logging in or signing up Capsules harish_pharma Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 9044 Category: Science & Tech.. License: All Rights Reserved Like it (4) Dislike it (0) Added: July 28, 2010 This Presentation is Public Favorites: 7 Presentation Description No description available. Comments Posting comment... By: nagesh4660 (26 month(s) ago) very nice ppt .sir klindly send it to my mail id firstname.lastname@example.org Saving..... Post Reply Close Saving..... Edit Comment Close By: faisalasif (26 month(s) ago) Thanks Saving..... Post Reply Close Saving..... 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These capsules are made up of gelatin blends, small amount of certified dyes, opaquants, plasticizers and preservatives. HARD GELATIN CAPSULE Slide 3: 3 Certified Dyes Colour approved by D & C act. Opacifiers Tio2 Plasticizers Sorbitol, Glycerin. Preservatives Propyl and Methyl Parabens GELATIN : 4 GELATIN Gelatin is heterogeneous product derived by hydrolytic extraction of animal's collagen. The sources of gelatins including animal bones, hide portions and frozen pork skin. TYPES OF GELATIN Type A Type B There are two basic types of gelatin : 5 There are two basic types of gelatin TYPE A Derived from acid treated precursor that exhibits an iso electric point at pH-9. It is manufactured mainly from pork skin. TYPE B Derived from alkali treated precursor that exhibits an iso electric point at pH-4.7. It is manufactured mainly from animal bones PARTS OF CAPSULE : PARTS OF CAPSULE 6 CAP BODY MANUFACTURE OF EMPTY GELATIN CAPSULES : 7 MANUFACTURE OF EMPTY GELATIN CAPSULES Steps involved in making empty gelatin capsules… Dipping Spinning Drying Stripping Trimming and Joining Polishing Slide 8: 8 Dipping : Pairs of the stainless steel pins are dipped into the dipping solution to simultaneously form the caps and bodies. The dipping solution is maintained at a temperature of about 500C in a heated, jacketed dipping pan. Spinning : The pins are rotated to distribute the gelatin over the pins uniformly and to avoid the formation of a bead at the capsule ends. Slide 9: 9 Drying : The gelatin is dried by a blast of cool air to form a hard shells. The pins are moved through a series of air drying kilns to remove water Stripping : A series of bronze jaws strip the cap and body portions of the capsules from the pins. Trimming and joining : 10 Trimming and joining The stripped cap and body portions are trimmed to the required length by stationary knives. After trimming to the right length, the cap and body portion are joined and ejected from the machine. SIZE OF CAPSULES : 11 SIZE OF CAPSULES SHAPES OF CAPLUSE : 12 SHAPES OF CAPLUSE *The largest size of the capsule is No: 000.*The smallest size is No: 5.*The standard shape of capsules is traditional, symmetrical bullet shape. FILLING OF HARD GELATIN CAPSULES : 13 FILLING OF HARD GELATIN CAPSULES Various Filling Machine Available… Eli-lily and Co Farmatic Hofliger and Karg Zanasi Parke-Davis. These machine differ in there design and output Slide 14: 14 ZANASI AUTOMATIC CAPSULE FILLING MACHINE HOFLIGER KARG AUTOMATIC CAPSULE FILLING MACHINE Polishing : 15 Polishing Pan Polishing : Acela-cota pan is used to dust and polish. Cloth Dusting : Capsule are rubbed with cloth. Brushing : Capsule are feed under soft rotating brush. Storage Finished capsules normally contain an equilibrium moisture content of 13-16%. To maintain a relative humidity of 40-60% when handling and storing capsules SOFT GELATIN CAPSULE : 16 SOFT GELATIN CAPSULE SOFT GELATIN CAPSULE : 17 SOFT GELATIN CAPSULE Definition:- Soft Gelatin capsules are one piece, hermetically sealed, soft gelatin shells containing a liquid, a suspension, or a semisolid. Soft gelatin is mainly composed of gelatin, plasticizers, preservative, colouring and opacifying agents, flavoring agents and sugars. APPLICATION OF SOFT GELATIN CAPSULE: : APPLICATION OF SOFT GELATIN CAPSULE: The pharmaceutical applications of soft gelatin capsules are: as an oral dosage form as a suppository dosage form as a specialty package in tube form, for human and veterinary use, single dose application for topical, ophthalmic, and rectal ointments. 18 Plasticizer and Gelatin ratio : 19 Plasticizer and Gelatin ratio In soft gelatin capsule the amount of plasticizers used is more In soft gelatin capsule the plasticizer and gelatin ratio is 0.8 : 1 In hard gelatin capsule the plasticizer and gelatin ratio is 0.4 : 1 SHAPE OF CAPSULE : 20 SHAPE OF CAPSULE The shape of soft gelatin capsule are round, oval, oblong, tube. MANUFACTURE OF SOFT GELATIN CAPSULES : 21 MANUFACTURE OF SOFT GELATIN CAPSULES Is manufactured by four methods Plate process Rotary die process Reciprocating die Accogel machine Plate process: : 22 Plate process: Place the gelatin sheet over a die plate containing numerous die pockets, Application of vacuum to draw the sheet in to the die pockets, Fill the pockets with liquid or paste, Place another gelatin sheet over the filled pockets, and Sandwich under a die press where the capsules are formed and cut out. Rotary die process: : 23 Rotary die process: The material to be encapsulated flows by gravity. the gelatin sheets are feed on rolls contain small orifice lined up with the die pocket of the die roll. Two plasticized gelatin ribbons are continuously and simultaneously fed with the liquid or paste fill between the rollers of the rotary die mechanism where the capsule are simultaneously filled, shaped, hermetically sealed and cut from the gelatin ribbon. The sealing of the capsule is achieved by mechanical pressure on the die rolls and the heating(37-40°C) of the ribbons by the wedge. Slide 24: 24 The rotary die process IMPORTANT SPECIFICATIONS OF GELATIN : 25 IMPORTANT SPECIFICATIONS OF GELATIN Bloom or gel strength: It is a measure of cohesive strength of cross-linkage that occurs between molecules and is proportion to the molecular weight of gelatin. Bloom is determined by measuring the weight in grams required to move a plastic plunger of 0.5inches in diameter, 4mm into a 62/3% gelatin that has held at 10°C for 17 hrs. The unit of bloom is grams and it is between 150-250g Slide 26: Viscosity: Is determined on a 62/3% gelatin of water at 60°C and it is a measure of the molecular chain length. Standard used: 25-45 mill poise. Iron content: Iron is always present in raw gelatin, and its concentration usually depends on the iron content of the large quantities of water used in its manufacture . amount should not exceed 15ppm. 26 EVALUVATION OF CAPSULES: : EVALUVATION OF CAPSULES: Weight variation Content uniformity Dissolution test Disintegration test 27 Slide 28: 28 Slide 29: 29 You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.