logging in or signing up MUTAGENS gutta_honey Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 325 Category: Entertainment License: All Rights Reserved Like it (0) Dislike it (0) Added: April 07, 2012 This Presentation is Public Favorites: 1 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript MUTAGENS : MUTAGENS Natalia Stelson Main types of mutagens: Main types of mutagens Chemical - Alkylating agents - Base analogs - Methylating Agents - DNA intercalating agents - DNA crosslinking agents - Reactive oxygen species UV radiation Ionizing radiationAlkylating agents: Alkylating agents Alkyl- groups on DNA Crosslinking G in DNAClassical alkylating agents: Classical alkylating agents Nitrogen mustards Cyclophosphamide Mechlorethamine or mustine (HN2) (trade name Mustardgen ) Uramustine or uracil mustard Melphalan Chlorambucil Ifosfamide Nitrosoureas Carmustine Lomustine Streptozocin Alkyl sulfonates BusulfanAlkylating-like: Alkylating-like Platinum-based chemotherapeutic drugs (termed platinum analogues) act in a similar manner. These agents do not have an alkyl group Platinum Cisplatin Carboplatin Nedaplatin Oxaliplatin Satraplatin Triplatin tetranitrate These agents also bind at N7 of guanine.Nonclassical: Nonclassical Procarbazine ’ Altretamine Some sources explicitly exclude the tetrazines ( dacarbazine , mitozolomide , temozolomide ) Base analogs: Base analogs Similar to one of nucleotides Incorrectly incorporate in DNA Mismatch in base pairing mutation ( change on other pair) - Bromodeoxyuracil ( BrdU ) - 5- Bromouracil (5-BU)Methylating agents: Methylating agents methyl group on DNA Et hylme thanesulfonate (EMS)DNA intercalating agents: DNA intercalating agents is the reversible inclusion of a molecule (or group) between two other molecules (or groups) berberine , ethidium bromide ( fluorescent), proflavine , daunomycin , doxorubicin , thalidomideDNA-crosslinking agents : DNA-crosslinking agents Covalent bound between nucleotides platinum -base medicinesReactive O2 Species: Reactive O 2 Species Hydrogen peroxide Hydroxyl radicals “Stealing” of electronsUV radiation: UV radiation Covalent bound between T ” bulky” T dimersIonizing radiation : Ionizing radiation Ionize molecules by removing electrons You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
MUTAGENS gutta_honey Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 325 Category: Entertainment License: All Rights Reserved Like it (0) Dislike it (0) Added: April 07, 2012 This Presentation is Public Favorites: 1 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript MUTAGENS : MUTAGENS Natalia Stelson Main types of mutagens: Main types of mutagens Chemical - Alkylating agents - Base analogs - Methylating Agents - DNA intercalating agents - DNA crosslinking agents - Reactive oxygen species UV radiation Ionizing radiationAlkylating agents: Alkylating agents Alkyl- groups on DNA Crosslinking G in DNAClassical alkylating agents: Classical alkylating agents Nitrogen mustards Cyclophosphamide Mechlorethamine or mustine (HN2) (trade name Mustardgen ) Uramustine or uracil mustard Melphalan Chlorambucil Ifosfamide Nitrosoureas Carmustine Lomustine Streptozocin Alkyl sulfonates BusulfanAlkylating-like: Alkylating-like Platinum-based chemotherapeutic drugs (termed platinum analogues) act in a similar manner. These agents do not have an alkyl group Platinum Cisplatin Carboplatin Nedaplatin Oxaliplatin Satraplatin Triplatin tetranitrate These agents also bind at N7 of guanine.Nonclassical: Nonclassical Procarbazine ’ Altretamine Some sources explicitly exclude the tetrazines ( dacarbazine , mitozolomide , temozolomide ) Base analogs: Base analogs Similar to one of nucleotides Incorrectly incorporate in DNA Mismatch in base pairing mutation ( change on other pair) - Bromodeoxyuracil ( BrdU ) - 5- Bromouracil (5-BU)Methylating agents: Methylating agents methyl group on DNA Et hylme thanesulfonate (EMS)DNA intercalating agents: DNA intercalating agents is the reversible inclusion of a molecule (or group) between two other molecules (or groups) berberine , ethidium bromide ( fluorescent), proflavine , daunomycin , doxorubicin , thalidomideDNA-crosslinking agents : DNA-crosslinking agents Covalent bound between nucleotides platinum -base medicinesReactive O2 Species: Reactive O 2 Species Hydrogen peroxide Hydroxyl radicals “Stealing” of electronsUV radiation: UV radiation Covalent bound between T ” bulky” T dimersIonizing radiation : Ionizing radiation Ionize molecules by removing electrons