REVERSIBLE CELL INJURY

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REVERSIBLE CELL INJURY:

REVERSIBLE CELL INJURY By Libason Hosea MD2 student Muhimbili university e mail: hlibason@gmail.com

REVERSIBLE CELL INJURY (non lethal cell injury):

Adaptive response to noxious stimuli or stress to a cell includes; -hypertrophy -hyperplasia - metaplasia -Atrophy If the stimulus persists or if it is severe from the beginning, Then what follows is cell injury REVERSIBLE CELL INJURY (non lethal cell injury)

Reversible cell injury:

Reversible cell injury injury follows after adaptive capability of the cell is exceeded and there is severe membrane damage and nuclear alteration. Reversible cell injury Irreversible cell injury

Causes of cell injury:

Causes of cell injury Hypoxia Ischemia Chemical agents eg reactive oxygen species Infectious agents Immunologic reaction eg.autoimmune disease Nutritional imbalances Genetic defects eg . Hbs causing premature death of RBCs Physical agents eg . Radiations, extrem temperatures, etc. Aging Nutritional imbalances ie . undernutrition eg kwarshiorkor and marasmus Overnutrition eg . Artherosclerosis

Morphologic alterations of cell injury:

Morphologic alterations of cell injury Cellular swelling Fatty change Other changes

Cellular swelling:

Cellular swelling Is the result of failure of energy dependent ion pumps in plasma membrane leading to inability to maintain ionic and fluid homeostasis Cellular swellings are difficult to see in light microscope Microscopic examination may reveal small clear vacuole within the cytoplasm These represents pinched off segment of ER

2.Fatty change:

2. Fatty change Occurs in hypoxic injury and various forms of toxic or metaplastic injury Manifested by appearance of large or small lipid vacuole in the cytoplasm Occur in cells involved and dependant on fat metabolism such as hepatocytes and myocardial cells Injured cells may show increased esinophilic staining which becomes much more pronounced with progression to necrosis

3.Other changes;:

3. Other changes ; Plasma cell membrane alterations Distortion of microvilli Mitochondrial changes such as mitochondrial swelling Dilatation of ER Nuclear alteratins Eosinophilia alterations

if the the stimuli persists :

if the the stimuli persists Irreversible cell injury Necrosis

Thank you:

reference:chapter 1, Robbins basic pathology 8 th ed Kumar et al Thank you