20060712 Day1 Anatomy Mapping

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The Mouse / Human Anatomy Project : 

The Mouse / Human Anatomy Project Jim Kadin The Jackson Laboratory

mouse-human anatomy project objective: 

mouse-human anatomy project objective To provide a mapping and harmonization of anatomical descriptors as they are currently used for murine and human models by Mouse Genome Informatics and the NCI Thesaurus

Slide3: 

to facilitate closer integration of human and mouse cancer data to promote the use of the mouse as model for cancer research to accelerate translation of basic research discoveries into new clinical therapies

Participants: 

Participants MGI project team Terry Hayamizu Jim Kadin Martin Ringwald NCI project team Sherri De Coronado Gilberto Fragoso Nick Sioutos Wen-Ling Shaiu Frank Hartel BAH Michael Keller Brian Davis NCI VCDE-WS lead George Komatsoulis

mouse-human anatomy project activities: 

mouse-human anatomy project activities Evaluation of ontology editing tools in terms of their utility both for comparison and for mapping In-depth comparative analysis of both ontologies Generation for review of a draft mapping between terms within the existing ontologies Development of a roadmap for extension and harmonization of the ontologies Execution of the roadmap, including mappings between anatomical terms Development of procedures for updating and maintaining the adult mouse anatomy, including the mouse-human mappings, in the NCI Thesaurus

mouse-human anatomy project activities: 

mouse-human anatomy project activities Evaluation of ontology editing tools in terms of their utility both for comparison and for mapping In-depth comparative analysis of both ontologies Generation for review of a draft mapping between terms within the existing ontologies Development of a roadmap for extension and harmonization of the ontologies Execution of the roadmap, including mappings between anatomical terms Development of procedures for updating and maintaining the adult mouse anatomy, including the mouse-human mappings, in the NCI Thesaurus

mouse-human anatomy project activities: 

mouse-human anatomy project activities Evaluation of ontology editing tools in terms of their utility both for comparison and for mapping In-depth comparative analysis of both ontologies Generation for review of a draft mapping between terms within the existing ontologies Development of a roadmap for extension and harmonization of the ontologies Execution of the roadmap, including mappings between anatomical terms Development of procedures for updating and maintaining the adult mouse anatomy, including the mouse-human mappings, in the NCI Thesaurus

Specific Tasks for Comparative Analysis: 

Specific Tasks for Comparative Analysis Compare the anatomy ontologies - e.g. overall structure, local similarities and differences, and differences in granularity Identify reasons for all types of differences. Identify anatomical concepts that are identical and/or equivalent ˛ i.e. “matching terms” Identify concepts defined in one context, but missing in the other ˛ i.e. possible terms to add to other ontology

Slide10: 

Legend Red: non-matching terms Black: matching terms Straight blue lines: terms that match and the ontology structures match Wavy blue lines: terms that match but ontology structures don’t Comparison of High Level Structure

mouse-human anatomy project activities: 

mouse-human anatomy project activities Evaluation of ontology editing tools in terms of their utility both for comparison and for mapping In-depth comparative analysis of both ontologies Generation for review of a draft mapping between terms within the existing ontologies Development of a roadmap for extension and harmonization of the ontologies Execution of the roadmap, including mappings between anatomical terms Development of procedures for updating and maintaining the adult mouse anatomy, including the mouse-human mappings, in the NCI Thesaurus

mouse-human anatomy project activities: 

mouse-human anatomy project activities Evaluation of ontology editing tools in terms of their utility both for comparison and for mapping In-depth comparative analysis of both ontologies Generation for review of a draft mapping between terms within the existing ontologies Development of a roadmap for extension and harmonization of the ontologies Execution of the roadmap, including mappings between anatomical terms Development of procedures for updating and maintaining the adult mouse anatomy, including the mouse-human mappings, in the NCI Thesaurus

Harmonization at the Top Levels: 

Harmonization at the Top Levels

Slide15: 

Example of Detail Level Harmonization Before

Slide16: 

Example of Detail Level Harmonization After

mouse-human anatomy project activities: 

mouse-human anatomy project activities Evaluation of ontology editing tools in terms of their utility both for comparison and for mapping In-depth comparative analysis of both ontologies Generation for review of a draft mapping between terms within the existing ontologies Development of a roadmap for extension and harmonization of the ontologies Execution of the roadmap, including mappings between anatomical terms Development of procedures for updating and maintaining the adult mouse anatomy, including the mouse-human mappings, in the NCI Thesaurus

mouse-human anatomy project activities: 

mouse-human anatomy project activities Evaluation of ontology editing tools in terms of their utility both for comparison and for mapping In-depth comparative analysis of both ontologies Generation for review of a draft mapping between terms within the existing ontologies Development of a roadmap for extension and harmonization of the ontologies Execution of the roadmap, including mappings between anatomical terms Development of procedures for updating and maintaining the adult mouse anatomy, including the mouse-human mappings, in the NCI Thesaurus

Ongoing: 

Ongoing MGI will continue to maintain the MA and mappings Have agreed on procedures for bi-directional updates EVS is working on incorporating MA into the NCI Thesaurus

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