ocular drug delivery system

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In this presentation we study regarding ocular drug delivery system advantages and different advanced formulations using currently.

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Presentation Transcript

Ocular Drug Delivery System :

Ocular Drug Delivery System Presented by : P.SURESH 08M71R0051 UNDER THE GUIDANCE OF : B.ADINARAYANA M.SC(PHD)

CONTENTS :- :

CONTENTS :- Introduction Anatomy Of Eye Barriers In Ocular Absorption Ocular Absorption Use of Mucoadhesives in Ocular Drug Delivery Nanoparticulate Dug Delivery Ocular Inserts Liposome's In Ocular Drug Delivery Future trends Conclusion References

INTRODUCTION :-:

INTRODUCTION :- A drug delivery to circumvent ailments of eye. A challenge to formulator is to avoid protective barrier of eye Importance of cornea. Conventional ocular drug delivery system Need of a successful design

Slide 4:

OCULAR ANATOMY AND PHYSIOLOGY

Human eye consist of :- :

Human eye consist of :-

Mechanism Of Ocular Absorption:

Mechanism Of Ocular Absorption

General Pathway For Ocular Absorption:

General Pathway For Ocular Absorption

Role Of Polymer In ODDS. :

Role Of Polymer In ODDS . Solution Viscosity : Solution Drainage. Polymer Mucoadhesive Vehicle: Retained in the eye due to non-covalent bonding between with conjuctival mucine. Mucine is capable of picking of 40-80 times of weight of water. Factors Affecting Intraocular Bioavailability: 1. Inflow & Outflow of Lacrimal fluids. 2. Efficient naso-lacrimal drainage. 3. Interaction of drug with proteins of Lacrimal fluid. 4. Dilution with tears.

Classification Of Ophthalmic Dosage Form: :

Classification Of Ophthalmic Dosage Form:

Ocular indication of controlled-release systems:

Ocular indication of controlled-release systems Indication Drug & Disease 1. Short, topical ocular half-life Heparin for Ligneous disease 2. Small, topical ocular, therapeutic index Pilocarpine for chronic open-angle Glaucoma 3. Systemic side effects Timolol for Glaucoma and cyclosporin A for graft rejection 4. Need for combination therapy Cromoglycate and corticosteroid for Asthma and Allergies 5. Drug delivery over a prolonged period Acute corneal infections, Corneal Graft rejection episodes 6. Long-continued low dosage for therapy or prophylaxis Prevention of Corneal Graft Rejection or Herpetic diseases,

ADVANCED OCULAR DRUG DELIVERY SYSTEMS:

ADVANCED OCULAR DRUG DELIVERY SYSTEMS

Ocular Control Release System: Ophthalmic Inserts :

Ocular Control Release System: Ophthalmic Inserts Definition:-. Sterile preparations, with a thin, multilayered, drug-impregnated, solid or semisolid consistency devices placed into cul-de-sac or conjunctival sac. Desired Criteria For Control Release Ocular Inserts.

A) INSOLUBLE INSERTS::

A) INSOLUBLE INSERTS: 1.Ocusert: Developed by Alza Corporation, Oval flexible ocular insert, Release Rate:20-40mg/hr for 7day Consist of- Annular ring : Impregnated with Ti0 2 : For Visibility Part Material Drug Reservoir Pilocarpine Carrier material Alginic acid Rate controller Ethylene vinyl acetate copolymer Energy Source Conc. Of Pilocarpine Delivery Portal Copolymer membrane

2) Contact Lens ::

2) Contact Lens : Presoaked Hydrophilic lens. Drug Release : within 1 st 30 Min. Alternate approach : incorporate drug either as sol n or suspension of solid monomer mixture. Release rate is up to : 180 hr. 3) Diffusional Inserts : Central reservoir of drug enclosed in Semi permeable or micro porous membrane for diffusion of drug. Diffusion is controlled by Lacrimal Fluid penetrating through it. It prevents continues decrease in release rate due to barrier. Release follows : Zero Order Kinetics.

B)BIO Erodible Inserts ::

B)BIO Erodible Inserts : 1.Lacrisert: Sterile, Rod Shaped device. Composition: HPC without preservative. Weight:5mg, Dimension:Diameter:12.5mm, Length:3.5mm Use:-Dry eye treatment, Keratitis Sica. 2)Minidisc: It is made up of counter disc with Convex front & Concave back surface in contact with eye ball. 4-5mm in diameter. Composition : Silicon based pre polymer. Hydrophilic or Hydrophobic. Drug release from 170 hr.

Slide 17:

C.SOLUBLE INSERTS: SODI: Soluble Ocular Drug Insert. Small water soluble developed for Cosmonauts who could not use their eye drop in liquid condition. Composition : Acryl amide, Vinyl Pyrolidone, Ethylacrylate. Weight 15-16 mg. In 10-15 sec Softens; In 10-15 min. turns in Viscous Liquids; After 30-60min. Becomes Polymeric Solution. Advantages of SODI : Single SODI application :replaces 4-12 eye drops Instillation, or 3-6 application of Ointments. Once a day treatment of Glaucoma & Trachoma.

Nanoparticle::

Nanoparticle:

Liposome's::

Liposome's:

Advances in ocular drug delivery:

Advances in ocular drug delivery 1. Ophthalmic gel for pilocarpine Poloxamer 407 (low viscosity, optical clarity, mucomimetic property) 2. Ophthalmic prodrug Dipivalyl epinephrine ( Dipivefrin ) Lipophilic  increase in corneal absorption Esterase within cornea and aqueous humor 3. Continuous delivery system based upon the osmotic property Thin flat layer, contoured three-dimensional unit Conform to the space of the upper cul-de-sac Delivery of diethyl carbamazine in ocular onchocerciasis

4.Gel delivery system:

4.Gel delivery system Biodegradable polyisobutyl-cyano acrylate (PIBCA) colloidal particulate system of pilocarpine to incorporate it into a Pluronic F127 (PF 127)-based gel delivery system. 5)Mucoadhesive Polymer. mucoadhesive polymer, the tamarind seed polysaccharide, as a delivery system for the ocular administration of hydrophilic and hydrophobic antibiotics.

FUTURE TRENDS:

FUTURE TRENDS The sustained and controlled release technologies are being proposed and the possible benefits of using liposome's, nanoparticles and inserts will be at store in future. Targeted drug delivery with modifications of conventional, advanced and novel ocular drug deliveries has potential as future drug delivery for eye. It is possible to the give effective ocular drug delivery to any part of the eye.

CONCLUSION:

CONCLUSION Very few advanced ocular drug delivery systems have been commercialized. The performance of these new products, however, is still far from being perfect. Major improvements are required in each of the technologies discussed in this study. More clinical studies are necessary to provide further information and insights into these advanced ocular drug delivery systems .

Reference::

Reference: N.K.Jain, Advances in Controlled & Novel Drug Delivery, CBS Publication, & distributor, New Delhi, pg No.219-223. Remington & Gennaro ; The Science & Practice Of Pharmacy. Mack Publication Company. Easton, Pennsylvania. Pg. No. 1563-1567. Web Sites: www.vision-care-guide.com www.google /images/eye/anatomy& physiology

Thank You....! :

Thank You....! The eyes are the mirror of the soul… Take care of your eyes with gentleness…