Mucoadhesive buccal drug delivery system (TABLET)

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Mucoadhesive buccal drug delivery system:

Mucoadhesive buccal drug delivery system Presented by, Ganesh S. Lokhande Guided by, Dr. S. D. Barhate Department of Pharmaceutics Smt. S. S. Patil College of Pharmacy, Chopda, Jalgaon. 1

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Introduction: Definition of mucoadhesion Need Various drug delivery systems Dosage forms Mucoadhesive buccal drug delivery system 2

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Advantages: Termination of therapy is easy. Bypasses the first pass metabolism- greater bioavailability. Buccal mucosa is highly perfused with blood vessels- greater permeability. Permits localization of drug to the oral cavity for a prolonged period of time. Limitations: Drugs, which are unstable at buccal pH, cannot be administered by this route. Drugs, which irritate the oral mucosa, have a bitter or unpleasant taste, cannot be administered by this route. 3

Mucoadhesive polymers: to penetrate or adhere the mucus network or tissue crevices.:

Mucoadhesive polymers: to penetrate or adhere the mucus network or tissue crevices. Poly vinyl pyrrolidone Methyl cellulose Hydroxy propyl cellulose Other cellulose derivative Anionic group- e.g. Carbopol, Polyacrylates Cationic group- Chitosan Neutral group-Eudragit Hydrophilic Hydrogels 4

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Mucoadhesive mechanisms: Electronic theory transfer of electrons Adsorption theory devices adheres to the mucus by secondary chemical interaction such as in van der waals and hydrogen bonds, electrostatic attraction. Penetration enhancers: e.g. Bile salts and other steroidal detergents Fatty acids Salicylates, Chelating agents, Sulfoxides (DMSO) Changing mucus rheology Increasing fluidity of lipid bilayer membrane Overcoming the enzymatic barrier Increasing the thermodynamic activity of drugs 5

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Wetting theory affinity to surface in order to spread over it. contact angle 6

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Diffusion theory: interaction of both polymer & mucin chains to sufficient depth to create a semi-permanent adhesive bond. penetration rate 7

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Fracture theory: most used theory it concerned only with the force required to separate a parts. it is appropriately used for rigid & semi rigid bioadhesive materials in which the polymer chains do not penetrate into mucus layer 8

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In vivo mucoadhesive behavior of optimized formulation 9

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Evaluation parameters of buccal tablet: Thickness Hardness (kg/cm2) Disintegration Test Avg. weight Content (%) Mucoadhesive Strength (gm) Swelling index. (%) Stability of Buccal Tablets Surface pH Study In Vitro Drug Release Studies Ex Vivo Mucoadhesion Time In Vivo Mucoadhesive Performance 10

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References: Gandhi SD et al ; Mucoadhesive drug delivery systems-an unusual maneuver for site specific drug delivery system; Pharma science monitor an international journal of pharmaceutical sciences(2011) Hirlekar RS; Design of buccal drug delivery system for a poorly soluble drug; Asian journal of pharmaceutical and clinical research; Vol.2 issue 3, July-September 2009 Bhanja S, Ellaiah P, Martha SK et al; Formulation and in vitro evaluation of mucoadhesive buccal tablets of Timolol maleate ; International journal of pharmaceutical and biomedical research 2010, 1 (4), 129-134 Punitha S et al; Polymers in mucoadhesive buccal drug delivery system – A review; Int. J. Res. Pharm. Sci. Vol-1, Issue-2, 170-186, 2010 Shanker G, Kumar CK et al; Formulation and Evaluation of Bioadhesive Buccal Drug Delivery of Tizanidine Hydrochloride Tablets; American Association of Pharmaceutical Scientists PharmSciTech , Vol. 10, No. 2, June 2009 11

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