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Shigella : 

Shigella By/ Mohamed Tag elDin Mohamed 4th Microbiology

Identification : 

Rod like shape Gram negative Negative with motility test Non-spore former Non-lactose fermentor Non-acid or gas producer Don’t hydrolyze urea Classified as Enterobactereacae Identification

Pathogenesis : 

Shigella infection is typically via ingestion Ten bacterial cells can be enough to cause an infection Causes dysentery that results in the destruction of the epithelial cells of the intestinal mucosa in the cecum and rectum Some strains produce enterotoxin and shiga toxin, Both are associated with causing haemolytic uremic syndrome. Shigella’s virulence centering in it’s type 3 secretion system and using host cell components in mobility. Pathogenesis

Symptoms : 

Symptoms Symptoms can take as long as a week to show up The stool may contain blood, mucus, or pus Diarrhea Fever Nausea Vomiting Stomach cramps Laboratory diagnosis by stool culture Shigellosis in the cecum tissue

Slide 5: 

Mode of action

Treatment : 

Severe dysentery can be treated with ampicillin, TMP-SMX, or fluoroquinolones such as ciprofloxacin and of course rehydration. Treatment

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