Magnetic target drug delievery system

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Review on Magnetic target drug delivery system:

Review on Magnetic target drug delivery system Presented by: M.HYNDAVI I M.Pharmacy (Pharmaceutics) 10M71S0305 Under the guidance of Mr. A.V BADRINATH M.Pharm.(Ph.D.) Department of Pharmaceutics Beloved Principal C.MADHU SUDHANA CHETTY M.Pharm., Ph.D., MBA ANNAMACHARYA COLLEGE OF PHARMACY

Contents:

Contents Drug Targeting Approaches For Drug Targeting Principles Of Magnetic Targeting Magnetic Particles Types of Magnetic Carriers Functionalization Of Magnetic Carriers Release Of The Drug From Magnetic Carriers Advantages Applications Limitations Conclusion References

Drug Targeting:

Drug Targeting The activity of the most drugs suffers from inability to accumulate at the site of action Drug targeting is the delivery of the drugs to receptors or organs or any specific part of the body to which one wishes to deliver exclusively.

Approaches For Drug Targeting:

Approaches For Drug Targeting Physical approach-formulating drug using a particulate drug device(magnet).Releases the drug by virtue of its physical localization Biological Approach-delivery of drug using a carrier system like antibodies, lecithin. Chemical Approach-incorporating chemical delivery systems where drug release based on enzymatic activation

Principles Of Magnetic Targeting:

Principles Of Magnetic Targeting In this technique, drug is bound to a magnetic compound , injected into a patient’s blood stream, and stopped with a powerful magnetic field in the target area. Depending upon the type of drug , it is then slowly released from the magnetic carriers. Very high concentrations of drugs can be achieved near the target site ,without any toxic effects to surrounding tissue or to the whole body

Comparing Systemic Drug Delivery with Magnetic targeting:

Comparing Systemic Drug Delivery with Magnetic targeting

Magnetic Particles:

Magnetic Particles Magnetic carriers receive their magnetic responsiveness to a magnetic field from incorporated materials such as magnetite, maghemite, iron, nickel, cobalt, neodymium– iron–boron or samarium–cobalt. For biomedical applications, magnetic carriers must be water-based, biocompatible, non-toxic, and non- immunogenic. Magnetic carriers are normally grouped according to size. magnetic particles in the range of 10–500 nm are usually called magnetic nanospheres and any particles of just below 1–100 micro meters are magnetic microspheres.

Types Of Magnetic carriers:

Types Of Magnetic carriers Magnetic microspheres Magnetic liposomes Magnetic nanoparticles Magnetic resealed erythrocytes Magnetic emulsions

Functionalization Of Magnetic Carriers:

Functionalization Of Magnetic Carriers The surface of the magnetic carriers can be modified by various coating materials. Without the coating , they have hydrophobic surfaces with large surface to volume ratios and a propensity to agglomerate. A proper surface coating allows them to be dispersed uniformly into ferrofluids and also the stability is improved.

Release Of The Drug From Magnetic Carriers:

Release Of The Drug From Magnetic Carriers Diffusion-occurs when drug molecules dissolve in bodily fluids around or within the particles and migrate away from the particles. Degradation- takes place when the polymer chains hydrolyze into lower molecular weight species, releasing drug molecules that are trapped by the polymer chains. Swelling-When placed in the body, they swell to increase inside pressure and porosity, enabling the drug molecules to diffuse from the swollen network.

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Time = 0 Diffusion Degradation Swelling

Advantages:

Advantages The magnetic particles are well tolerated by the body, magnetic fields are harm less to biological systems and adaptable to any part of the body. It is possible to replace large amounts of freely circulating drug with much lower amounts of drug targeted magnetically to localized disease sites, reaching effective and up to several fold increased localized drug levels. Magnetic carriers overcome two major problems encountered in drug targeting reticuloendothelial system(RES) clearance and target site specificity

Applications :

Applications Magnetic target drug delivery system has many applications in various fields. Magnetic delivery of chemotherapeutic agents to treat tumors Magnetic targeting of radioactivity Treatment of tumors with magnetically induced hyperthermia Magnetic systems for diagnosis of disease Magnetic control of pharmacokinetic parameters and drug release. Magnetic resonance imaging(MRI) Magnetic Transfections Tissue engineering Iron detection and chelation therapy Magnetic systems for cell separation

Limitations :

Limitations The main limitation in magnetic drug delivery is the inability to focus treatment to target deep inside the body .When stationary magnets are used ,they can only concentrate near the skin surface. And also, it lacks methodology for designing the magnetic field strength and gradient, so it is necessary to generate the strong magnet by a few centimeters for medical applications

Conclusion:

Conclusion In spite of certain drawbacks, still play an important role in the selective targeting, and the controlled delivery of various drugs. It is a challenging area for future research in the drug targeting so more researches, long term toxicity study, and characterization will ensure the improvement of magnetic drug delivery system. The future holds lot of promises in magnetic micro carriers and by further study this will be developed as novel and efficient approach for  targeted drug delivery system.

References:

References Lancava G M. et al ,J Magn Mater, 1999,201,434 Ahmad, A., Evans, H.M., Ewert, K., George, C.X., Samuel, C.E., Safinya, C.R., 2005. New multivalent cationic lipids reveal bell curve for transfection efficiency versus membrane charge density: lipid–DNA complexes for gene delivery. J. Gene Med. 7, 739–748. Shinoda, Kozo and Stig Friberg. Emulsions and Solubility. New York: Wiley and Sons, 1986. Alexiou, C., Arnold, W., Klein, R.J., Parak, F.G., Hulin, P., Bergemann, C., Erhardt, W., Wagenpfeil, S., Lübbe, A.S., 2000. Locoregional cancer treatment with magnetic drug targeting. Cancer Res. 60, 6641–6648 Linda A. Harris. “Polymer Stabilized Magnetite Nanoparticles and Poly(propylene oxide) Modified Styrene Dimethacrylate Networks.” Dissertation Submitted Virginia Polytechnic Institute and State University, April 19, 2002. Tech Notes. Bang Labs, Inc. http://www.bangslabs.com/support/index.php

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Thank you