REISHI AND ALZHEIMERS show

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RECENT UPDATES ON REISHI: ON ALZHEIMER’S DISEASE:

RECENT UPDATES ON REISHI: ON ALZHEIMER’S DISEASE Gene JM Dillague, MD Chief Science Officer

ALZHEIMER’S DISEASE?:

ALZHEIMER’S DISEASE? The most common form of dementia. This incurable, degenerative, and terminal disease was first described by German psychiatrist and neuropathologist Alois Alzheimer in 1906 and was named after him. Most often, it is diagnosed in people over 65 years of age, although the less-prevalent early-onset Alzheimer's can occur much earlier. In 2006, there were 26.6 million sufferers worldwide. Alzheimer's is predicted to affect 1 in 85 people globally by 2050.

DEMENTIA:

DEMENTIA From Latin, originally meaning "madness", from de- "without" + ment , the root of mens "mind“ Serious loss of cognitive ability in a previously unimpaired person, beyond what might be expected from normal aging. The first signs of dementia are short-term memory loss.

SIGNS OF DEMENTIA:

SIGNS OF DEMENTIA Loss of Memory: Forgetting some recent incidents and inability to recall information. Disorientation: People forget their familiar surroundings, neighborhood, wondering how they got there and do not know how to get back home. Communicating: People suffering from dementia forget simple words and substitute some irrelevant words in their speech, thus making it difficult to understand for the listener. Abstract thinking: People suffering from dementia have trouble carrying out simple calculations such as adding numbers, multiplying, dividing, subtracting and sometimes even forget the purpose of numbers and calculation.

SIGNS OF DEMENTIA:

SIGNS OF DEMENTIA Poor or reduced judgment: People suffering with dementia have poor judgment and do not know how to react in emergencies. Performance of familiar tasks: People face difficulty in performing daily activities such as preparing a meal or coffee, operating an oven, making a telephone call, playing a game, etc. Mood or behavioral changes: People suffering from dementia exhibit rapid changes in moods such as a happy/joyous mood to tears or anger for no apparent reason. Dementia patients can also experience depression. Misplacing articles: People with dementia tend to misplace articles in unusual places, such as placing a wristwatch in a sugar bowl or a plastic container on a gas stove. Loss of initiative: People suffering from Alzheimer’s disease become passive. For example watching TV for longer duration, sleeping for longer hours and not performing normal activities. Change in personality: Dramatic changes in personality of people suffering from dementia are also observed.

CAUSE:

CAUSE Alzheimer's disease is characterised by loss of neurons and synapses in the cerebral cortex and certain subcortical regions.

CAUSE:

CAUSE Both amyloid plaques and neurofibrillary tangles are clearly visible by microscopy in brains of those afflicted by AD. Plaques are dense, mostly insoluble deposits of amyloid -beta peptide and cellular material outside and around neurons.

PROTEINS THAT POWER DOWN THE BRAIN:

PROTEINS THAT POWER DOWN THE BRAIN INJURY due to a virus Genetics Unknown

DESTRUCTION OF NEURONS:

DESTRUCTION OF NEURONS

REISHI AND OLD AGE:

REISHI AND OLD AGE This ancient mushroom has been recommended in the past for older people and was said to help improve memory, concentration and cognitive functions. 靈芝

REISHI AND BETA-AMYLOIDS:

REISHI AND BETA-AMYLOIDS It was recently reported that beta- amyloid ( Abeta ) could cause synaptic dysfunction and contribute to AD pathology. In this study, the researchers reported: that water extract of G. lucidum significantly decreased Abeta -induced synaptotoxicity by preserving the synaptic density protein , SYNAPTOPHYSIN . That G. lucidum extract blocked the Abeta -triggered activities in a dose-dependent manner. That further damage to the neurons were prevented.

REISHI MAY PREVENT AD:

REISHI MAY PREVENT AD CONCLUSION: The results prove a hypothesis that anti-aging G. lucidum can prevent harmful effects of the exterminating toxin Abeta in AD. Antagonizing beta- amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum . Lai CS, Yu MS, Yuen WH, So KF, Zee SY, Chang RC, Laboratory of Neurodegenerative Disease, Department of Anatomy, The University of Hong Kong, Pokfulam , Hong Kong., Brain Res. 2008 Jan 23;1190:215-24. Epub 2007 Nov 13.

STUDY DONE ON MICE:

STUDY DONE ON MICE The aim of this study was to investigate if preadministration with Ganoderma lucidum spore (GLS) could (1) alleviate oxidative stress and mitochondrial dysfunction in rat hippocampus of intracerebroventricular (ICV) injection of streptozotocin (STZ), (2) protect neurons from apoptosis, and (3) improve cognitive dysfunction. Neuroprotective effect of preadministration with Ganoderma lucidum spore on rat hippocampus ., Zhou Y, Qu ZQ, Zeng YS, Lin YK, Li Y, Chung P, Wong R, Hägg U, Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China., Exp Toxicol Pathol . 2011 Jan 15

WITH THE DRUG ONLY…:

WITH THE DRUG ONLY… The results showed that ICV STZ model rats exhibited: a significant increase of malondialdehyde (MDA) a significant decrease of glutathione reductase (GR) and reduced glutathione (GSH), ATP and CytOx , accompanied with marked impairments in spatial learning and memory, and severe damage of hippocampal neuron

BUT THOSE WITH GLS…:

BUT THOSE WITH GLS… Preadministration with GLS at dose of 8.0g/kg in ICV STZ rats significantly reversed these abnormalities. In conclusion, preadministration with GLS might protect hippocampus from oxidative impairment and energy metabolism disturbance of ICV STZ. This may also provide useful information for future research on the pathogenesis and prevention of Alzheimer's disease (AD).

Slide 16:

Reishi available ONLINE Do it your own. More expensive More work

RED REISHI:

RED REISHI RED REISHI ADVANTAGES Extracted from the fruit body and spores Manufactured in an FDA approved facility in California Readily available One month supply $ 38 per bottle

Prepared by; Gene JM Dillague, MD Mighty Dove Global Chief Science Officer:

Prepared by; Gene JM Dillague, MD Mighty Dove Global Chief Science Officer www.myredreishi.com For your questions: dr.gene@mightydove.com

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