Actinomyces & Nocardia : Actinomyces & Nocardia
Actinomyces : Actinomyces A.israelii, A.naeslundii; Gram positive; sulfur granule; Related to decay tooth and peridentitis
ACTINOMYCES: ACTINOMYCES Anaerobic, filamentous, gram positive bacillus Exhibit true branching “ Mykes ” – Greek for “ fungus ” Thought by early microbiologist to be fungi because of: Morphology Disease they cause
Clinical specimens:Actinomycosis-pus: Clinical specimens:Actinomycosis-pus
ACTINOMYCOSIS: ACTINOMYCOSIS Not highly virulent (Opportunist) Component of Oral Flora Periodontal pockets Dental plaque Tonsilar crypts Take advantage of injury to penetrate mucosal barriers Coincident infection Trauma Surgery
Actinomycosis: Actinomycosis A chronic suppurative and granulomatous 肉芽肿 disease of the cervico-facial, thoracic or abdominal areas
ACTINOMYCOSIS: ACTINOMYCOSIS Form indurated masses with fibrous walls and central loculations with pus Pus contains "Sulfur Granules" Gritty, yellow white Average diameter - 2mm Composed of mineralized “ mycelial ” mass Chronic infection Form burrowing sinus tracts to skin or mucus membranes Discharge purulent material
Actinomycosis - sulfur granule: Actinomycosis - sulfur granule
Pulmonary Actinomycosis: Pulmonary Actinomycosis 15% of cases Aspiration of organism from the oropaharynx Slowly progressive process involving lung and pleura May be mistaken for malignancy Chest pain, fever, wgt loss and hemoptysis
Mycetoma (足菌病）: Mycetoma ( 足菌病） Streptomyces species?
Nocardiosis: Nocardiosis Subcutaneous infections, pulmonary infections, and brain abscesses N. asteroides; N. brasiliensis
Lab. Diagnosis: Lab. Diagnosis Clinical Specimens:Sputum,Pus,Biopsy tissue Sulfamethoxazole-Trimethoprim