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Bioreactors: An Artificial Life Support System:

Bioreactors: An Artificial Life Support System Presented by: MITESH SHRESTHA


Contents Introduction to Bioreactors Types of Bioreactor designs Conclusion


Bioreactors Any manufactured or engineered device or system that supports a biologically active environment

Types of Bioreactor designs:

Types of Bioreactor designs Stirred tank reactors Bubble-column reactors Air lift reactors Drum rotating reactors Immobilized plane cell reactors Membrane reactors

Stirred tank reactors:

Stirred tank reactors Air is dispersed by mechanical agitation.


Advantages Better control over the environment of the culture.


Disadvantages Can cause damage to the cells High energy demand Complexity in construction Difficult to scale up.

Bubble-column reactors:

Bubble-column reactors One of the simplest type of gas – liquid bioreactors.


Advantages Facilitates sterile operation Less damaging to shear-sensitive cells Scale up is relatively easy.


Disadvantages Undefined fluid flow pattern inside the reactor. Non-uniform mixing.

Air-lift reactors:

Air-lift reactors Works on draught tube principle.


Advantages Reasonable mixing with low shear Operating cost is low. Less contamination


Disadvantages Insufficient mixing at high cell densities .

Drum rotating reactors:

Drum rotating reactors Consists of horizontally rotating-drum on rollers connected to a motor.


Advantages High oxygen transfer. Good mixing Facilitated better growth and impart less hydrodynamic stress.


Disadvantages Difficult to scale up.

Immobilized plane cell reactors:

Immobilized plane cell reactors Immobilization of plant cell into a suitable carriers. Either in natural (alginate, agar) or synthetic (polyacrylamide)

Membrane reactors:

Membrane reactors Cells are separated from growth medium by membrane


Advantages Environment is more easily controlled Better control over cell density.

PowerPoint Presentation:

Reactor type Oxygen transfer Hydrodynamic stress Mixing Scale up limitations Stirred-tank High Highly destructive Completely uniform Difficult Cell death; contamination due to moving parts ST-low agitation and modified impeller Medium Low Reasonably uniform Difficult Insufficient mixing at very high cell densities Bubble-column Medium Low Non-uniform Easy Dead zones; settling of cells due to poor mixing Air-lift High Low Uniform Easy Dead zones at high cell densities Rotating-drum High Low Uniform Difficult Non-uniform mixing at very large scale.


Conclusion Hence, with the help of different types of bioreactors, commercial production of secondary metabolites is not only possible but also profitable.

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