logging in or signing up Ocular insert as a drug carrier system kamalsrathore Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 3921 Category: Science & Tech.. License: All Rights Reserved Like it (7) Dislike it (0) Added: August 12, 2009 This Presentation is Public Favorites: 4 Presentation Description Eye anatomy, various eye drug delivery systems, special emphasis on ocular inserts are given Comments Posting comment... By: rekhadevi (8 month(s) ago) plz send ur ppt , i m lecturer in tirupati pharmacy college. Saving..... Post Reply Close Saving..... Edit Comment Close By: ramprasadbattala (9 month(s) ago) your ppt is very helpful to me sir , So plz forward one copy to my mail, ramprasadbattala@yahoo.com, I'll be very thankfull to you sir. Saving..... Post Reply Close Saving..... Edit Comment Close By: pandusrujan (10 month(s) ago) pls help me in downloading it Saving..... Post Reply Close Saving..... Edit Comment Close By: bajia8 (10 month(s) ago) your ppt is very helpful to me sir , So plz forward one copy to bajia8@gmail.com, I'll be very thankfull to you sir. Saving..... Post Reply Close Saving..... Edit Comment Close By: deepika12345 (12 month(s) ago) sir i need it plz send this ppt to me Saving..... Post Reply Close Saving..... Edit Comment Close loading.... See all Premium member Presentation Transcript Ocular Insert as a Drug Carrier System : Ocular Insert as a Drug Carrier System *Rathore K.S., Nema R.K. BN Girls College of Pharmacy, Udaipur-Raj. Rishiraj college of Pharmacy, Indore, MP July25, 2009 National Conference on Changing Trends in Pharmacy Education and Research, Apex IPS, Jaipur Slide 2: Slide 3: The ophthalmic preparations are available as sterile, buffered, isotonic solution. Several types of dosage forms are applied as the delivery system for the ocular delivery of drugs. The most prescribed dosage form is the eye drop solution as drops are easier to administer. Suspensions, gelled systems, ointment are also used for prolonged therapeutic action. But these are primordial and inefficient * * * * Nanosphere- corneal contact lens Topical Ophthalmic Drug Delivery Device™ -ocular inserts Slide 4: Characteristics of ophthalmic preparations Should be- non-irritating to the ocular tissue. homogenous i.e, particles uniformly dispersed, smooth & free from lumps or agglomerates. Relatively non-greasy. Should not cause blurred vision. Should not cause intolerable foreign body sensation. Sterile & adequately preserved. Physically & chemically stable. Efficacious. Slide 5: Current ophthalmic drug delivery: Drops (95%+ of $8-12 billion mkt), ocular insert, gels and ointments Advantages of drops: Established, inexpensive manufacturing, Accepted standard of care Disadvantages: Variable, messy and difficult dosing, compliance issues, Short residence time, dilution and washout, require high drug concentration, systemic side-effects Slide 6: Problems with conventional ophthalmic dosage forms Drainage of the instilled solution; Lacrimation and tear turnover; Metabolism; Tear evaporation; Non-productive absorption/ adsorption; Limited corneal area and poor corneal permeability; and Binding of the lachrymal proteins. Slide 7: The following recent trends are in vogue: Polymer based delivery plans Mucoadhesive dosage forms Ocular Inserts Collagen shields Drug presoaked hydrogel type contact lens and pledgets- Ocufit®, Minidisc®, SODI®,NODS®, Lacrisert® etc. Ocular Iontophoresis Phase Transition systems Microspheres and Nanoparticles Chemical delivery systems vesicular systems. Slide 8: New ocular drug delivery systems: Using eye drops to administer drugs needs frequent application. Prolonged drug release can be achieved using ophthalmic inserts, solid devices placed in the eye, but the inserts must then be removed when they are no longer needed. Ocuserts are the new drug delivery systems which are designed in such a way that they release the drug at predetermined and predictable rates thus eliminating the frequent administration of the drug. The systems generally include controlled, delayed and or sustained release bioerodible implantable elements having multiple layers of different materials and/or different concentrations of materials. The elements generally include an inner layer, or core, including a therapeutic agent, and one or more outer layers made of polymeric materials, for example substantially pure polymeric materials. The core may include a polymeric material combined with an active agent beneficial in treating a condition of an eye. e.g. the pilocarpine inserts used in glaucoma therapy PILOCAR-20®, PILOCAR-40®. CLASSIFICATION OF OPHTHALMIC INSERTS : CLASSIFICATION OF OPHTHALMIC INSERTS Slide 10: Slide 11: Advantages with ocuserts such as: Accurate dosing Capacity to provide at constant rate and prolong drug release thus a better efficacy. Increasing contact time and thus improving bioavailability. Possible reduction of systemic absorption and thus reduced systemic adverse effects. Slide 12: Reduced frequency of administrations and thus better patient compliance with lower incidence of visual side effects. Administration of an accurate in the eye and thus a better therapy Possibility of targeting internal ocular tissues through non-corneal conjuctival-scleral penetration routes; and Increased shelf life with respect to eye-drops due to the absence of water. Slide 13: Advantage of inserts as dosage form Ease of handling and insertion Lack of expulsion during wear Reproducibility of release kinetics Applicability to variety of drugs Non-interference with vision and oxygen permeability. Sterility. Stability. Ease of manufacture Slide 14: Insoluble ophthalmic inserts Slide 15: Slide 16: Slide 17: Ocular inserts are prospectives for future In common disorders Astigmatism Glaucoma Myopia Retinitis pigmentosa Blurred vision Hyperopia Blepharitis Corneal ulcer Photokeratitis Cataract etc. Slide 18: “Sight is the sense which is more valuable than all the rest.” So Take care of Eyes!!! Slide 19: Thank you all. You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
