Research Protocol for Medicinal and Pharmaceutical Chemistry

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To help young researchers in Medicinal Chemistry, Pharmaceutical Chemistry, Drug Design, Lead Optimization, etc., to understand the major important steps involved in the research work

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Introduction to Research Protocol for Pharmaceutical and Medicinal Chemistry Research Department of Pharmaceutical Chemistry Annamacharya College of Pharmacy New Boyanapalli Rajampet - 516126 12/19/2016 1 By M. Nagendra Babu

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12/19/2016 3 IDENTIFICATION OF PROBLEM Problem Disease Target Toxicities of Drugs Drug Resistance

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12/19/2016 4 LITERATURE Journals/Books/Articles/Scientific Magazines Patents Reports Debates by Pharma. Industries during Conferences

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12/19/2016 5 AIM OBJECTIVES Lead Identification and Optimization Synthesis of Optimized Derivatives Characterization of Synthesized Derivatives Biological Screening To Synthesize Novel Derivatives of Therapeutic Potential

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12/19/2016 6 RESEARCH PROTOCOL Selection of Lead Optimization of Lead Synthesis of Optimized Structural Analogs Characterization of Synthesized Analogs Biological Screening

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12/19/2016 7 SELECTION OF LEAD Lead Pharmaco phore Pharmaco phore Pharmaco phore Pharmaco phore N NH O NH 2

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12/19/2016 8 OPTIMIZATION OF LEAD

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12/19/2016 9 SYNTHESIS OF OPTIMIZED STRUCTURAL ANALOGS

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12/19/2016 10 CHARACTERIZATION OF SYNTHESIZED ANALOGS IR • Identification of functional groups NMR • Identification of number nature of protons • Identification of number of carbons Mass • Identification of molecular mass

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12/19/2016 11 BIOLOGICAL SCREENING In-vitro Assays Toxicity Assays In-vitro in-vivo Ex-vivo Assays In-vivo Assays B i o l o g i c a l s c r e e n i n g M e t h o d s

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