aerosol packaging

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SEMINAR ON AEROSOL PACKAGING

AEROSOL PACKAGING:

AEROSOL PACKAGING Aerosol may be defined as disperse phase system in which very fine solid particles or liquid droplets get dispersed in the gas which acts as continuous phase. These are also called pressurised dosage form

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Advantages of Aerosol The medicament can be delivered directly to the affected area such as burnt skin and wound Absence of air prevents oxidation of the product. The hydrolysis of medicaments can be prevented. Drugs can be given by oral inhalation. The sterility of the products can be maintained.

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Disadvantage of Aerosol Aerosol are costly preparation. Some of the propellants are very toxics. The cooling effect of highly volatile propellants may cause discomfort on injured skin. Lot of difficulties are faced in aerosol formulation when the drug is not soluble in propellant.

CLASSIFICATION OF AEROSOL:

CLASSIFICATION OF AEROSOL Space sprays: These are finely divided sprays having particle size up to 50µ e.g. insecticides, disinfectants and room deodorizers. Surface coats: There are also sprays but disperse particles are coarse with size up to 200µ.They produces a wet coat when sprayed on a surface e.g. hair spray, personal deodorants, powder sprays and topical medicaments sprays. Foam: These are produced by rapid expansion of propellants through an emulsion. Hence the product comes in the form of a foam or froth e.g shaving cream and vaginal product.

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Packaging of Aerosols:- Cold-fill process:- This process is used to fill metered aerosol product using a fluorocarbon propellant. By lowering the temperature of a propellant below its boiling the propellant becomes liquid at atmospheric pressure. The active ingredient or concentrate and propellant are cooled to a low temperature of -30 0 to-40 0 F. The concentrate is generally cooled to below 0 in order to reduce loss of propellant during the filling operation.

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The chilled concentrate is poured into the chilled container and propellant is added sufficient the air present in the container. The valve is fitted on to the container which is placed into a water bath so that the contents are heated to 130 0 F (54 0 C) in order to check any leakage and strength of container. A dry ice-acetone bath is used to obtain the desired low temperature for laboratory scale preparation whereas refrigeration equipment is used for the large scale production of aerosols

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Pressure-fill process:- This process is used for filling aerosols containing hydrocarbon propellant. The product concentrate is placed into the container and the valve is sealed. The propellant is forced through the valve under pressure. After this the container is immersed in a water bath at 1300F (or 540 C) in order to check any leakage and strength of the container. It is essential that the air present in the container must be expelled before filling the contents into the aerosol container.

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Application of Aerosol Packaging:- They are used for spray bandages and for application of drugs meant for topical use. They are used for spray administration of drugs into various body cavities. They are used to spray cosmetic preparation such as perfumes. They are used to spray disinfectants, deodorizers and air sanitizers.

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REFERENECE PHARMACEUTICS [ I ] R.M.MEHTA PAGE NO: 85-88 THE THEORY AND PRACTICE OF INDUSTRIAL PHARMACY LEON LACHMAN HERBERT LIEBERMAN 2ND EDITION PAGE NO : 589- 612

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