Lecture14

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Interaction of cells with the environment Unit Outline: What is outside the cell and how do cells communicate with what’s “out there”? How do cells interact with their external environment? How do cells interact with each other?

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Extracellular space

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Extracellular space basal surface of ectodermal cell of chick embryo apical surface of epithelial cell from intestinal lining

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Extracellular matrix epidermis pulled away from basement membrane basement membrane between blood vessels of glomerus and renal tubules collagen

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Extracellular matrix

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Extracellular matrix Proteins of ECM - collagen

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Extracellular matrix Proteins of ECM - proteoglycans

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Extracellular matrix Proteins of ECM - fibronectin

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Extracellular matrix Proteins of ECM - laminin collagen laminin

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Interaction of cells with ECM inactive INTEGRINS

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Interaction of cells with ECM INTEGRINS functions of outside-in signals differentiation motility growth survival ligands have RGD motif

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Interaction of cells with ECM FOCAL ADHESIONS FA

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Interaction of cells with ECM FOCAL ADHESIONS

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Interaction of cells with ECM HEMIDESMOSOMES

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Interaction of cells with ECM

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Interaction of cells with cells CELL ADHESION MOLECULES

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Interaction of cells with cells CELL ADHESION MOLECULES

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Interaction of cells with cells CELL ADHESION MOLECULES

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Interaction of cells with ECM and other cells CELL ADHESION MOLECULES VS ECM ATTACHMENT MOLECULES

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vocabulary extracellular space extracellular matrix basement membrane glycocalyx collagen fibronectin proteoglycan GAG chains laminin inside-out signaling outside-in signaling focal adhesion focal adhesion kinase (FAK) actin keratin talin vinculin actinin hemidesmosome cell adhesion molecule selectin lectin Immunoglobulin superfamily cadherin tight junction adherins junction desmosome gap junction

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Extracellular Matrix Unit Learning Goals: the extracellular space: discuss the concept that the physical interactions between cells and their extracellular environment is highly specific as a result of molecular interactions between molecules on the cell with molecules in the matrix between cells and molecules on neighboring cells describe the molecular components of the extracellular matrix (ECM) and discuss the cellular processes regulated by interactions between cells and their extracellular environment

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interaction of cells with ECM: compare the structure, function and signaling activity of integrins and “true” ECM proteins like collagen, laminin, and proteoglycans comapre the structure and functions of molecular structures formed at the site of attachment of cells to an artificial substrate (focal adhesion) and to the basement membrane (hemidesmosome)

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interaction of cells with other cells: describe the general class of proteins mediating interactions between cells (cell adhesion molecules) using specific examples compare the functions of cell adhesion molecules and extracellular matrix attachment molecules discuss why insoluble solutes, whch cannot freely diffuse through the plasma membrane, also cannot pass freely between cells of an epithelial layer, and what would happen to tissues of they could

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d. compare tight junctions, adherins junctions, desmosomes , and gap junctions in terms of structure, function and the type of cells in which they are found e. draw, in cross section, two neighboring epithelial cells and illustrate the relative location and general structure of adherins junctions, desmosomes, tight junctions and gap junctions

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