logging in or signing up MUTAGENS gutta_honey Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 325 Category: Entertainment License: All Rights Reserved Like it (0) Dislike it (0) Added: April 07, 2012 This Presentation is Public Favorites: 1 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript MUTAGENS : MUTAGENS Natalia Stelson Main types of mutagens: Main types of mutagens Chemical - Alkylating agents - Base analogs - Methylating Agents - DNA intercalating agents - DNA crosslinking agents - Reactive oxygen species UV radiation Ionizing radiationAlkylating agents: Alkylating agents Alkyl- groups on DNA Crosslinking G in DNAClassical alkylating agents: Classical alkylating agents Nitrogen mustards Cyclophosphamide Mechlorethamine or mustine (HN2) (trade name Mustardgen ) Uramustine or uracil mustard Melphalan Chlorambucil Ifosfamide Nitrosoureas Carmustine Lomustine Streptozocin Alkyl sulfonates BusulfanAlkylating-like: Alkylating-like Platinum-based chemotherapeutic drugs (termed platinum analogues) act in a similar manner. These agents do not have an alkyl group Platinum Cisplatin Carboplatin Nedaplatin Oxaliplatin Satraplatin Triplatin tetranitrate These agents also bind at N7 of guanine.Nonclassical: Nonclassical Procarbazine ’ Altretamine Some sources explicitly exclude the tetrazines ( dacarbazine , mitozolomide , temozolomide ) Base analogs: Base analogs Similar to one of nucleotides Incorrectly incorporate in DNA Mismatch in base pairing mutation ( change on other pair) - Bromodeoxyuracil ( BrdU ) - 5- Bromouracil (5-BU)Methylating agents: Methylating agents methyl group on DNA Et hylme thanesulfonate (EMS)DNA intercalating agents: DNA intercalating agents is the reversible inclusion of a molecule (or group) between two other molecules (or groups) berberine , ethidium bromide ( fluorescent), proflavine , daunomycin , doxorubicin , thalidomideDNA-crosslinking agents : DNA-crosslinking agents Covalent bound between nucleotides platinum -base medicinesReactive O2 Species: Reactive O 2 Species Hydrogen peroxide Hydroxyl radicals “Stealing” of electronsUV radiation: UV radiation Covalent bound between T ” bulky” T dimersIonizing radiation : Ionizing radiation Ionize molecules by removing electrons You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.