RICKETS

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RICKETS : 

RICKETS Govind Jayan

Slide 2: 

vitamin D Endogenous(D3) Exogenous(D2) (cholecalciferol) (ergocalciferol) 7-dehydrocholesterol ergosterol

Functions of vit D : 

Functions of vit D Calcium metabolism: vitamin D enhances ca absorption in the gut & renal tubules Cell differentiation: particularly of collagen & skin epithelium Immunity: important for Cell Mediated Immunity & coordination of the immune response Bone matrix:calcification

Slide 5: 

Raised osteoblastic activity Compensatory parathyroid secretion Reduced Ca and P absorption insufficient vit D Diet sunlight Renal disorder

Slide 7: 

TYPE 1 TYPE 2 Vit D a)Vit D deficiency Intake Absorption Sunlight exposure b)Metabolic disturb. Hepatic Renal Target cell Renal osteodystrophy Reduced Phosphates a)Renal tubule Hypo-phosphataemic rickets Lignac-Fanconi syndrome Renal tubular acidosis b)Reduced intake/absorption of phosphates

CRANIOTABES : 

CRANIOTABES Young infants Ping-pong ball CLINICAL FEATURES

BOSSING OF THE SKULL : 

BOSSING OF THE SKULL Frontal and parietal bones After 6 months

RACHITIC ROSARY : 

RACHITIC ROSARY Costochondral junctions on anterior chest wall

BROADENING OF ENDS OF LONG BONES : 

BROADENING OF ENDS OF LONG BONES 6-9 months Wrists & knees

Slide 12: 

Wide ankles

HARRISON’S SULCUS AND POTBELLY : 

HARRISON’S SULCUS AND POTBELLY Horizontal depression-diaphragm insertion Muscular hypotonia

DEFORMITIES OF LONG BONES : 

DEFORMITIES OF LONG BONES Starts walking BOW-LEGS

Slide 15: 

KNOCK-KNEES

Slide 16: 

WINDSWEPT DEFORMITY

THANK YOU : 

THANK YOU

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