Drug Interactions of Niacin

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Niacin can interact with drugs such as Statins (Simvastatin, Rosuvastatin, Atorvastatin, Lovastatin, etc) and warfarin, significantly.

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Drug Interactions of Antihyperlipidemics Part 4 (Drug Interactions of Niacin):

Drug Interactions of Antihyperlipidemics Part 4 ( Drug Interactions of Niacin ) D r . P.Naina Mohamed P h D P harmacologist

Introduction:

Introduction An adverse drug interaction is defined as an interaction between one or more coadministered medications which leads to alteration of the effectiveness or toxicity of any of the coadministered medications. Drug interactions can be caused by P rescription and Over-the-counter (OTC) medications, herbal products or vitamins, foods, diseases, and genetics (family history). It is estimated that people over 65 take an average of seven drugs at any one time to treat a variety of illnesses including higher cholesterol, diabetes, hypertension, etc. With this amount of medicine use, the probability that a person will take two prescribed drugs that may interact with one another is very high.

Antihyperlipidemics:

Antihyperlipidemics Statins (HMG CoA Reductase Inhibitors) Fibrates Bile acid S equestrants Niacin Ezetimibe Lomitapide Orlistat

Niacin & Statins:

Niacin & Statins If coadministration of Niacin and Statins is required, monitor the patient for signs and symptoms of myopathy or rhabdomyolysis (Muscle pain, Tenderness , or weakness ). Periodic creatine kinase (CK) determinations may be advisable . http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110829 /

Niacin & Warfarin:

Niacin & Warfarin More frequent monitoring of INR and/or prothrombin time is recommended, if concomitant therapy is required. http:// aop.sagepub.com/content/45/11/e58.long

Conclusion:

Conclusion The occurrence of significant morbidity and mortality can be reduced by minimizing the risk for drug interactions. The hyperlipidemic patients should bring a list of all the drugs they are taking including prescription drugs, over-the-counter drugs, and any supplements, herbal or otherwise, during their visit to the doctor or pharmacist . The risk of adverse effects could be reduced and the quality of life for patients improved by healthcare professionals through the screening , education, and follow up on suspected drug interactions. If possible, the hyperlipidemic patients are recommended to fill all their prescriptions at one pharmacy.

References:

References Stockley’s Drug Interactions, 9e Karen Baxter Hurst's The Heart, 13e Valentin Fuster , Richard A. Walsh, Robert A. Harrington Basic & Clinical Pharmacology, 12e Bertram G. Katzung , Susan B. Masters, Anthony J. Trevor http :// www.micromedexsolutions.com

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