TABLET factory layout

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JAVED SIDDIQUI, AMITY UNIVERSITY LUCKNOW SUBMIT TO: NIMISHA MAM

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FACTORY LAYOUT Presented by: javed siddiqui Wasim Khan, Rubeena Khan, Richa Srivastava , M.Pharm 2 nd sem 1

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2 LAYOUT OF TABLET MANUFACTURING SECTION

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Purpose : To control cross contamination. Three types of layout- 1. Circular Flow 2. Parallel Flow 3. Crossover Traffic 3 TYPES OF TABLET MANUFACTURING LAYOUT

Circular flow: :

Circular flow: It consists of receiving , approved raw materials, components storage, and dispensing on one side , with manufacturing, quarantine, bulk stock, and packaging across a central corridor . Advantage: Since the flow is circular so it eliminates much of crossover traffic .

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centre warehouse::

centre warehouse: In this type the centre, warehouse area for raw materials, packaging components, and bulk stocks, with the manufacturing and packaging operations located at the outer perimeter. Advantage : Space conservation by virtue of having the supply areas close to the areas being supplied. Disadvantage : Chances of contamination or mix up b/c of crossover traffic pattern of material.

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MIXING,GRANULATION & DRYING AREA Powder mixer Mass mixer / Planetary mixer / Rapid mixer granulator . Granulators ( High shear granulator, chilsonator) Tray dryer/FBD Weighing Machines 9 TABLET GRANULATION

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Machines Digital Weighing balance Mixer Granulator Tray dryer Miller 10

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Machines (cont.) 11 Blender Tablet press Blistering Coating Packaging

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Granulation technology on large scale by various techniques

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13 TABLET GRANULATING AREA

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1-Tablet Compression Machine: Single punch/Multi-punch/ Rotatory punch & Die storage cabinet 2-Tablet Inspection Unit & belt 3-Dissolution Testing Apparatus 4-IPQC- instruments 14 TABLET COMPRESSION

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BOOTH-1 BOOTH-3 FOR ROTARY & PALLET FOR LARGER SINGLE PUNCH PRESSES PRESSES PRESS BOOTH-2 AREA FOR SINK & STORAGE FOR ROTARY & FOR DIES & PUNCHES & SINGLE PRESSES MACHINE TOOLING PALLET 15 TABLET COMPRESSING AREA PAPAP PPPPPPPPP P PP PP

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16 References Lachman L. The Theory and practice of industrial pharmacy. 3 rd Edition. Varghese publication house. www. authorstream.com www.scribd.com

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