LACTOLINE

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Dr.Kedar Karki WELCOME LACTOLINE:A PROBIOTIC FOR POULTRY/LIVESTOCK

OVERVIEW : 

OVERVIEW Approximately 90 % of the intestinal flora in birds is composed of facultative lactic acid producing bacteria such as lactobacilli, Enterococcus and some strictly anaerobic bacteria. The remaining 10 % are such as Escherichia coli, clostridium, Staphylococcus, Pseudomonas, and others. (FOX, 1988).

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Poultry grown in intensive production facilities are subjected to many additional types of stressors 1.Transportation from the hatchery facility to the farm 2. High production density and overpopulation 3. Vaccination programs 4. Variations in environmental temperatures 5. Pathogenic, viral, bacterial and toxicogenic field challenges

Stressors have a detrimental effect in the normal balance of the intestinal flora resulting in a decreased immune response, (JIN et al., 1997). : 

Stressors have a detrimental effect in the normal balance of the intestinal flora resulting in a decreased immune response, (JIN et al., 1997). Also other important factors are affected such as: Increased intestinal infections due to secretion of toxins, Reduced rate of growth, Increased feed conversion, Reduced egg production, Lowered fertility, Diminished hatchability,

Qualitative factors are affected as well such as the carcass quality. (bruising as seen here>>>) : 

Qualitative factors are affected as well such as the carcass quality. (bruising as seen here>>>) These problems are further exacerbated by the likely increase of opportunistic pathogenic bacteria, resultant diarrheas and anemic conditions. (FOX, 1988). Research involving plausible solutions to this problem has recently focused attention on the natural defense mechanisms that are normally available to poultry and livestock in general in their own intestinal portal tissue.

The use of probiotics in poultry operations is gaining momentum by the day. The reason and even necessity for this is that probiotics offer a wide array of advantages that poultry operators can not afford to overlook : 

The use of probiotics in poultry operations is gaining momentum by the day. The reason and even necessity for this is that probiotics offer a wide array of advantages that poultry operators can not afford to overlook Probiotic seeks to restore the negative effects produced via antibiotic treatments, degrade many deleterious types of mycotoxins and bacterial toxins, and to eventually replace the use of antibiotics altogether.

A probiotic should afford the following characteristics : 

A probiotic should afford the following characteristics 1. That it contribute probiotics which are analogous to the native micro-flora of the organism. 2. That it not produce any deleterious effects nor originate from toxic substances. 3. That the micro-organisms in the probiotic have the ability to adhere easily to the intestinal wall and multiply rapidly.

WHAT IS LACTOLINE : 

WHAT IS LACTOLINE A unique combination of highly effective live colony forming microorganisms consisting of 150 X 106 CFM of: Saccharomyces Cerevisiae, Enterococcus faecium, Lactobacillus acidophilus, Lacobacillus casei, Lactobacillus plantarrum and Lactobacillus brevis placed in media consisting of dried brewers yeast which includes brewers’ grain (barly and wheat), oligosaccharides and cell wall extract. A 100 % natural probiotic. A 100 % natural toxin binder

Why use Lactoline ? : 

Why use Lactoline ? ⊳ Producers commonly feed low levels of antibiotics for growth promotion ⊳ The feed industry is looking for alternatives to this practice because many pathogenic microorganisms are becoming resistant antibiotics ⊳ Lactoline offers a viable, effective and natural alternative to the widespread use of antibiotics.

What does Lactoline do? : 

What does Lactoline do? Provides a source of live, naturally occurring microorganisms as an aid in the amelioration of mycotoxicoses. Supplements desirable organisms to newborn animals during incidences of scours at weaning and other diet changes. Maintains a healthy microbial balance in animals. Helps maintain appetite. Used as part of a health maintenance program.

I. How does Lctoline work? : 

I. How does Lctoline work? Beneficial bacteria produce a variety of organic acids and other compounds that inhibit the growth of E.coli and other intestinal pathogens. Organic acids also can serve as energy sources to the animal or other beneficial bacteria. Lactic acid bacteria produce antimicrobials that inhibit intestinal pathogens. Beneficial bacteria deconjugate bile salts inhibiting enteric pathogens.

II. How does Lactoline work? : 

II. How does Lactoline work? Lactic acid bacteria out-compete pathogens for nutrients in the gut.( figure 1)

III. How does Lactoline work? : 

III. How does Lactoline work? Animals fed lactic acid-producing bacteria have an increase of activity in their immune system, improving the animal’s resistance to bacterial infections. NUTRIENTS Lactoline

IV. How does Lactoline work? : 

IV. How does Lactoline work? Beneficial bacteria produce enzymes which breakdown feedstuffs into smaller, more easily absorbed nutrients. Lactic acid bacteria reduce the level of amines in the gut which are toxic.

V. How does LACTOLINE work? : 

V. How does LACTOLINE work? AGAINST MYCOTOXINS Bio-Transformation Bio-Agglutination Bio- Degradation

Bio- Transformation : 

Bio- Transformation Bio-Transformation is one of four processes involved in toxicokinetics

VI. How does LACTOLINE work? : 

VI. How does LACTOLINE work? What is Toxicokinetics? Toxicokinetics is essentially the study of "how a toxic substance such as a mycotoxin gets into a given physiological organism such as abody or a multicellular biological system and what happens to it in that system". It is widely known that many pathogenic bacteria have become immune to many types of antibiotics which are in many instances mycotoxins. Mycolactor has specially selected strains of Lactobacillus, E. faecium, S. cerevisiae and other technologies that Bio-Transform, (detoxify) mycotoxins.

TOXICOKINETICS : 

TOXICOKINETICS

VI. How does LACTOLINE work? : 

VI. How does LACTOLINE work? Bio- Transformation Two substances with equal toxicity and absorption may differ in hazard depending on the nature of their biotransformation.  A substance biotransformed into a more toxic metabolite (bioactivated) is a greater hazard than a substance that is biotransformed into a less toxic or even non-toxic metabolite (detoxified).

Bio- Agglutination : 

Bio- Agglutination The process by which toxic or pathogenic substances “stick” to long chain olygosacharide molecules Bio- Degradation Degradation via enzymatic activity

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LACTOLINE

BENEFITS EXPLANATION : 

Metabolizes substrates into sugars, vitamins, amino acids & proteins making them unavailable to pathogens. BENEFITS EXPLANATION Overpowers & outcompetes pathogenic bacteria. Produces lactic acid decreasing intestinal pH, inhibiting pathogenic bacteria growth. Metabolizes bacteriocines which work against pathogenic bacteria. Increases enzymatic activity & absorption in the intestinal tract. Produces vitamins & enzymes that degrade mycotoxins.

BENEFITS EXPLANATION, cont. : 

BENEFITS EXPLANATION, cont. Promotes healthy equilibrium of the intestinal flora & resulting benefits to the animal. Produces lactic acid which elicits an Immune reponse & the production of antibodies & increased phagocytic activity. Physically precludes the possibility for other harmful bacteria to occupy the same space.

COMPARATIVE CHART : 

COMPARATIVE CHART

COMPARATIVE CHART : 

COMPARATIVE CHART

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The End … for now … want to thank you for taking time to view this LACTOLINE presentation