SELF EMULSIFYING DRUG DELIVERY SYSTEMS

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Self -emulsifying drug delivery systems (sedds) . Presented By :- Mr. Mayur Ravindra Patil . Sem-1(pharmaceutics) First Year M. Pharmacy R.G.SAPKAL COLLEGE OF PHARMACY, ANJANERI,NASHIK. 1

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OILS SURFACTANT CO- SURFACTANT DRUG DEFINITION OF SEDDS:- Combination Of All These Makes SEDDS. 2

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Definition. 3

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INTRODUCTION. 4

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NEED FOR SEDDS. 5

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HOW SEDDDS ACTS IN BODY?? 6

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FORMULATION CONSIDERATIONS. The S elf - E mulsification P rocess I s S pecific T o T he-

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EXCEPIENTS USED IN SEDDS. 1.Oils:- 8

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2.surfactants. 10

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2.co-surfactants.

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MECHANISM OF SELF-EMULSIFICATION.

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Δ G= Σ N π r² σ

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DIFFERENCE BETWEEN SEDDS AND SMEDDS. 1. HIGHER SURFACTANT AND CO-SURFACTANT /OIL RATIO:- SEDDS SMEDDS 17

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2.GLOBULE SIZE. SEDDS SMEDDS 100-300 nm <50 nm 40-80% <20% 3.Concentration of oil. 18

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TYPES OF S-SEDDS. CAPSULES TABLETS PELLETS POWDERS IMPLANTS SOLID DISPERSIONS SELF-EMULSIFYING DOSAGE FORMS. 19

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SOLID SEDDS Combines advantages of lipid based drug delivery systems with that of solid dosage form. Overcomes shortcomings of liquid formulations. Eg.SE Tablets of Diclofenac, Indomethacin etc. 20 advantages of s-seeds.

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DRUG. TRADE NAME/ COMPANY. TYPE OF FORMULATION. INDICATION. Cyclosporin A Neoral,Sandimmune (Novartis) Soft gelatin capsule Immuno-suppressant Ritonavir Norvir(Abbott) Soft gelatin capsule HIV Antiviral Sanquinavir Fortovase(Roche) Soft gelatin capsule HIV Antiviral Valproic acid Convulex (Pharmacia) Soft gelatin capsule Anti-epileptic MARKETED ORAL SOLID SEDDS.

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EVALUATION parameters of seeds.

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23

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APPLICATIONS. 24

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CONCLUSION. 25

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References. 28

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