Introduction to Pharmaceutical Inorganic Chemistry

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Introduction to Key aspect of Inorganic Chemistry

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Mr. Hemant U. Chikhale Assistant Professor Department of Pharmaceutical Chemistry:

Mr. Hemant U. Chikhale Assistant Professor Department of Pharmaceutical Chemistry Introduction to Pharmaceutical inorganic chemistry Gokhale Education Society. Sir Dr. M. S. Gosavi College of Pharmaceutical Education and Research Nashik-05

Flow of Presentation: 1. Introduction to pharmaceutical inorganic chemistry, 2. Different Pharmacopoeia and contents of individual monographs. 3. Indian Pharmacopoeia – History and detail study of different volumes along with general notices, 4. New inclusion/exclusion of compound monograph.:

Flow of Presentation: 1. Introduction to pharmaceutical inorganic chemistry, 2. Different Pharmacopoeia and contents of individual monographs. 3. Indian Pharmacopoeia – History and detail study of different volumes along with general notices, 4. New inclusion/exclusion of compound monograph.

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INORGANIC CHEMISTRY: Chemistry Of Mineral Chemistry Of Non- Carbon Compound PHARMACY: Pharmacy is the science and technique of preparing and dispensing drugs. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. “PHARMACY” word come from “ PHARMAKON-(DRUG)” a greek word.

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History of Pharmacopoeia Pharmacopoeia: an official publication of respective country that deals with regulation of drug and its formulation for human use . United state Pharmacopoeia (USP) British Pharmacopoeia European Pharmacopoeia Japanese Pharmacopoeia Etc…. First pharmacopoeia- London pharmacopoeia (1618) Word wide accepted pharmacopoeia- British pharmacopoeia (1864) East India company- Bengal Pharmacopoeia and General Conspectus of Medicinal Plants (1844 ) Indian Pharmacopoeia (IP) is an official document meant for overall Quality Control and Assurance of Pharmaceutical products marketed in India by way of contributing on their safety, efficacy and affordability. IP contains a collection of authoritative procedures of analysis and specifications for Drugs. The IP, or any part of it, has got legal status under the Second Schedule of the Drugs & Cosmetics Act, 1940 and Rules 1945 there under . 1885 - British Pharmacopoeia was made official in India 1927 - A drug Enquiry Committee appointed by the government 1948 - After independence, the Indian Pharmacopoeia Committee was constituted for publication of IP as its main function.

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YEAR EDITION CHAIRMAN 1955 Supplement. 1960 FIRST Dr. B.N. GHOSH 1966 Supplement. 1975 SECOND Dr. B. MUKHARJI 1985 I st Supplement/addendum 1989 II nd Supplement/addendum 1991 THIRD Dr. NITYA ANAND 1996 III rd Supplement/addendum 2000 IV th Supplement/addendum 2002 FOURTH Dr. NITYA ANAND 2007 FIFTH Dr. NITYA ANAND 2010 SIXTH Dr. NITYA ANAND 2014 V th Supplement/addendum 2015 SEVENTH Dr. G.N.SINGH

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Salient features: INDIAN PHARMACOPOEIA-2014 IP 2014 is effective from 1 st January, 2014 Total monographs 2548 577 New Monographs included in this edition 19 New Radiopharmaceutical Monographs and 1 General chapter is first time being included in this edition.   Presented in 4 hard bound volumes with DVD    Veterinary products monographs are the integral part of this edition  Use of chromatographic methods has been greatly extended   Classical chemicals tests for identification of an article have been almost eliminated and more specific IP and UV Spectrophotometer tests have been introduced Test for pyrogen virtually eliminated   Obsolete monographs have been omitted    More herbal drugs monographs has been added    Contains several new monographs not included in any other major pharmacopoeias of the world

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Monograph: Written document that gives information of drug in relation to… 1. Physicochemical test.. (Nature, Color, Description, Chemical name, Chemical formula, Category, Dose etc) 2. Identification test (Limits for- Cl, S, Ar, Pb, Heavy metal, TLC and HPLC methods, Assay) A monograph is a written document, or standard, that describes an item (e.g., a finished drug, a drug ingredient, or food chemical). A monograph published in any USP compendium (in a book, CD-ROM, or on line) provides: the name of a substance; its definition; package, storage, and labeling requirements; and information on tests needed to ensure the substance is of the appropriate strength, quality, and purity Physico -chemical parameter: Title: Indicate the official name of drug Chemical name: it include the IUPAC, CAS of drug Molecular formula: represents the element present in compound Molecular weight. Gives its weight Category : represents its pharmacological effect

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6 . Solubility: represents the standards for drug to be categories as follows 7. Storage: Specific direction given with temperature or without temperature.

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