Ocular insert as a drug carrier system kamalsrathore Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 3921 Category: Science & Tech.. License: All Rights Reserved Like it (7) Dislike it (0) Added: August 12, 2009 This Presentation is Public Favorites: 4 Presentation Description Eye anatomy, various eye drug delivery systems, special emphasis on ocular inserts are given Comments Posting comment... By: rekhadevi (8 month(s) ago) plz send ur ppt , i m lecturer in tirupati pharmacy college. Saving..... Post Reply Close Saving..... Edit Comment Close By: ramprasadbattala (9 month(s) ago) your ppt is very helpful to me sir , So plz forward one copy to my mail, ramprasadbattala@yahoo.com, I'll be very thankfull to you sir. Saving..... Post Reply Close Saving..... Edit Comment Close By: pandusrujan (10 month(s) ago) pls help me in downloading it Saving..... Post Reply Close Saving..... Edit Comment Close By: bajia8 (10 month(s) ago) your ppt is very helpful to me sir , So plz forward one copy to bajia8@gmail.com, I'll be very thankfull to you sir. Saving..... Post Reply Close Saving..... Edit Comment Close By: deepika12345 (12 month(s) ago) sir i need it plz send this ppt to me Saving..... Post Reply Close Saving..... Edit Comment Close loading.... See all Premium member Presentation Transcript Ocular Insert as a Drug Carrier System : Ocular Insert as a Drug Carrier System *Rathore K.S., Nema R.K. BN Girls College of Pharmacy, Udaipur-Raj. Rishiraj college of Pharmacy, Indore, MP July25, 2009 National Conference on Changing Trends in Pharmacy Education and Research, Apex IPS, Jaipur Slide 2: Slide 3: The ophthalmic preparations are available as sterile, buffered, isotonic solution. Several types of dosage forms are applied as the delivery system for the ocular delivery of drugs. The most prescribed dosage form is the eye drop solution as drops are easier to administer. Suspensions, gelled systems, ointment are also used for prolonged therapeutic action. But these are primordial and inefficient * * * * Nanosphere- corneal contact lens Topical Ophthalmic Drug Delivery Device™ -ocular inserts Slide 4: Characteristics of ophthalmic preparations Should be- non-irritating to the ocular tissue. homogenous i.e, particles uniformly dispersed, smooth & free from lumps or agglomerates. Relatively non-greasy. Should not cause blurred vision. Should not cause intolerable foreign body sensation. Sterile & adequately preserved. Physically & chemically stable. Efficacious. Slide 5: Current ophthalmic drug delivery: Drops (95%+ of $8-12 billion mkt), ocular insert, gels and ointments Advantages of drops: Established, inexpensive manufacturing, Accepted standard of care Disadvantages: Variable, messy and difficult dosing, compliance issues, Short residence time, dilution and washout, require high drug concentration, systemic side-effects Slide 6: Problems with conventional ophthalmic dosage forms Drainage of the instilled solution; Lacrimation and tear turnover; Metabolism; Tear evaporation; Non-productive absorption/ adsorption; Limited corneal area and poor corneal permeability; and Binding of the lachrymal proteins. Slide 7: The following recent trends are in vogue: Polymer based delivery plans Mucoadhesive dosage forms Ocular Inserts Collagen shields Drug presoaked hydrogel type contact lens and pledgets- Ocufit®, Minidisc®, SODI®,NODS®, Lacrisert® etc. Ocular Iontophoresis Phase Transition systems Microspheres and Nanoparticles Chemical delivery systems vesicular systems. Slide 8: New ocular drug delivery systems: Using eye drops to administer drugs needs frequent application. Prolonged drug release can be achieved using ophthalmic inserts, solid devices placed in the eye, but the inserts must then be removed when they are no longer needed. Ocuserts are the new drug delivery systems which are designed in such a way that they release the drug at predetermined and predictable rates thus eliminating the frequent administration of the drug. The systems generally include controlled, delayed and or sustained release bioerodible implantable elements having multiple layers of different materials and/or different concentrations of materials. The elements generally include an inner layer, or core, including a therapeutic agent, and one or more outer layers made of polymeric materials, for example substantially pure polymeric materials. The core may include a polymeric material combined with an active agent beneficial in treating a condition of an eye. e.g. the pilocarpine inserts used in glaucoma therapy PILOCAR-20®, PILOCAR-40®. CLASSIFICATION OF OPHTHALMIC INSERTS : CLASSIFICATION OF OPHTHALMIC INSERTS Slide 10: Slide 11: Advantages with ocuserts such as: Accurate dosing Capacity to provide at constant rate and prolong drug release thus a better efficacy. Increasing contact time and thus improving bioavailability. Possible reduction of systemic absorption and thus reduced systemic adverse effects. Slide 12: Reduced frequency of administrations and thus better patient compliance with lower incidence of visual side effects. Administration of an accurate in the eye and thus a better therapy Possibility of targeting internal ocular tissues through non-corneal conjuctival-scleral penetration routes; and Increased shelf life with respect to eye-drops due to the absence of water. Slide 13: Advantage of inserts as dosage form Ease of handling and insertion Lack of expulsion during wear Reproducibility of release kinetics Applicability to variety of drugs Non-interference with vision and oxygen permeability. Sterility. Stability. Ease of manufacture Slide 14: Insoluble ophthalmic inserts Slide 15: Slide 16: Slide 17: Ocular inserts are prospectives for future In common disorders Astigmatism Glaucoma Myopia Retinitis pigmentosa Blurred vision Hyperopia Blepharitis Corneal ulcer Photokeratitis Cataract etc. Slide 18: “Sight is the sense which is more valuable than all the rest.” So Take care of Eyes!!! Slide 19: Thank you all.