide 22: Amit M Gupta 22 Moisture content Method used — Karl Fischer method G. C has also been used Identification of propellants G.C, I.R spectrophotometry Aerosol valve discharge rate Determined by taking an aerosol known weight and discharging the contents for given time using standard apparatus. By reweighing the container after time limit has expired, the change in weight per time dispensed is discharge rate, Expressed as gram per seconds. Narendar Slide 23: Amit M Gupta 23 Dosage with metered valves Amt. of medication actually received by the patient. Reproducibility has been determined by assay technique, Another method is that, involves accurate weighing of filled container fallowed by dispersing of several doses, container can reweighed, and difference in weight divided by No. of dose, gives the average dosage. Reproducibility of dosage each time the valve is dispersed Narendar Slide 24: Amit M Gupta 24 Net contents Weight method Filled full container, and dispensing the contents Foam stability Visual evaluation Time for a given mass to penetrate the foam Times for given rod that is inserted into the foam to fall The use of rotational viscometers Narendar Slide 25: Amit M Gupta 25 Particle size determination Cascade impactor Light scatter decay method Cascade impactor Operates on the projected through a series of nozzle and glass slides at high viscosity, the large particles become impacted first on the lower velocity stages, and the smaller particals pass on and are collected at high velocity stages. These practical ranging from 0.1 to 30 micron and retaining on RTI. Modification made to improve efficacy Cascade impctor Narendar Slide 26: Amit M Gupta 26 Porush, Thiel and Young used light scattering method to determine particle size. As aerosols settle in turbulent condition , the change in light intensity of Tyndall beam is measured Sciarra and Cutie developed method based on practical size distribution. Narendar